Mon, Apr 24, 2017 | updated 10:45 PM IST

'Born to be benign' cells could help in identifying oesophageal cancer at early stage

Updated: Aug 20, 2016 16:02 IST      
'Born to be benign' cells could help in identifying oesophageal cancer at early stage

Washington D.C, Aug. 20 (ANI):A recent study has revealed some cells that are 'born to be bad' could be identified early, preventing the need for repeated endoscopies.

Barrett's Oesophagus, a common condition that affects an estimated 1.5 million people in the UK alone involves normal cells in the oesophagus (food pipe) being replaced by an unusual cell type called Barrett's Oesophagus, and is thought to be a consequence of chronic reflux (heartburn).

People with Barrett's have an increased risk of developing oesophageal cancer. Although the overall lifetime risk of developing oesophageal cancer in people with Barrett's is significant, most Barrett's patients do not develop cancer in their lifetime.

While currently there is no easy way to distinguish between high and low-risk Barrett's patients, regular surveillance by endoscopy is the best way to prevent cancer and know about it.

A test based on the genetic make-up of the Barrett's lesions could benefit patients through improved diagnosis, giving people at high risk of cancer the best care, and reducing the burden of endoscopy for those at low risk.

Trevor Graham from QMUL's Barts Cancer Institute said, "We have shown that some Barrett's oesophagus lesions are 'born to be bad' - and conversely that some are 'born to be benign'. Once these results are validated in other patients and over longer periods of time, we will be able to say with confidence which people with the benign form can be spared unnecessary endoscopy and worry.

This will dramatically improve the quality of life for people with Barrett's, and provide substantial cost saving to healthcare providers."

The team followed up more than 300 Barrett's patients over three years, and analysed around 50,000 cells in the process. They performed genetic analysis of individual cells and measured the genetic diversity in each lesion to track it over time.

The results validated a previous group's discovery that measurement of the genetic diversity between Barrett's cells in any given lesion is a good predictor of which patients are at high risk of developing cancer.

In addition to it, the team found that there were no significant changes in genetic diversity during the three years that the patients were followed. This suggests that the genetic diversity amongst a person's Barrett's cells is essentially fixed over time, and mutations have little impact on the lesion's development.

Whenever someone's Barrett's is tested, their future risk can be predicted regardless of how soon it is after the appearance of abnormal cells.

Graham commented, "Our findings are important because they imply that a person's risk of developing oesophageal cancer is fixed over time. In other words, we can predict from the outset which Barrett's patients fall into a high risk group of developing cancer - and that risk does not change thereafter."

The study is published in Nature Communications. (ANI)

Gene reveals cause of fatal childhood disorder: Study

Updated: Apr 24, 2017 17:51 IST     

New Delhi [India], Apr 24 (ANI): A gene, involved in brain development, which can lead to severe disability and infant death, has been identified by scientists.

Full Story >>

Alcohol: the modern age liver killer

Updated: Apr 24, 2017 17:51 IST     

New Delhi [India], Apr 24 (ANI): Alcohol is predominantly metabolized through liver, hence its cumulative toxicity over years play important role in liver diseases or pancreatic diseases.

Full Story >>

Washington D.C. [USA], April 24 (ANI): Due to increasing deaths because of prostate cancer among men, US researchers have suggested a special screening more frequently and at an early age to avoid the development of preclinical prostate cancer - that is not symptomatic - to advanced stages.

Full Story >>

Love guzzling diet sodas? Here is why you should NOT

Updated: Apr 24, 2017 07:02 IST     

New York [U.S.], Apr. 24 (ANI): Still downing gallons of diet soda despite knowing that it wrecks your body? Maybe the knowledge of artificially sweetened beverages taking a toll on your brain as well ought to make an impact on your unhealthy habit.

Full Story >>

Washington D.C. [USA], Apr 23 (ANI): A recent study has demonstrated that in the general population, central obesity, insulin resistance, diabetes, lipid abnormalities and high alcohol consumption were the strongest predictors of severe liver disease.

