Mon, Feb 20, 2017 | updated 11:30 PM IST

Male hormone can turn back biological clock

Updated: Jul 26, 2016 13:03 IST

Washington D.C, Jul 26 (ANI): A new study has found that sex hormones can reverse ageing by stimulating production of an enzyme naturally found in the human organism, Telomerase, which is the closest of all known substances to a "cellular elixir of youth."

The strategy was tested in patients with genetic diseases associated with mutations in the gene that codes for telomerase, such as aplastic anemia and pulmonary fibrosis. The authors said that the results suggest that the approach can combat the damage caused to the organism by telomerase deficiency.

"One of the processes associated with aging is progressive shortening of telomeres, DNA-protecting structures at the ends of chromosomes, like the plastic tips on shoelaces," said Rodrigo Calado of the University of Sao Paulo. "Each time a cell divides, its telomeres get shorter. Eventually, the cell can't replicate anymore and dies or becomes senescent. However, telomerase can keep the length of telomeres intact, even after cell division."

In practice, he added, telomere length is a laboratory measure of a cell's "age." Some cells avoid aging by using telomerase to lengthen their telomeres through the addition of DNA sequences, thereby maintaining their capacity to multiply and "stay young."

In an embryo, where tissue is still in the formative stage, telomerase is expressed by practically every cell. After this period, only cells that are constantly dividing, such as hematopoietic (blood-forming) stem cells, which can differentiate into a variety of specialized cells, continue to produce telomerase.

"Aplastic anemia is one of the diseases that can be caused by telomerase deficiency," Calado said. "Bone marrow stem cells age prematurely and fail to produce enough red blood cells, white blood cells and platelets, making the patient dependent on blood transfusions and more susceptible to infections."

"The study we've just published was designed to find out whether the effect we'd observed in the lab also occurred in humans, and the results indicate that it does," Calado noted.

Instead of estrogen, the researchers treated the patients with androgen, he explained, because it has long been used as a drug in cases of congenital anemia and offers the advantage of stimulating an increase in the mass of hemoglobin (red blood cells), which estrogen cannot do.

Although the results of the study suggest that drugs can be used to reverse one of the biological drivers of aging, it is not yet clear whether the benefits of treatment would surpass the risks in healthy people, especially if the treatment involved the use of sex hormones.

Some groups, such as patients undergoing chemotherapy or radiotherapy, may benefit from drugs that stimulate telomerase in the future.

The study appears in New England Journal of Medicine. (ANI)

New Delhi [India], Feb. 20 (ANI): With rising life expectancy, increasingly sedentary lifestyles and surge in incidence of obesity, India is also witnessing a resultant rise in orthopedic problems as a natural corollary.

Full Story >>

Children inherit obesity from parents: Study

Updated: Feb 20, 2017 14:54 IST

Washington D.C. (USA), Feb. 20 (ANI): A study reveals that 35-40 percent of a child's 'Body Mass Index' - how fat or thin they are - is inherited from their parents.

Full Story >>

New Delhi [India], Feb 20. (ANI): Good news for all those lazy-headed not-really-a-cleanliness-freak out there! Scientists have found out that the obsession with hygiene could even be turning some beneficial bacteria found in the human gut into "endangered species".

Full Story >>

New Delhi [India], Feb 20. (ANI): In order to persuade someone to quit smoking, it is the 'emotions' that need to be triggered rather than inciting fear in an individual.

Full Story >>

No difference between good or bad diet: Study

Updated: Feb 20, 2017 05:54 IST

New Delhi [India], Feb 20. (ANI): Ever faced a choice between Brown and white bread?

Full Story >>

Washington D.C. [USA], Feb. 19 (ANI): To boost sustainability of livestock production, a study finds that gene editing - one of the newest and most promising tools of biotechnology - enables animal breeders to make beneficial genetic changes, without bringing along unwanted genetic changes.

Full Story >>

People with ADHD may have smaller brain volume

Updated: Feb 19, 2017 07:09 IST

New Delhi [India], Feb 19. (ANI): In a latest study it has been found out that people diagnosed with attention deficit hyperactivity disorder (ADHD) have smaller brain volume than those without the disorder.

Full Story >>

New Delhi [India], Feb 19. (ANI): What if we tell you that scientists can actually slow down the process of ageing. Sounds too good to be true right?

Full Story >>

New Delhi [India], Feb 19. (ANI): Lefty or righty? Well it was decided when you were still in your mum's womb!

Full Story >>

Dads-to be face greater risk of depression

Updated: Feb 19, 2017 06:53 IST

New Delhi [India], Feb 19. (ANI): Expecting a baby is always a joyous experience for both the mother and the father, however a latest study has found out that fathers-to-be can be at risk of depression symptoms if they feel stressed or are in poor health.

Full Story >>

New Delhi [India], Feb 19. (ANI): Do you find it difficult hearing out people at a noisy bar or a restaurant even though you have passed the hearing test with flying colors? Well, you might be secretly deaf!

Full Story >>

New Delhi [India], Feb 19. (ANI): What if we told you that rice has the potential of carrying arsenic and is more than hazardous to feed it to infants!

Full Story >>

Washington D.C. [USA], Feb. 18 (ANI): Now you can save your kid from surgery, as a study shows that antibiotics may be an effective treatment for acute non-complicated appendicitis in children, instead of surgery.

Full Story >>

Washington D.C. [USA], Feb. 18 (ANI): Attention new mommies, sing lullabies to your new born to feel more connected to your babies, suggests a study.

Full Story >>

Washington D.C. [USA], Feb. 18 (ANI): Cancer patients can improve their quality of life with just 30 minutes of walking, suggests a study.

Full Story >>

New Delhi [India], Feb. 17 (ANI): Birth of a baby may be a sweet moment but changing life style of women is posing 'sweet' challenge to it.

Full Story >>

New Delhi [India], Feb. 17 (ANI): Good news! A recent study shows that antibiotics may be an effective treatment for acute non-complicated appendicitis in children, instead of surgery.

Full Story >>

'Seagrass' can improve marine water quality

Updated: Feb 17, 2017 07:07 IST

Washington D.C. [USA], Feb. 17 (ANI): Underwater flowering plants and seagrass meadows known to produce natural antibiotics, can also improve the water quality of sea by suppressing pollution, reveals a study.

Full Story >>

Washington D.C. [USA], Feb. 17 (ANI): Before undergoing hip replacements, knee replacements or hernia repairs, do not let depression or anxiety take a toll on your health, as a study finds, a patients' mental health may affect their risk of experiencing wound-related complications after surgery.

Full Story >>

Washington D.C. [USA], Feb. 17 (ANI): Configure the airflow velocity of your Air Conditioner to a comfortable sleeping environment, as a study reveals when airflow is directed at a human body at an insensible velocity, it may increase your heart rate and affect sleeping positions.

Full Story >>