Wed, Mar 29, 2017 | updated 10:57 AM IST

Boosting the potency of broccoli may help treating age-related vision loss

Updated: Jul 07, 2016 16:24 IST

Washington D.C., July 7 (ANI): Buck researchers have found that boosting the potency of broccoli-related compound by ten times could help treating age-related macular degeneration (AMD), a prime cause of vision loss.

The study highlighted the role of lipid metabolism in maintaining the health of the retina, claiming that palmitoleic acid also had protective effects on retinal cells in culture and in mice.

Researchers found that the "good-for-you" compound in broccoli which prompted the inquiry is indole-3-carbinol (I3C) and is currently being studied for cancer prevention.

As per study, I3C helps clear cells of environmental toxins by activating the aryl hydrocarbon receptor (AhR) protein which upregulates pathways involved in chemical detoxification. AhR, which declines with age, is important for detoxifying the retina.

Lead author Arvind Ramanathan and his team came up with 2,2?-aminophenyl indole (2AI) which is ten times more potent than I3C.

"2AI protected human retinal cells in culture from stress. And it also protected retinal cells in mice from light-mediated damage. We are very excited about the potential for 2AI and look forward to developing it further, he said.

Senior author Deepak Lamba, MBBS, PhD said, 2AI prevented cell death in the retinas of mice that were exposed to light stress.

"Our next step is to study the functional outcomes of treatment with 2AI, something I am eager to do because environmental stress is the major contributor to age-related vision loss," he said.

The study is published in Journal Scientific Reports. (ANI)

Ranchi [India], Mar. 28 (ANI): Health Minister of Jharkhand, Ramchandra Chandravanshi has recently claimed that the state has come a long way from the day when Jharkhand was on 18th number among states as far as their healthcare services were concerned. It now stands third in the country, according to an independent survey.

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Washington D.C. [USA], Mar. 28 (ANI): Exposure to fungal product, called aflatoxin, is believed to cause up to 80 percent of liver cancer cases in many parts of the world.

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Washington D.C. [USA], Mar. 26 (ANI): Attention dog lovers! With just six months of training, a German Shepherd can accurately detect breast cancer, a study finds.

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Washington D.C. [USA], Mar. 26 (ANI): A recent study has found that a sleepless night impairs your ability to interpret subtle expressions of happiness and sadness.

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Washington D.C. [USA], Mar. 26 (ANI): When it comes to new moms' workout programs, less is more and so, according to a Kansas State University researcher, new moms may need a bit more flexibility and support to ease back into exercise after giving birth.

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New approach to diagnosing mental disorders

Updated: Mar 26, 2017 10:48 IST

Washington D.C. [USA], Mar. 26 (ANI): A consortium of psychiatrists and psychologists has proposed a new approach to diagnosing mental disorders.

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Washington D.C. [USA], Mar. 26 (ANI): Boosting natural brain opioids may be a better way to treat anxiety, according to a recent study.

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Fecal transplant offers hope for autistic kids

Updated: Mar 26, 2017 09:37 IST

Washington D.C. [USA], Mar. 26 (ANI): In this new era of medical therapy dawning, fecal transplants are poised to help fight a range of conditions, from deadly superbugs to obesity and now, autism is in the firing line.

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Thiruvallur (Chennai) [India], Mar. 25 (ANI): A highly contagious viral disease of cattle and swine, Foot-and-Mouth Disease (FMD) has affected Karani village on the outskirts of Tamil Nadu's Tiruvallur district.

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New Delhi [India], Mar. 25 (ANI): The findings of the National Family Health Survey 2015-16 confirm what we all knew from clinical evidence - that hypertension has become a major health concern among the Indian population, with as many as 22% Indians hypertensive.

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Washington D.C. [USA], Mar. 25 (ANI): A prescription weight-loss medication can decrease the urge to use opiates such as oxycodone, according to a recent study.

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Washington D.C. [USA], Mar. 25 (ANI): A team of researchers has discovered a new gene that is associated with Tau accumulation, which is one of the defining features of Alzheimer disease (AD).

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Washington D.C. [USA], Mar. 25 (ANI): All it takes is the flip of a protein "switch" within the tiny wire-like capillaries of the brain to increase the blood flow that ensures optimal brain function.

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Washington D.C. [USA], Mar. 25 (ANI): Scientists have found that stem cell therapy repairs damaged lungs - raising hopes of a cure for the crippling chronic obstructive pulmonary disease (COPD) and cystic fibrosis.

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New method can cut dental implant failure

Updated: Mar 25, 2017 09:34 IST

Washington D.C. [USA], Mar. 25 (ANI): A team of researchers has come up with a new method to reduce dental implant failure.

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Washington D.C. [USA], Mar. 25 (ANI): A team of researchers has come up with a fluorogenic probe that can detect the activity of multidrug-resistant pathogens in an assay system.

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Virus hydrophobicity can help purify vaccines

Updated: Mar 25, 2017 07:46 IST

Washington D.C. [USA], Mar. 25 (ANI): A team of researchers has found that hydrophobic proteins on virus surfaces can help purify vaccines.

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Washington D.C. [USA], Mar. 25 (ANI): A team of researchers has shed light on why survivors of childhood brain tumours may be prone to heart disease, stroke, type 2 diabetes and early death.

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New Delhi [India], Mar. 24 (ANI): Continuing its efforts to raise awareness on tuberculosis and its diagnosis, Division of Clinical Microbiology & Molecular Medicine Department of Laboratory Medicine, AIIMS, and BD (Becton Dickinson India) for the third consecutive year organized a symposium today on "challenges in diagnosis and eradication of tuberculosis".

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New Delhi [India], Mar. 24 (ANI): On the solemn occasion of World Tuberculosis (TB) Day, Members of Parliament, policymakers, TB patients, survivors, and citizens of the civil society gathered at India Gate on Thursday, March 23 to pay tribute to the nearly five lakh lives lost due to this disease last year.

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