Sat, Mar 25, 2017 | updated 07:26 AM IST

Hope for Alzheimer's cure as scientists develop protein

Updated: Jul 25, 2016 10:18 IST

Washington D.C, Jul 25 (ANI): A newly-developed protein, which will help scientists to understand why nerve cells die in people with Alzheimer's disease, could pave way for new treatment strategies.

In Alzheimer's patients, Amyloid-beta (Abeta) proteins stick together to make amyloid fibrils that form clumps between neurons in the brain. It's believed that the build-up of these clumps causes brain cells to die, leading to the cognitive decline in patients suffering from the disease.

It is not known why this particular protein's "stickiness" causes cells to die and scientists have been unable to properly test whether the sticky clumps of Abeta proteins have different effects, compared with individual proteins that are not stuck together.

Now, University of Sussex scientists have created a new protein, which closely resembles the Abeta protein in size and shape, but contains two different amino acids (the building blocks that proteins are made up of).

These changes mean that the new protein does not form amyloid fibres or sticky clumps, and, unlike Abeta, is not toxic to nerve cells, according to the study.

Lead author Karen Marshall said: "Understanding how the brain protein Abeta causes nerve cell death in Alzheimer's patients is key if we are to find a cure for this disease. Our study clearly shows that the aggregation of Abeta into bigger species is critical in its ability to kill cells. Stopping the protein aggregating in people with Alzheimer's could slow down the progression symptoms of the disease. We hope to work towards finding a strategy to do this in the lab and reverse the damaging effects of toxic Abeta."

Senior author Louise Serpell said: "This is a really exciting new tool that will contribute to research to uncover the causes for Alzheimer's disease and enable tangible progress to be made towards finding targets for therapy."

The study is published in journal Scientific Reports. (ANI)

Washington D.C. [USA], Mar. 25 (ANI): A team of researchers has shed light on why survivors of childhood brain tumours may be prone to heart disease, stroke, type 2 diabetes and early death.

Full Story >>

New Delhi [India], Mar. 24 (ANI): Continuing its efforts to raise awareness on tuberculosis and its diagnosis, Division of Clinical Microbiology & Molecular Medicine Department of Laboratory Medicine, AIIMS, and BD (Becton Dickinson India) for the third consecutive year organized a symposium today on "challenges in diagnosis and eradication of tuberculosis".

Full Story >>

New Delhi [India], Mar. 24 (ANI): On the solemn occasion of World Tuberculosis (TB) Day, Members of Parliament, policymakers, TB patients, survivors, and citizens of the civil society gathered at India Gate on Thursday, March 23 to pay tribute to the nearly five lakh lives lost due to this disease last year.

Full Story >>

New Delhi [India], Mar. 24 (ANI): Emergence of multi drug resistant TB and complications aggravated by high rates of co-infection with HIV-AIDS has renewed the threat of TB epidemic in India. With widespread prevalence of the infection, children experience a serious risk of contracting Tuberculosis, especially if they are under-nourished.

Full Story >>

New Delhi [India], Mar. 24 (ANI): Tuberculosis can affect any age, caste or class and it is one of the top 10 causes of death across the globe, ranking above HIV and malaria.

Full Story >>

New Delhi [India], Mar. 24 (ANI): Tuberculosis is one of the top 10 causes of death across the globe, ranking above HIV and malaria. According to the World Health Organization (WHO), in 2015, there were 10.4 million new cases of TB worldwide.

Full Story >>

London [UK], Mar. 23 (ANI): Want happy families? Then delay your decision to start a family, as a study suggests, children born to older mother experience have fewer behavioural, social and emotional problems.

Full Story >>

Washington D.C. [USA], Mar. 23 (ANI): For women, stay fit and maintain a healthy weight, as a study finds a higher waist-to-hip ratios increases the risk of ovarian cancer risk by more than a fifth.

Full Story >>

Washington D.C. [USA], Mar. 23 (ANI): A study finds that people who are born blind have heightened sense of hearing, smell and touch, suggesting that their brain "rewires" itself in the absence of visual information to boost other senses.

Full Story >>

New Delhi [India], Mar. 23 (ANI): For those suffering with age-related (degenerative) arthritis of the knee, a stage comes when all the reasonable non-operative options stops working.

Full Story >>

Hepatitis drug can help cut Ebola death rate

Updated: Mar 22, 2017 09:30 IST

Washington D.C. [USA], Mar. 22 (ANI): A class of drugs used to treat hepatitis and some forms of multiple sclerosis has shown promise in treating Ebola.

Full Story >>

Weekend surgery 'not riskier'

Updated: Mar 22, 2017 09:20 IST

Washington D.C. [USA], Mar. 22 (ANI): Day of the week has no impact on the survival chances of people undergoing emergency surgery, a new research has found.

Full Story >>

Washington D.C. [USA], Mar. 22 (ANI): Despite existing prevention methods, transmission of infections with HIV, hepatitis B, syphilis or rubella from mother to child before and during birth as well as in infancy still occur across Europe.

Full Story >>

Changes in blood may spur Alzheimer's disease

Updated: Mar 22, 2017 07:29 IST

Washington D.C. [USA], Mar. 22 (ANI): A recent study has linked changes in the vascular system to Alzheimer's disease.

Full Story >>

Spraying onto broken hearts to heal them

Updated: Mar 22, 2017 06:45 IST

Washington D.C. [USA], Mar. 22 (ANI): A team of scientist has come up with a new method that may make the heart surgeries a history.

Full Story >>

Washington D.C. [USA], Mar. 22 (ANI): With both tourism and casual "hookup" sex on the rise among college-age adults, there's an urgent need for gender-sensitive and age-appropriate sexual health campaigns that are tailored to young women's motivations for taking sexual risks while travelling, a new study has suggested.

Full Story >>

Washington D.C. [USA], Mar. 21 (ANI): Now, detecting a mosquito-borne illness will be as easy as clicking a smartphone app - thanks to a team of scientists.

Full Story >>

Washington D.C. [USA], Mar. 21 (ANI): A team of researchers has shed some light on how infections during pregnancy may interfere with the genes linked to prenatal brain development.

Full Story >>

Soon, a faster way to treat depression

Updated: Mar 21, 2017 16:02 IST

Washington D.C. [USA], Mar. 21 (ANI): A new and faster way to treat depression has come closer to reality - thanks to a team of scientists.

Full Story >>

All you need to know on Colorectal Cancer!

Updated: Mar 21, 2017 08:00 IST

New Delhi [India], Mar. 21 (ANI): Colorectal cancer is also known as colon cancer, bowel cancer. It refers to a cancerous growth, lump or a tumour in the colon and the rectum. It is the second most common cancer, after adenocarcinoma.

Full Story >>