Sun, Jul 23, 2017 | updated 04:15 AM IST

Study opens door to treatment of oesophageal cancer

Updated: Sep 06, 2016 17:31 IST      
Study opens door to treatment of oesophageal cancer

Washington D.C. [USA], Sept. 6 (ANI): In a recent study, scientists

have discovered that oesophageal cancer can be classified into three

different subtypes, paving the way for testing targeted treatments

tailored to patients' disease for the first time.

It could help find drugs that target specific weaknesses in each

subtype of the disease, which could make treatment more effective and

boost survival.

The scientists looked at the complete genetic make-up of 129

oesophageal cancers and were able to subdivide the disease into three

distinct types based on patterns detected in the DNA of the cancer

cells called signatures.

The first subtype they found had faults in their DNA repair pathways.

Damage to this pathway is known to increase the risk of breast,

ovarian and prostate cancers.

Patients with this subtype may benefit from a new family of drugs,

called PARP inhibitors, that kill cancer cells by exploiting this

weakness in their ability to repair DNA.

The second subtype had a higher number of DNA mistakes and more immune

cells in the tumours, which suggests these patients could benefit from

immunotherapy drugs already showing great promise in a number of

cancer types such as skin cancer.

The final subtype had a DNA signature that is mainly associated with

the cell ageing process and means this group might benefit from drugs

targeting proteins on the surface of the cancer cells which make cells


Lead researcher Professor Rebecca Fitzgerald, said "Our study suggests

we could make changes to the way we treat oesophageal cancer. Targeted

treatments for the disease have so far not been successful, and this

is mostly down to the lack of ways to determine which patients might

benefit from different treatments. These new findings give us a

greater understanding of the DNA signatures that underpin different

subtypes of the disease and means we could better tailor treatment."

He added, "The next step is to test this approach in a clinical trial.

The trial would use a DNA test to categorise patients into one of the

three groups to determine the best treatments for each group and move

away from a one-size-fits-all approach."

Each year around 8,800 people are diagnosed with oesophageal cancer in

UK and just 12 percent survive their disease for at least 10 years.

Cancer Research UK has prioritised research into oesophageal cancer to

help more people survive the disease by bringing people together,

building infrastructure and developing the next generation of research


Co-researcher Peter Johnson said "Being able to distinguish distinct

types of oesophageal cancer is a genuinely new discovery from this

work. For the first time we may be able to identify and test targeted

treatments designed to exploit the cancer's specific weaknesses."

He added, "Although survival rates from oesophageal cancer have been

slowly rising in the last few years they are still far too low, and

this research points the way to a completely new way of understanding

and tackling the disease."

The research was published in Nature Genetics. (ANI)

This is your brain on depression

Updated: Jul 22, 2017 13:55 IST     

Washington D.C. [USA], July 22 (ANI): Got the blues? According to a recent study, depression can change the structure of your brain.

Full Story >>

Rush-hour pollution may be more harmful than thought

Updated: Jul 22, 2017 10:57 IST     

Washington D.C. [USA], Jul 22 (ANI): Turns out, rush-hour commuters may be in for a double whammy of pollution exposure.

Full Story >>

TRAC, MedGenome announce Cancer Immunotherapy solution

Updated: Jul 22, 2017 06:24 IST     

New Delhi [India], July 22 (ANI): Toronto Recombinant Antibody Centre (TRAC) from the University of Toronto, Canada agreed to license MedGenome's patented cancer immunotherapy solution OncoPept to develop biomarkers for their drug candidates against immune modulators to treat cancer.

Full Story >>

Are some people genetically programmed to be depressed?

Updated: Jul 21, 2017 09:48 IST     

Washington D.C. [USA], Jul 21 (ANI): It's a sombre thought, but it seems that some of us are born more likely to be depressed.

Full Story >>

Washington D.C. [USA], Jul 21 (ANI): A team of researchers has come up with a new imaging technique that can diagnose cardiac sarcoidosis much more accurately than traditional tests.

