Mon, Mar 27, 2017 | updated 10:19 AM IST

Fruit flies could be helpful to fight cervical cancer caused by HPV

Updated: Aug 20, 2016 16:02 IST

Washington D.C, Aug 20 (ANI): HPV (Human papillomavirus), one of the most common sexually transmitted infections in the United States, has been identified as a primary cause of cervical cancer in women.

Following the findings, an international team of researchers led by the University of Missouri, has completed studies on fruit flies with a condition that resembles a form of HPV-induced cancer.

The fly models, developed by the team may help scientists understand the underlying mechanism by which this virus can cause cancer as well as identify potential drug treatments.

Professor Bing Zhang, while speaking about the study, said, "This is the first model of an HPV-induced cancer in fruit flies. This new model will help scientists understand the molecular and biochemical pathways involved in tumor growth and malignancy caused by HPV as well as screen for potential drug targets."

Previous studies conducted in human cells and in mice have shown that the virus enters the body through the skin and produces several oncoproteins, which are proteins that can transform a normal cell into a tumor cell. One of these viral oncoproteins, called 'E6', plays an important role during the later stages of tumor formation and metastasis.

The study, led by Mojgan Padash, introduced the viral E6 oncoprotein and a human protein that is necessary for E6-induced cancer into fruit flies. The proteins caused severe abnormalities in the epithelial, or skin, cells of the fruit flies.

The researchers also show reduced levels of the same suite of proteins targeted by E6 in humans. Further experiments done in human cell lines with the fruit fly version of the E6-targeted proteins yielded similar results, providing additional evidence that E6 works the same in flies as it does in humans.

Although cellular abnormalities resulted, the scientists found that the E6 proteins were not sufficient enough to cause tumors in flies. Since it is thought that mutations in a human oncoprotein, called Ras, may contribute to E6-mediated tumor development in humans, the researchers introduced this third protein into the flies. With all three proteins present, the flies developed malignant tumors that metastasized.

"The take home message is that the same key molecular players that underlie HPV E6-mediated cancer in humans do the same things in flies. Practically speaking, this means we can now use this fly model to identify other essential components that contribute to E6-mediated tumorigenesis, which has the potential to translate into therapies for HPV-induced cancers," he said.

The study appeared in PLoS Pathogens. (ANI)

Washington D.C. [USA], Mar. 26 (ANI): Attention dog lovers! With just six months of training, a German Shepherd can accurately detect breast cancer, a study finds.

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Washington D.C. [USA], Mar. 26 (ANI): After spending the whole day in school, ask your kids to play for ten minutes daily as it can reduce your child's risk of having heart disease, stroke and diabetes, in adulthood, reveals a study.

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Washington D.C. [U.S.A.], Mar. 27 (ANI): After a heart attack, ask your grandparents to make their bed, do laundry or carry groceries as it may start the road to recovery soon, suggests a study.

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Washington D.C. [USA], Mar. 26 (ANI): A recent study has found that a sleepless night impairs your ability to interpret subtle expressions of happiness and sadness.

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Washington D.C. [USA], Mar. 26 (ANI): When it comes to new moms' workout programs, less is more and so, according to a Kansas State University researcher, new moms may need a bit more flexibility and support to ease back into exercise after giving birth.

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New approach to diagnosing mental disorders

Updated: Mar 26, 2017 10:48 IST

Washington D.C. [USA], Mar. 26 (ANI): A consortium of psychiatrists and psychologists has proposed a new approach to diagnosing mental disorders.

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Washington D.C. [USA], Mar. 26 (ANI): Boosting natural brain opioids may be a better way to treat anxiety, according to a recent study.

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Fecal transplant offers hope for autistic kids

Updated: Mar 26, 2017 09:37 IST

Washington D.C. [USA], Mar. 26 (ANI): In this new era of medical therapy dawning, fecal transplants are poised to help fight a range of conditions, from deadly superbugs to obesity and now, autism is in the firing line.

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Thiruvallur (Chennai) [India], Mar. 25 (ANI): A highly contagious viral disease of cattle and swine, Foot-and-Mouth Disease (FMD) has affected Karani village on the outskirts of Tamil Nadu's Tiruvallur district.

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New Delhi [India], Mar. 25 (ANI): The findings of the National Family Health Survey 2015-16 confirm what we all knew from clinical evidence - that hypertension has become a major health concern among the Indian population, with as many as 22% Indians hypertensive.

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Washington D.C. [USA], Mar. 25 (ANI): A prescription weight-loss medication can decrease the urge to use opiates such as oxycodone, according to a recent study.

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Washington D.C. [USA], Mar. 25 (ANI): A team of researchers has discovered a new gene that is associated with Tau accumulation, which is one of the defining features of Alzheimer disease (AD).

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Washington D.C. [USA], Mar. 25 (ANI): Scientists have found that stem cell therapy repairs damaged lungs - raising hopes of a cure for the crippling chronic obstructive pulmonary disease (COPD) and cystic fibrosis.

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New method can cut dental implant failure

Updated: Mar 25, 2017 09:34 IST

Washington D.C. [USA], Mar. 25 (ANI): A team of researchers has come up with a new method to reduce dental implant failure.

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Washington D.C. [USA], Mar. 25 (ANI): A team of researchers has come up with a fluorogenic probe that can detect the activity of multidrug-resistant pathogens in an assay system.

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Virus hydrophobicity can help purify vaccines

Updated: Mar 25, 2017 07:46 IST

Washington D.C. [USA], Mar. 25 (ANI): A team of researchers has found that hydrophobic proteins on virus surfaces can help purify vaccines.

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Washington D.C. [USA], Mar. 25 (ANI): A team of researchers has shed light on why survivors of childhood brain tumours may be prone to heart disease, stroke, type 2 diabetes and early death.

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New Delhi [India], Mar. 24 (ANI): Continuing its efforts to raise awareness on tuberculosis and its diagnosis, Division of Clinical Microbiology & Molecular Medicine Department of Laboratory Medicine, AIIMS, and BD (Becton Dickinson India) for the third consecutive year organized a symposium today on "challenges in diagnosis and eradication of tuberculosis".

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New Delhi [India], Mar. 24 (ANI): On the solemn occasion of World Tuberculosis (TB) Day, Members of Parliament, policymakers, TB patients, survivors, and citizens of the civil society gathered at India Gate on Thursday, March 23 to pay tribute to the nearly five lakh lives lost due to this disease last year.

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