Mon, May 29, 2017 | updated 03:43 AM IST

Is popping antibiotics a way to beat Alzheimer's?

Updated: Jul 22, 2016 13:31 IST      
Is popping antibiotics a way to beat Alzheimer's?

Washington D.C, Jul 22 (ANI): Warding off Alzheimer's disease could one day be as easy as popping antibiotics, suggests a new study.

In the University of Chicago study, long-term treatment with broad spectrum antibiotics decreased levels of amyloid plaques, a hallmark of Alzheimer's disease, and activated inflammatory microglial cells in the brains of mice.

The study also showed significant changes in the gut microbiome after antibiotic treatment, suggesting the composition and diversity of bacteria in the gut play an important role in regulating immune system activity that impacts progression of Alzheimer's disease.

"We're exploring very new territory in how the gut influences brain health," said senior author Sangram Sisodia, adding: "This is an area that people who work with neurodegenerative diseases are going to be increasingly interested in, because it could have an influence down the road on treatments."

Two of the key features of Alzheimer's disease are the development of amyloidosis, accumulation of amyloid-Beta (ABeta) peptides in the brain, and inflammation of the microglia, brain cells that perform immune system functions in the central nervous system. Buildup of ABeta into plaques plays a central role in the onset of Alzheimer's, while the severity of neuro-inflammation is believed to influence the rate of cognitive decline from the disease.

For this study, Sisodia and his team administered high doses of broad-spectrum antibiotics to mice over five to six months. At the end of this period, genetic analysis of gut bacteria from the antibiotic-treated mice showed that while the total mass of microbes present was roughly the same as in controls, the diversity of the community changed dramatically.

The antibiotic-treated mice also showed more than a two-fold decrease in ABeta plaques compared to controls, and a significant elevation in the inflammatory state of microglia in the brain. Levels of important signaling chemicals circulating in the blood were also elevated in the treated mice.

Sisodia cautioned, "There's probably not going to be a cure for Alzheimer's disease for several generations, because we know there are changes occurring in the brain and central nervous system 15 to 20 years before clinical onset," adding: "We have to find ways to intervene when a patient starts showing clinical signs, and if we learn how changes in gut bacteria affect onset or progression, or how the molecules they produce interact with the nervous system, we could use that to create a new kind of personalized medicine."

The study is published in Scientific Reports. (ANI)

Soon, an accurate, cheap genetic test for anal cancer

Updated: May 28, 2017 13:56 IST     

Washington D.C. [USA], May 28 (ANI): A new genetic test could be an accurate and inexpensive way to find and treat those at highest risk of anal cancer - a disease with growing incidence in women, men who have sex with men (MSM) and people with HIV.

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Fight against leprosy: Efforts honoured with ICN award

Updated: May 28, 2017 13:44 IST     

New Delhi [India], May 28 (ANI): The International Council of Nurses (ICN) presented its Health and Human Rights Award to Yohei Sasakawa, Chairman of the Nippon Foundation, at the 2017 ICN Congress in Barcelona, Spain, on May 27.

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Higher BMI can cause cardiovascular problems for youngsters

Updated: May 28, 2017 08:56 IST     

Washington D.C. [USA], May 28 (ANI): A recent study shows that higher than normal Body Mass Index (BMI) may cause worse cardiovascular health in those aged as young as 17.

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Probiotics helpful in treating depression: Study

Updated: May 28, 2017 08:36 IST     

Washington D.C. [USA], May 28 (ANI): According to a new study, adults with irritable bowel syndrome (IBS) reported improvements from co-existing depression, when they took a specific pro-biotic than adults with IBS who took a placebo.

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Exposure to diesel pollution ups risk of heart attack

Updated: May 28, 2017 07:10 IST     

Washington D.C. [USA], May 28 (ANI): A word of caution; avoid places with heavy traffic or try to find a different route as a study has warned that exposure to diesel pollution causes heart attack, heart failure and death.

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Statins improves heart structure and function: Study

Updated: May 27, 2017 23:02 IST     

Washington D.C. [USA], May 27 (ANI): Briton researchers have found that group of drugs, which act to reduce levels of cholesterol in the blood, is linked to improved heart structure and its function.

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Rock climbing for three hours a week may treat depression

Updated: May 27, 2017 19:14 IST     

Washington D.C. [USA], May 27 (ANI): A team of researchers have revealed that bouldering, a form of rock climbing performed without the use of ropes or harnesses, for three hours a week may help to treat depression.

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Beware! Recreational cannabis doubles the risk of gum disease

Updated: May 27, 2017 16:56 IST     

Washington D.C. [USA], May 27 (ANI): Beware! A study has warned that frequent recreational use of cannabis, including marijuana, hashish, and hash oil, doubles the risk of gum disease.

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Bengaluru (Karnataka) [India], May 27 (ANI): BGS Gleneagles Global Hospitals, a Parkway Pantai enterprise, successfully pioneered the day care Bone Marrow Transplant (BMT) transplant program for low risk transplants like autologous transplant for multiple myeloma and mini-allo transplant for various hematological disorders.

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New hope for stroke patients with disabilities

Updated: May 27, 2017 11:22 IST     

Washington D.C.[USA], May 27 (ANI): Stroke patients left with disabilities have been offered new hope as scientists have developed mind-controlled device that helps them retrain brains to move paralyzed hands.

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Washington D.C. [USA], May 27 (ANI): According to a new study, people suffering from HIV tend to spend more time in therapy to manage the chronic condition.

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New Delhi [India], May 26 (ANI): Latest robotic surgery may work as a boon for patients suffering from early stage oropharyngeal carcinoma (cancer of the mouth, neck and throat).

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23-year-old suffers severe heart attack due to smoking

Updated: May 26, 2017 16:01 IST     

New Delhi [India], May 26 (ANI): With several reasons attributing to a paradigm shift in the age groups suffering from heart attacks to younger age brackets, tobacco induced cardiac arrests rate as one of the topmost ones.

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New Delhi [India], May 26 (ANI): According to statistics, India has the third largest Muslim population in the world. The month of Ramadan is about to begin and a vast majority of this population will be fasting for a large number of days.

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Frequent recreational weed puts your mouth at risk

Updated: May 26, 2017 08:12 IST     

Washington D.C. [USA], May 26 (ANI): Frequent recreational use of cannabis, including marijuana, hashish, and hash oil, ups the risk of gum disease, a recent study has found.

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Washington D.C. [USA], May 25 (ANI): A study, presented at EuroCMR, says that chemotherapy-induced cardiomyopathy react more on men than women.

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New Delhi [India], May 25 (ANI): Envisioning a leap in emergency care, Aster DM Healthcare on Thursday launched its most novel and unique concept, the 'Aster Emergency' app, which will offer real-time interface between the patient in emergency and a GPS-enabled Aster 'Responder'.

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New Delhi [India], May 25 (ANI-BusinessWireIndia): Everyuth Naturals, a pioneer and a leading skincare brand known for its natural ingredients and effective products has announced the re-launch of its flagship product in the face wash category with-the new improved Everyuth Tulsi Turmeric Face Wash.

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New Delhi [India], May 25 (ANI): A Sutureless Valve Replacement surgery was recently performed on a 78 year old patient by Global Hospitals, Mumbai.

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Suicide rates among people with autism on rise

Updated: May 25, 2017 11:26 IST     

Washington D.C. [USA], May 25 (ANI): According to a recent study, suicide rates among autism patients have reached 'worryingly' high levels.

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