Full Story >>

Ahmedabad (Gujarat) [India], July 21 (ANI): Ayurveda is a form of alternative medicine which seeks to treat and integrate body, mind and spirit using a comprehensive holistic approach especially by emphasizing diet, herbal remedies, exercise, meditation, breathing, and physical therapy.

Full Story >>

Washington D.C. [USA], Jul 20 (ANI): When it comes to faring well after chemotherapy, a cancer patient's social interaction matters, according to a recent study.

Full Story >>

New radiotherapy find offers hope to cancer patients

Updated: Jul 20, 2017 10:06 IST     

Washington D.C. [USA], Jul 20 (ANI): An exciting discovery in the cancer treatment is having dramatic results.

Full Story >>

New strategy could yield more effective flu shots

Updated: Jul 20, 2017 09:46 IST     

Washington D.C. [USA], Jul 20 (ANI): A boosting skin vaccination with a biodegradable microneedle patch and protein constructed from sequences of influenza virus subtypes could improve the effectiveness of conventional influenza vaccines, according to a recent study.

Full Story >>

Revealed! Best time to sleep to wake up feeling refreshed

Updated: Jul 20, 2017 04:09 IST     

London [UK], July 20 (ANI): The secret of a good night's sleep has finally been unveiled!

Full Story >>

Anxiety drug may help you with fear of social rejection

Updated: Jul 19, 2017 14:22 IST     

Washington D.C. [USA], July 19 (ANI): A team of researchers has found that low doses of anxiety disorder-reducing drug can help highly-anxious people overcome their fear of being over-looked and rejected socially.

Full Story >>

Washington D.C. [USA], July 19 (ANI): Good news! A new technology may help to non-invasively predict children or newborn at risk of an asthma attack.

Full Story >>

Your poor sleep may increase risk of Alzheimer's: Study

Updated: Jul 19, 2017 10:08 IST     

Washington D.C. [USA], July 19 (ANI): Beware! Breathing problems during sleep may be a signal of an increased risk for Alzheimer's disease, warns a study.

Full Story >>

Indian population, carrier of hepatitis B: Study

Updated: Jul 18, 2017 20:01 IST     

New Delhi [India], July 18 (ANI): Viral hepatitis is inflammation and damage of the liver by viruses , most commonly hepatotrophic (predominantly with an affinity for attacking the liver - Hepatitis A , B , C , D , E ) or non hepatotrophic viruses (Generalized involvement of human body with liver as a target tissue seen with Dengue virus , Chikungunya etc.).

Full Story >>

This monsoon, let's be HepAware!

Updated: Jul 18, 2017 18:01 IST     

New Delhi [India], July 18 (ANI): Hepatitis A is mild to the moderate viral disorder of the liver which is affected by the consumption of contaminated food and water. Unfortunately, monsoons are the best time when air/water borne infections are at its peak.

Full Story >>

Washington D.C. [USA], July 18 (ANI): If your grandparents are suffering from dementia, then you can help them by interacting with them about their interests for an hour a week and improve their quality life.

Full Story >>

New Delhi [India], July 17 (ANI): Commemorating its 21st Founder's Day and in an endeavor to promote healthy lifestyle, Pushpawati Singhania Hospital & Research Institute (PSRI) a multi-specialty hospital here organized free health check-up camps and school wellness programme.

Full Story >>

Here's how weekly social hour can help dementia patients

Updated: Jul 17, 2017 11:49 IST     

Washington D.C. [USA], Jul 17 (ANI): Person-centred activities combined with just one hour a week of social interaction can improve quality of life and reduce agitation for people with dementia living in care homes, while saving money, according to a recent study.

Full Story >>

Combo therapy better than drug alone against Alzheimer's

Updated: Jul 17, 2017 11:34 IST     

Washington D.C. [USA], Jul 17 (ANI): Combining a specific care management program with a commonly-prescribed drug for Alzheimer's disease is better at turning back the clock on the ageing brain than medication alone, according to a recent study.

Full Story >>

Washington D.C. [USA], Jul 17 (ANI): Nearly 30 percent of stroke patients are refusing to take life-saving statins because they are worried about the side effects, according to a recent study.

Full Story >>