Tue, May 30, 2017 | updated 12:59 PM IST

New lung cancer find paves way for better therapies

Updated: Aug 04, 2016 12:47 IST      
New lung cancer find paves way for better therapies

Washington D.C, Aug 4 (ANI): A team of researchers has successfully inhibited tumour growth in a new subtype of lung cancer.

Adenocarcinomas, a non-small cell lung cancer (NSCLC), account for about 40 percent of cancer diagnoses, but few treatments are available for the disease.

The team led by Elena Levantini of Beth Israel Deaconess Medical Center (BIDMC) identified a subtype of human adenocarcinoma. The research could help determine which individuals are at greatest risk of developing lung tumors that may be amenable to a new therapy to inhibit their progression.

"Advances in lung cancer therapy require a greater understanding of the molecular origins of this deadly disease," said last corresponding author Levantini. "Understanding the differences among lung cancers also could lead to innovations in treatment strategies and allow us to overcome drug-resistance, relapse and disease progression."

Levantini and colleagues previously showed that NSCLC tumor cells frequently express too little or none of a transcription factor called C/EBP alpha, a protein that regulates gene expression and cell proliferation in lung tissues. It's also known to play a role in a form of leukemia, as well as liver cancer, squamous cell skin carcinomas, squamous cell cancers of the head and neck and other cancers.

In a series of in vitro experiments, the researchers demonstrated that C/EBP alpha indeed works as a tumour suppressant by restraining the expression of another molecule known to play a role in triggering and maintaining tumor growth. This molecule, called BMI1, is an oncogenic protein that has been implicated in colon cancer, a form of leukemia and breast and gastric cancers.

"Our findings suggest that the lung cancer subtype defined by the loss of C/EBP alpha expression might specifically benefit from therapies that inhibit BMI1," the scientists wrote. "Thus, identifying factors that modulate its expression has generated major clinical interest."

The research team was also able to validate its findings in mice.

Levantini noted, "Our findings could help us design better therapies for the subset of adenocarcinoma patients with low C/EBP alpha and high BMI1 expression pattern."

The results are published in the journal Science Translational Medicine. (ANI)

Washington D.C. [USA], May 29 (ANI): A new therapeutic approach may save diabetics from amputation by promoting wound healing, a recent study has suggested.

Full Story >>

Washington D.C. [USA], May 29 (ANI): According to a recent study, an injectable antibody can be really helpful for lowering blood lipids and thereby potentially preventing coronary artery disease and other conditions caused by the build-up of fats, cholesterol.

Full Story >>

Gene discovery offers hope for female incontinence cure

Updated: May 29, 2017 09:52 IST     

Washington D.C. [USA], May 29 (ANI): A team of scientists has made a breakthrough in the treatment of female incontinence - the urge to urinate frequently - by identifying genes that trigger the condition.

Full Story >>

This protein can help ward off chronic heart failure

Updated: May 29, 2017 09:33 IST     

Washington D.C. [USA], May 27 (ANI): Japanese researchers have identified a receptor protein on the surface of heart cells that promotes chronic heart failure, affecting more than 20 million people worldwide.

Full Story >>

New dog skull find may help detect birth defects

Updated: May 29, 2017 09:33 IST     

Washington D.C. [USA], May 28 (ANI): A study of dog DNA has linked a genetic mutation to flat face shapes such as those seen in pugs and bulldogs.

Full Story >>

Soon, an accurate, cheap genetic test for anal cancer

Updated: May 28, 2017 13:56 IST     

Washington D.C. [USA], May 28 (ANI): A new genetic test could be an accurate and inexpensive way to find and treat those at highest risk of anal cancer - a disease with growing incidence in women, men who have sex with men (MSM) and people with HIV.

Full Story >>

Fight against leprosy: Efforts honoured with ICN award

Updated: May 28, 2017 13:44 IST     

New Delhi [India], May 28 (ANI): The International Council of Nurses (ICN) presented its Health and Human Rights Award to Yohei Sasakawa, Chairman of the Nippon Foundation, at the 2017 ICN Congress in Barcelona, Spain, on May 27.

Full Story >>

Higher BMI can cause cardiovascular problems for youngsters

Updated: May 28, 2017 08:56 IST     

Washington D.C. [USA], May 28 (ANI): A recent study shows that higher than normal Body Mass Index (BMI) may cause worse cardiovascular health in those aged as young as 17.

Full Story >>

Probiotics helpful in treating depression: Study

Updated: May 28, 2017 08:36 IST     

Washington D.C. [USA], May 28 (ANI): According to a new study, adults with irritable bowel syndrome (IBS) reported improvements from co-existing depression, when they took a specific pro-biotic than adults with IBS who took a placebo.

Full Story >>

Exposure to diesel pollution ups risk of heart attack

Updated: May 28, 2017 07:10 IST     

Washington D.C. [USA], May 28 (ANI): A word of caution; avoid places with heavy traffic or try to find a different route as a study has warned that exposure to diesel pollution causes heart attack, heart failure and death.

Full Story >>

Statins improves heart structure and function: Study

Updated: May 27, 2017 23:02 IST     

Washington D.C. [USA], May 27 (ANI): Briton researchers have found that group of drugs, which act to reduce levels of cholesterol in the blood, is linked to improved heart structure and its function.

Full Story >>

Rock climbing for three hours a week may treat depression

Updated: May 27, 2017 19:14 IST     

Washington D.C. [USA], May 27 (ANI): A team of researchers have revealed that bouldering, a form of rock climbing performed without the use of ropes or harnesses, for three hours a week may help to treat depression.

Full Story >>

Beware! Recreational cannabis doubles the risk of gum disease

Updated: May 27, 2017 16:56 IST     

Washington D.C. [USA], May 27 (ANI): Beware! A study has warned that frequent recreational use of cannabis, including marijuana, hashish, and hash oil, doubles the risk of gum disease.

Full Story >>

Bengaluru (Karnataka) [India], May 27 (ANI): BGS Gleneagles Global Hospitals, a Parkway Pantai enterprise, successfully pioneered the day care Bone Marrow Transplant (BMT) transplant program for low risk transplants like autologous transplant for multiple myeloma and mini-allo transplant for various hematological disorders.

Full Story >>

New hope for stroke patients with disabilities

Updated: May 27, 2017 11:22 IST     

Washington D.C.[USA], May 27 (ANI): Stroke patients left with disabilities have been offered new hope as scientists have developed mind-controlled device that helps them retrain brains to move paralyzed hands.

Full Story >>

Washington D.C. [USA], May 27 (ANI): According to a new study, people suffering from HIV tend to spend more time in therapy to manage the chronic condition.

Full Story >>

New Delhi [India], May 26 (ANI): Latest robotic surgery may work as a boon for patients suffering from early stage oropharyngeal carcinoma (cancer of the mouth, neck and throat).

Full Story >>

23-year-old suffers severe heart attack due to smoking

Updated: May 26, 2017 16:01 IST     

New Delhi [India], May 26 (ANI): With several reasons attributing to a paradigm shift in the age groups suffering from heart attacks to younger age brackets, tobacco induced cardiac arrests rate as one of the topmost ones.

Full Story >>

New Delhi [India], May 26 (ANI): According to statistics, India has the third largest Muslim population in the world. The month of Ramadan is about to begin and a vast majority of this population will be fasting for a large number of days.

Full Story >>

Frequent recreational weed puts your mouth at risk

Updated: May 26, 2017 08:12 IST     

Washington D.C. [USA], May 26 (ANI): Frequent recreational use of cannabis, including marijuana, hashish, and hash oil, ups the risk of gum disease, a recent study has found.

Full Story >>