Full Story >>

Breastmilk may help detect your cancer risk

Updated: Apr 23, 2017 11:50 IST     

Washington D.C. [USA], Apr 23 (ANI): Breastmilk might offer clues about a woman's cancer risk, according to a recent research.

Full Story >>

Soon, new weapon in war against obesity

Updated: Apr 23, 2017 11:14 IST     

Washington D.C. [USA], Apr 23 (ANI): A team of scientists has uncovered a potential approach to combat obesity.

Full Story >>

Turns out, being obese is worse than smoking

Updated: Apr 23, 2017 10:52 IST     

Washington D.C. [USA], Apr 23 (ANI): You may want to shed those extra kilos as a recent study has found obesity as a top cause of preventable life-years lost.

Full Story >>

Washington D.C. [USA], Apr 23 (ANI): Testing for molecular markers in the urine of kidney transplant patients could reveal whether the transplant is failing and why, according to a recent research.

Full Story >>

From urine to blood: How antibiotic resistance spreads

Updated: Apr 23, 2017 09:25 IST     

Washington D.C. [USA], Apr 23 (ANI): People with drug-resistant bacteria in their urine or stool samples are at an increased risk of developing Sepsis, a bloodstream infection that is also resistant to certain antibiotics, according to a recent study.

Full Story >>

Move over contact lenses, LASIK is better

Updated: Apr 22, 2017 18:05 IST     

Washington D.C. [USA], April 22 (ANI): Good news for those who underwent LASIK (laser-assisted in situ keratomileusis) for correction of their vision, as a recent study has found that the rate of cornea infection is lower.

Full Story >>

Early detection of oral cancer can increase survival chances

Updated: Apr 22, 2017 08:03 IST     

New Delhi [India], Apr. 22 (ANI): In today's era of booming medical advancements, the chances of survival from cancer can be increased, if it is detected at an early stage.

Full Story >>

Eman Ahmed has done miraculously well: Doctor

Updated: Apr 21, 2017 21:11 IST     

Mumbai (Maharashtra) [India], Apr 21 (ANI): 36-year-old Egyptian Eman Ahmed, who was the heaviest woman in the world at 500-plus kg until a few months ago, has lost 250kg in two months after undergoing surgery here at Saifee Hospital.

Full Story >>

Let's create awareness about liver cancer!

Updated: Apr 21, 2017 17:25 IST     

New Delhi [India], Apr 21 (ANI): The increasing liver disease is one of the most common diseases in the world.

Full Story >>

College blues? Turn to mindfulness

Updated: Apr 21, 2017 16:35 IST     

Washington D.C. [USA], Apr 21 (ANI): Heading off to college? A recent study has suggested that mindfulness may help freshmen stress less and smile more.

Full Story >>

Did you know hearing tests fail to diagnose hearing loss?

Updated: Apr 21, 2017 10:57 IST     

Washington D.C. [USA], April 21 (ANI): A team of US researchers has revealed that the traditional clinical hearing tests often fail to diagnose patients with a common form of inner ear damage, which otherwise might be detected by some behavioural tests.

Full Story >>

Washington D.C. [USA], April 21 (ANI): Canadian researchers have found that people with multiple sclerosis start showing symptoms of something wrong, five years before the onset of disease.

Full Story >>

Lifelong learning may turn clock back on your aging brain

Updated: Apr 20, 2017 23:17 IST     

Washington D.C. [USA], Apr 20 (ANI): You may want to stimulate your brain in early life as a recent study has found that it may help stay mentally healthy in older age.

Full Story >>

New Delhi [India], Apr 20 (ANI): A 24-year-old multiple sclerosis patient recently got another chance at life after undergoing a bone marrow transplantation.

Full Story >>

A weapon against Alzheimer's in your womb?

Updated: Apr 20, 2017 17:13 IST     

Washington D.C. [USA], Apr 20 (ANI): Think your memory is starting to slip? A protein found in umbilical cord blood may help turn back the clock on mental ageing.

Full Story >>