Fri, Mar 24, 2017 | updated 09:30 PM IST

Erectile dysfunction drugs don't cut prostate cancer risk

Updated: Aug 02, 2016 11:42 IST

Washington D.C, Aug 2 (ANI): Turns out, popping erectile dysfunction (ED) drugs cannot ward off your risk of prostate cancer.

ED is a common problem with a prevalence of 20 percent to 40 percent in the sixth decade of life and approaching 75 percent in the seventh decade. Drugs such as tadalafil, sildenafil and vardenafil are phosphodiesterase type 5 inhibitors (PDE-5is) commonly used to treat ED. Since PDE-5is were first introduced in 1998, their durability, safety, and efficacy for treating ED have been clearly demonstrated.

"In vitro mouse studies have suggested that these drugs might have some anticancer activity, but the evidence in human subjects is mixed," said lead investigator Stephen J. Freedland of the Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai in Los Angeles, CA.

He added, "Given the routine use of PDE-5i and the possibility that these agents may have anticancer activity, we wanted to test the association between their use and risk of developing prostate cancer."

Using data from REDUCE, a four-year, multicenter study testing the effect of daily dutasteride to treat benign prostatic hyperplasia on prostate cancer risk in men, the authors analysed whether ED drug use by more than 6,500 patients may have affected overall prostate cancer risk and disease grade.

Of the 6,501 men in the study 364 used PDE-5i at baseline. During the study, prostate cancer was diagnosed in 71 of these men compared to 1,391 of 6,137 men who did not take PDE-5i, which was not significantly different. An analysis of prostate cancer grade also showed no correlation between PDE-5i use and low or high grade cancer. Because PDE-5i use was significantly higher among North American men, the authors looked for a regional effect. They found some correlation between ED use and lower prostate cancer diagnosis in North American men, but this did not reach statistical significance.

"Future studies with longer followup and larger study populations are warranted to determine the association between PDE-5i and prostate cancer," said first author Juzar Jamnagerwalla.

The study is published in The Journal of Urology. (ANI)

New Delhi [India], Mar. 24 (ANI): Continuing its efforts to raise awareness on tuberculosis and its diagnosis, Division of Clinical Microbiology & Molecular Medicine Department of Laboratory Medicine, AIIMS, and BD (Becton Dickinson India) for the third consecutive year organized a symposium today on "challenges in diagnosis and eradication of tuberculosis".

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Updated: Mar 22, 2017 09:30 IST

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Updated: Mar 22, 2017 09:20 IST

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Washington D.C. [USA], Mar. 22 (ANI): Despite existing prevention methods, transmission of infections with HIV, hepatitis B, syphilis or rubella from mother to child before and during birth as well as in infancy still occur across Europe.

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Changes in blood may spur Alzheimer's disease

Updated: Mar 22, 2017 07:29 IST

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Spraying onto broken hearts to heal them

Updated: Mar 22, 2017 06:45 IST

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Updated: Mar 21, 2017 07:50 IST

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