Sun, Jul 23, 2017 | updated 02:22 AM IST

Now, a triple-therapy patch to keep colon cancer at bay

Updated: Aug 01, 2016 15:14 IST      
Now, a triple-therapy patch to keep colon cancer at bay

Washington D.C, Aug 1 (ANI): A newly-developed triple-therapy patch may soon make open surgeries a history for colon cancer patients.

Investigators at Brigham and Women's Hospital developed a hydrogel patch that can adhere to tumours in a preclinical model of colon cancer, delivering a local, combination treatment as the elastic gel breaks down over time.

The new technique may allow clinicians to one day use diagnostic colonoscopy equipment to immediately deliver treatment without the need for open surgery at a later date.

The researchers were able to deliver three therapeutic strategies in their mouse model of colon cancer: gene therapy, chemotherapy or thermal ablation or a combination of all three.

The team used gold nanoparticles to deliver a gene therapy treatment that targets Kras, a known cancer gene, and used near-infrared radiation to release a chemotherapeutic and cause heat damage to the cancer cells.

The local, triple-combination therapy not only shrank tumours but also had sustained effect overtime, preventing tumour recurrence and significantly extending survival of mice.

Senior author Natalie Artzi said, "Our preclinical results are remarkable - by using local, combination treatment, we achieved complete tumor remission when the patch was applied to non-resected tumours and elimination of tumor recurrence when applied following tumor resection.

She added, "Next, we would like to use colonoscopy equipment to locally apply the patch to tumors in large preclinical models. Using minimally invasive techniques to apply the triple-therapy patch and evaluate its efficacy has the potential to improve clinical procedures and therapeutic outcomes."

The findings are published in the journal Nature Materials. (ANI)

This is your brain on depression

Updated: Jul 22, 2017 13:55 IST     

Washington D.C. [USA], July 22 (ANI): Got the blues? According to a recent study, depression can change the structure of your brain.

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Rush-hour pollution may be more harmful than thought

Updated: Jul 22, 2017 10:57 IST     

Washington D.C. [USA], Jul 22 (ANI): Turns out, rush-hour commuters may be in for a double whammy of pollution exposure.

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TRAC, MedGenome announce Cancer Immunotherapy solution

Updated: Jul 22, 2017 06:24 IST     

New Delhi [India], July 22 (ANI): Toronto Recombinant Antibody Centre (TRAC) from the University of Toronto, Canada agreed to license MedGenome's patented cancer immunotherapy solution OncoPept to develop biomarkers for their drug candidates against immune modulators to treat cancer.

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Are some people genetically programmed to be depressed?

Updated: Jul 21, 2017 09:48 IST     

Washington D.C. [USA], Jul 21 (ANI): It's a sombre thought, but it seems that some of us are born more likely to be depressed.

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Washington D.C. [USA], Jul 21 (ANI): A team of researchers has come up with a new imaging technique that can diagnose cardiac sarcoidosis much more accurately than traditional tests.

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Ahmedabad (Gujarat) [India], July 21 (ANI): Ayurveda is a form of alternative medicine which seeks to treat and integrate body, mind and spirit using a comprehensive holistic approach especially by emphasizing diet, herbal remedies, exercise, meditation, breathing, and physical therapy.

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Washington D.C. [USA], Jul 20 (ANI): When it comes to faring well after chemotherapy, a cancer patient's social interaction matters, according to a recent study.

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New radiotherapy find offers hope to cancer patients

Updated: Jul 20, 2017 10:06 IST     

Washington D.C. [USA], Jul 20 (ANI): An exciting discovery in the cancer treatment is having dramatic results.

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New strategy could yield more effective flu shots

Updated: Jul 20, 2017 09:46 IST     

Washington D.C. [USA], Jul 20 (ANI): A boosting skin vaccination with a biodegradable microneedle patch and protein constructed from sequences of influenza virus subtypes could improve the effectiveness of conventional influenza vaccines, according to a recent study.

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Revealed! Best time to sleep to wake up feeling refreshed

Updated: Jul 20, 2017 04:09 IST     

London [UK], July 20 (ANI): The secret of a good night's sleep has finally been unveiled!

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Anxiety drug may help you with fear of social rejection

Updated: Jul 19, 2017 14:22 IST     

Washington D.C. [USA], July 19 (ANI): A team of researchers has found that low doses of anxiety disorder-reducing drug can help highly-anxious people overcome their fear of being over-looked and rejected socially.

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Washington D.C. [USA], July 19 (ANI): Good news! A new technology may help to non-invasively predict children or newborn at risk of an asthma attack.

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Your poor sleep may increase risk of Alzheimer's: Study

Updated: Jul 19, 2017 10:08 IST     

Washington D.C. [USA], July 19 (ANI): Beware! Breathing problems during sleep may be a signal of an increased risk for Alzheimer's disease, warns a study.

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Indian population, carrier of hepatitis B: Study

Updated: Jul 18, 2017 20:01 IST     

New Delhi [India], July 18 (ANI): Viral hepatitis is inflammation and damage of the liver by viruses , most commonly hepatotrophic (predominantly with an affinity for attacking the liver - Hepatitis A , B , C , D , E ) or non hepatotrophic viruses (Generalized involvement of human body with liver as a target tissue seen with Dengue virus , Chikungunya etc.).

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This monsoon, let's be HepAware!

Updated: Jul 18, 2017 18:01 IST     

New Delhi [India], July 18 (ANI): Hepatitis A is mild to the moderate viral disorder of the liver which is affected by the consumption of contaminated food and water. Unfortunately, monsoons are the best time when air/water borne infections are at its peak.

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Washington D.C. [USA], July 18 (ANI): If your grandparents are suffering from dementia, then you can help them by interacting with them about their interests for an hour a week and improve their quality life.

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New Delhi [India], July 17 (ANI): Commemorating its 21st Founder's Day and in an endeavor to promote healthy lifestyle, Pushpawati Singhania Hospital & Research Institute (PSRI) a multi-specialty hospital here organized free health check-up camps and school wellness programme.

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Here's how weekly social hour can help dementia patients

Updated: Jul 17, 2017 11:49 IST     

Washington D.C. [USA], Jul 17 (ANI): Person-centred activities combined with just one hour a week of social interaction can improve quality of life and reduce agitation for people with dementia living in care homes, while saving money, according to a recent study.

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Combo therapy better than drug alone against Alzheimer's

Updated: Jul 17, 2017 11:34 IST     

Washington D.C. [USA], Jul 17 (ANI): Combining a specific care management program with a commonly-prescribed drug for Alzheimer's disease is better at turning back the clock on the ageing brain than medication alone, according to a recent study.

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Washington D.C. [USA], Jul 17 (ANI): Nearly 30 percent of stroke patients are refusing to take life-saving statins because they are worried about the side effects, according to a recent study.

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