Tue, Feb 21, 2017 | updated 01:41 PM IST

Being skinny in mid-life can up your Alzheimer's risk

Updated: Aug 03, 2016 12:36 IST

Washington D.C, Aug 3 (ANI): Turns out, being skinny may not be all it's cracked up to be as a recent study has found a link between a lower weight and early Alzheimer's disease.

Researchers at Brigham and Women's Hospital (BWH) and Massachusetts General Hospital (MGH) found an association between lower weight and more extensive deposits of the Alzheimer's-associated protein beta-amyloid in the brains of cognitively normal older individuals.

The association was seen in particular among individuals carrying the APOE4 gene variant, which is known to increase the risk of Alzheimer's.

"Elevated cortical amyloid is believed to be the first stage of the preclinical form of Alzheimer's disease, so our findings suggest that individuals who are underweight late in life may be at greater risk for this disease," said senior author Gad Marshall.

He added, "Finding this association with a strong marker of Alzheimer's disease risk reinforces the idea that being underweight as you get older may not be a good thing when it comes to your brain health."

While the concept of a preclinical version of Alzheimer's disease is theoretical and not yet being used to guide clinical diagnosis or treatment, the current hypothesis involves three stages. Individuals at stage 1 are cognitively normal but have elevated amyloid deposits; stage 2 adds evidence of neurodegeneration, such as elevated tau deposits or characteristic loss of certain brain tissues, with no cognitive symptoms; and stage 3 adds cognitive changes that, while still in a normal range, indicate a decline for that individual.

This investigation explored the relationship between body mass index (BMI) and beta amyloid levels in the brains of the first 280 participants to enroll in HABS, who were ages 62 to 90, cognitively normal and in good general health.

Researchers hope that future studies will explain the mechanism behind the association between lower BMI and increased amyloid levels.

Marshall concluded, "One way to get closer to determining any cause and effect relationship will be following these individuals over time to see whether their baseline BMI does predict the development of symptoms, which we are doing in HABS and eventually investigating whether maintaining or even increasing BMI in late life has an effect on outcomes. Right now, we're also studying whether BMI is associated with any other clinical and imaging markers of Alzheimer's disease."

The study is reported in the Journal of Alzheimer's Disease. (ANI)

Chronic knee pain may be treated online

Updated: Feb 21, 2017 06:41 IST

Washington D.C. [USA], Feb. 21 (ANI): A study has found out that an online intervention, combining home exercise and pain-coping skills training, provided substantial clinical benefits for patients suffering from chronic knee pain.

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Washington D.C. [USA], Feb. 21 (ANI): Only exercise is not enough to maintain that figure, which is an after effect of much toil and sweat!

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New Delhi [India], Feb. 20 (ANI): With rising life expectancy, increasingly sedentary lifestyles and surge in incidence of obesity, India is also witnessing a resultant rise in orthopedic problems as a natural corollary.

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Children inherit obesity from parents: Study

Updated: Feb 20, 2017 14:54 IST

Washington D.C. (USA), Feb. 20 (ANI): A study reveals that 35-40 percent of a child's 'Body Mass Index' - how fat or thin they are - is inherited from their parents.

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New Delhi [India], Feb 20. (ANI): Good news for all those lazy-headed not-really-a-cleanliness-freak out there! Scientists have found out that the obsession with hygiene could even be turning some beneficial bacteria found in the human gut into "endangered species".

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New Delhi [India], Feb 20. (ANI): In order to persuade someone to quit smoking, it is the 'emotions' that need to be triggered rather than inciting fear in an individual.

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No difference between good or bad diet: Study

Updated: Feb 20, 2017 05:54 IST

New Delhi [India], Feb 20. (ANI): Ever faced a choice between Brown and white bread?

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Washington D.C. [USA], Feb. 19 (ANI): To boost sustainability of livestock production, a study finds that gene editing - one of the newest and most promising tools of biotechnology - enables animal breeders to make beneficial genetic changes, without bringing along unwanted genetic changes.

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People with ADHD may have smaller brain volume

Updated: Feb 19, 2017 07:09 IST

New Delhi [India], Feb 19. (ANI): In a latest study it has been found out that people diagnosed with attention deficit hyperactivity disorder (ADHD) have smaller brain volume than those without the disorder.

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New Delhi [India], Feb 19. (ANI): What if we tell you that scientists can actually slow down the process of ageing. Sounds too good to be true right?

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New Delhi [India], Feb 19. (ANI): Lefty or righty? Well it was decided when you were still in your mum's womb!

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Dads-to be face greater risk of depression

Updated: Feb 19, 2017 06:53 IST

New Delhi [India], Feb 19. (ANI): Expecting a baby is always a joyous experience for both the mother and the father, however a latest study has found out that fathers-to-be can be at risk of depression symptoms if they feel stressed or are in poor health.

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New Delhi [India], Feb 19. (ANI): Do you find it difficult hearing out people at a noisy bar or a restaurant even though you have passed the hearing test with flying colors? Well, you might be secretly deaf!

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New Delhi [India], Feb 19. (ANI): What if we told you that rice has the potential of carrying arsenic and is more than hazardous to feed it to infants!

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Washington D.C. [USA], Feb. 18 (ANI): Now you can save your kid from surgery, as a study shows that antibiotics may be an effective treatment for acute non-complicated appendicitis in children, instead of surgery.

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Washington D.C. [USA], Feb. 18 (ANI): Attention new mommies, sing lullabies to your new born to feel more connected to your babies, suggests a study.

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Washington D.C. [USA], Feb. 18 (ANI): Cancer patients can improve their quality of life with just 30 minutes of walking, suggests a study.

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New Delhi [India], Feb. 17 (ANI): Birth of a baby may be a sweet moment but changing life style of women is posing 'sweet' challenge to it.

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New Delhi [India], Feb. 17 (ANI): Good news! A recent study shows that antibiotics may be an effective treatment for acute non-complicated appendicitis in children, instead of surgery.

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'Seagrass' can improve marine water quality

Updated: Feb 17, 2017 07:07 IST

Washington D.C. [USA], Feb. 17 (ANI): Underwater flowering plants and seagrass meadows known to produce natural antibiotics, can also improve the water quality of sea by suppressing pollution, reveals a study.

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