Thu, Apr 27, 2017 | updated 06:55 AM IST

Fruit flies could be helpful to fight cervical cancer caused by HPV

Updated: Aug 20, 2016 16:02 IST      
Fruit flies could be helpful to fight cervical cancer caused by HPV

Washington D.C, Aug 20 (ANI): HPV (Human papillomavirus), one of the most common sexually transmitted infections in the United States, has been identified as a primary cause of cervical cancer in women.

Following the findings, an international team of researchers led by the University of Missouri, has completed studies on fruit flies with a condition that resembles a form of HPV-induced cancer.

The fly models, developed by the team may help scientists understand the underlying mechanism by which this virus can cause cancer as well as identify potential drug treatments.

Professor Bing Zhang, while speaking about the study, said, "This is the first model of an HPV-induced cancer in fruit flies. This new model will help scientists understand the molecular and biochemical pathways involved in tumor growth and malignancy caused by HPV as well as screen for potential drug targets."

Previous studies conducted in human cells and in mice have shown that the virus enters the body through the skin and produces several oncoproteins, which are proteins that can transform a normal cell into a tumor cell. One of these viral oncoproteins, called 'E6', plays an important role during the later stages of tumor formation and metastasis.

The study, led by Mojgan Padash, introduced the viral E6 oncoprotein and a human protein that is necessary for E6-induced cancer into fruit flies. The proteins caused severe abnormalities in the epithelial, or skin, cells of the fruit flies.

The researchers also show reduced levels of the same suite of proteins targeted by E6 in humans. Further experiments done in human cell lines with the fruit fly version of the E6-targeted proteins yielded similar results, providing additional evidence that E6 works the same in flies as it does in humans.

Although cellular abnormalities resulted, the scientists found that the E6 proteins were not sufficient enough to cause tumors in flies. Since it is thought that mutations in a human oncoprotein, called Ras, may contribute to E6-mediated tumor development in humans, the researchers introduced this third protein into the flies. With all three proteins present, the flies developed malignant tumors that metastasized.

"The take home message is that the same key molecular players that underlie HPV E6-mediated cancer in humans do the same things in flies. Practically speaking, this means we can now use this fly model to identify other essential components that contribute to E6-mediated tumorigenesis, which has the potential to translate into therapies for HPV-induced cancers," he said.

The study appeared in PLoS Pathogens. (ANI)

Lung for Long: Gasp No More

Updated: Apr 26, 2017 18:45 IST     

New Delhi [India], Apr 26 (ANI-Businesswire India): Lungs in Delhi seem to be in dire straits. In the midst of ever thickening air pollution and lifestyle gone astray, lung power is ebbing fast. Data emerging from April 25 lung health camp organized in iconic Press Club of India (PCI) on the occasion of World Asthma Day pressed panic button as regards lung health of the capital city.

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Risk of obesity influenced by changes in our genes

Updated: Apr 26, 2017 15:22 IST     

New Delhi [India], Apr 26 (ANI): According to new study, a child's risk of obesity while growing up can be influenced by modifications to their DNA prior to birth.

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Patient with rare knee cancer undergoes life saving surgery

Updated: Apr 26, 2017 13:52 IST     

New Delhi [India], Apr 26 (ANI): A resident of Ganganager, in Rajasthan, was diagnosed of Large Soft Tissue Sarcoma (9Kg), with Neuro Vascular involvement.

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Here`s how protein impacts intellectual disability

Updated: Apr 26, 2017 07:36 IST     

Washington D.C. [USA], Apr 26 (ANI): A new study has paved the way for the potential treatments of intellectual disability and other neurodevelopmental disorders.

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Stem cells can help identify neuronal defects, suggests Study

Updated: Apr 25, 2017 12:26 IST     

Washington D.C. [USA], Apr 25 (ANI): According to a recent study, the researchers used stem cells derived from patients with Angelman syndrome to identify the underlying cellular defects that cause the rare neurogenetic disorder.

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#WorldMalariaDay: Effective steps to prevent Malaria

Updated: Apr 25, 2017 11:01 IST     

New Delhi [India], Apr 25 (ANI): The theme for World Malaria Day this year is "End Malaria for Good".

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Artificial Intelligence may help in diagnosing Tuberoculosis

Updated: Apr 25, 2017 11:01 IST     

Washington D.C. [USA], Apr 25 (ANI): If you are a patient of Tuberculosis, then we might have some good news for you.

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London [UK], Apr 25 (ANI): According to a new study, only one in five victims with serious injuries caused by child abuse in England and Wales gets treated at a major trauma centre.

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Gene reveals cause of fatal childhood disorder: Study

Updated: Apr 24, 2017 17:51 IST     

New Delhi [India], Apr 24 (ANI): A gene, involved in brain development, which can lead to severe disability and infant death, has been identified by scientists.

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Alcohol: the modern age liver killer

Updated: Apr 24, 2017 17:51 IST     

New Delhi [India], Apr 24 (ANI): Alcohol is predominantly metabolized through liver, hence its cumulative toxicity over years play important role in liver diseases or pancreatic diseases.

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Washington D.C. [USA], April 24 (ANI): Due to increasing deaths because of prostate cancer among men, US researchers have suggested a special screening more frequently and at an early age to avoid the development of preclinical prostate cancer - that is not symptomatic - to advanced stages.

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Love guzzling diet sodas? Here is why you should NOT

Updated: Apr 24, 2017 07:02 IST     

New York [U.S.], Apr. 24 (ANI): Still downing gallons of diet soda despite knowing that it wrecks your body? Maybe the knowledge of artificially sweetened beverages taking a toll on your brain as well ought to make an impact on your unhealthy habit.

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Washington D.C. [USA], Apr 23 (ANI): A recent study has demonstrated that in the general population, central obesity, insulin resistance, diabetes, lipid abnormalities and high alcohol consumption were the strongest predictors of severe liver disease.

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Breastmilk may help detect your cancer risk

Updated: Apr 23, 2017 11:50 IST     

Washington D.C. [USA], Apr 23 (ANI): Breastmilk might offer clues about a woman's cancer risk, according to a recent research.

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Soon, new weapon in war against obesity

Updated: Apr 23, 2017 11:14 IST     

Washington D.C. [USA], Apr 23 (ANI): A team of scientists has uncovered a potential approach to combat obesity.

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Turns out, being obese is worse than smoking

Updated: Apr 23, 2017 10:52 IST     

Washington D.C. [USA], Apr 23 (ANI): You may want to shed those extra kilos as a recent study has found obesity as a top cause of preventable life-years lost.

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Washington D.C. [USA], Apr 23 (ANI): Testing for molecular markers in the urine of kidney transplant patients could reveal whether the transplant is failing and why, according to a recent research.

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From urine to blood: How antibiotic resistance spreads

Updated: Apr 23, 2017 09:25 IST     

Washington D.C. [USA], Apr 23 (ANI): People with drug-resistant bacteria in their urine or stool samples are at an increased risk of developing Sepsis, a bloodstream infection that is also resistant to certain antibiotics, according to a recent study.

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Move over contact lenses, LASIK is better

Updated: Apr 22, 2017 18:05 IST     

Washington D.C. [USA], April 22 (ANI): Good news for those who underwent LASIK (laser-assisted in situ keratomileusis) for correction of their vision, as a recent study has found that the rate of cornea infection is lower.

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Early detection of oral cancer can increase survival chances

Updated: Apr 22, 2017 08:03 IST     

New Delhi [India], Apr. 22 (ANI): In today's era of booming medical advancements, the chances of survival from cancer can be increased, if it is detected at an early stage.

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