Tue, Jul 25, 2017 | updated 04:19 AM IST

Smell test can reveal if you are at Alzheimer's risk

Updated: Jul 27, 2016 09:53 IST      
Smell test can reveal if you are at Alzheimer's risk

Washington D.C, Jul 27 (ANI): An odour identification test can tell whether or not your loved one is at risk of Alzheimer's disease, suggests a recent study.

Two studies from Columbia University Medical Center (CUMC), New York State Psychiatric Institute and NewYork-Presbyterian suggested that the University of Pennsylvania Smell Identification Test (UPSIT) may offer a practical, low-cost alternative to other tests.

In one study, researchers administered UPSIT to 397 older adults (average age of 80 years) without dementia from a multiethnic population in northern Manhattan. Each of the participants also had an MRI scan to measure the thickness of the entorhinal cortex-the first area of the brain to be affected by Alzheimer's disease.

Four years later, 50 participants (12.6 percent) had developed dementia, and nearly 20 percent had signs of cognitive decline.

The researchers found that low UPSIT scores, but not entorhinal cortical thickness, were significantly associated with dementia and Alzheimer's disease. (Low UPSIT scores indicate decreased ability to correctly identify odors.)

Low UPSIT scores, but not entorhinal cortical thickness, also predicted cognitive decline, although entorhinal cortical thickness was significantly associated with UPSIT score in those who transitioned to dementia.

"Our research showed that odor identification impairment, and to a lesser degree, entorhinal cortical thickness, were predictors of the transition to dementia," said presenting author Seonjoo Lee. "These findings support odor identification as an early predictor, and suggest that impairment in odor identification may precede thinning in the entorhinal cortex in the early clinical stage of Alzheimer's disease."

In another study, researchers evaluated the usefulness of UPSIT and tests that measure the amount of amyloid in the brain (in higher amounts, the protein forms plaques in the brains of those with Alzheimer's disease) in predicting memory decline.

The researchers administered UPSIT and performed either beta amyloid PET scanning or analysis of cerebrospinal fluid in 84 older adults (median age of 71 years). Of these, 58 participants had mild cognitive impairment. The researchers followed the participants for at least six months.

At follow-up, 67 percent of the participants had signs of memory decline. Testing positive for amyloid with either method, but not UPSIT score, predicted cognitive decline. However, participants with a score of less than 35 were more than three times as likely to have memory decline as those with higher UPSIT scores.

"Our research suggests that both UPSIT score and amyloid status predict memory decline," said neurologist William Kreisl.

The study has been presented at Alzheimer's Association International Conference. (ANI)

World Optometry Congress to bring hope for visually impaired

Updated: Jul 24, 2017 14:40 IST     

New Delhi [India], July 24 (ANI): The world's visually impaired will be the subject of some serious discussion at the forthcoming second World Congress of Optometry in Hyderabad.

Full Story >>

Neuroticism might increase your life span

Updated: Jul 24, 2017 13:25 IST     

Washington D.C. [USA] ,July 24 (ANI): Neuroticism is one of the big five higher-order personality traits in the study of psychology.

Full Story >>

Washington D.C. [USA], July 24 (ANI): Survivors of a stroke or a mini-stroke without early complications have an increased risk of death, another stroke or heart attack (myocardial infarction) for at least five years following the initial stroke.

Full Story >>

Genetic variation may increase tuberculosis susceptibility

Updated: Jul 23, 2017 10:53 IST     

Washington D.C. [USA], July 23 (ANI): Chinese researchers have found that a single change in a gene may increase the risk of tuberculosis.

Full Story >>

This is your brain on depression

Updated: Jul 22, 2017 13:55 IST     

Washington D.C. [USA], July 22 (ANI): Got the blues? According to a recent study, depression can change the structure of your brain.

Full Story >>

Rush-hour pollution may be more harmful than thought

Updated: Jul 22, 2017 10:57 IST     

Washington D.C. [USA], Jul 22 (ANI): Turns out, rush-hour commuters may be in for a double whammy of pollution exposure.

Full Story >>

TRAC, MedGenome announce Cancer Immunotherapy solution

Updated: Jul 22, 2017 06:24 IST     

New Delhi [India], July 22 (ANI): Toronto Recombinant Antibody Centre (TRAC) from the University of Toronto, Canada agreed to license MedGenome's patented cancer immunotherapy solution OncoPept to develop biomarkers for their drug candidates against immune modulators to treat cancer.

Full Story >>

Are some people genetically programmed to be depressed?

Updated: Jul 21, 2017 09:48 IST     

Washington D.C. [USA], Jul 21 (ANI): It's a sombre thought, but it seems that some of us are born more likely to be depressed.

Full Story >>

Washington D.C. [USA], Jul 21 (ANI): A team of researchers has come up with a new imaging technique that can diagnose cardiac sarcoidosis much more accurately than traditional tests.

Full Story >>

Ahmedabad (Gujarat) [India], July 21 (ANI): Ayurveda is a form of alternative medicine which seeks to treat and integrate body, mind and spirit using a comprehensive holistic approach especially by emphasizing diet, herbal remedies, exercise, meditation, breathing, and physical therapy.

Full Story >>

Washington D.C. [USA], Jul 20 (ANI): When it comes to faring well after chemotherapy, a cancer patient's social interaction matters, according to a recent study.

Full Story >>

New radiotherapy find offers hope to cancer patients

Updated: Jul 20, 2017 10:06 IST     

Washington D.C. [USA], Jul 20 (ANI): An exciting discovery in the cancer treatment is having dramatic results.

Full Story >>

New strategy could yield more effective flu shots

Updated: Jul 20, 2017 09:46 IST     

Washington D.C. [USA], Jul 20 (ANI): A boosting skin vaccination with a biodegradable microneedle patch and protein constructed from sequences of influenza virus subtypes could improve the effectiveness of conventional influenza vaccines, according to a recent study.

Full Story >>

Revealed! Best time to sleep to wake up feeling refreshed

Updated: Jul 20, 2017 04:09 IST     

London [UK], July 20 (ANI): The secret of a good night's sleep has finally been unveiled!

Full Story >>

Anxiety drug may help you with fear of social rejection

Updated: Jul 19, 2017 14:22 IST     

Washington D.C. [USA], July 19 (ANI): A team of researchers has found that low doses of anxiety disorder-reducing drug can help highly-anxious people overcome their fear of being over-looked and rejected socially.

Full Story >>

Washington D.C. [USA], July 19 (ANI): Good news! A new technology may help to non-invasively predict children or newborn at risk of an asthma attack.

Full Story >>

Your poor sleep may increase risk of Alzheimer's: Study

Updated: Jul 19, 2017 10:08 IST     

Washington D.C. [USA], July 19 (ANI): Beware! Breathing problems during sleep may be a signal of an increased risk for Alzheimer's disease, warns a study.

Full Story >>

Indian population, carrier of hepatitis B: Study

Updated: Jul 18, 2017 20:01 IST     

New Delhi [India], July 18 (ANI): Viral hepatitis is inflammation and damage of the liver by viruses , most commonly hepatotrophic (predominantly with an affinity for attacking the liver - Hepatitis A , B , C , D , E ) or non hepatotrophic viruses (Generalized involvement of human body with liver as a target tissue seen with Dengue virus , Chikungunya etc.).

Full Story >>

This monsoon, let's be HepAware!

Updated: Jul 18, 2017 18:01 IST     

New Delhi [India], July 18 (ANI): Hepatitis A is mild to the moderate viral disorder of the liver which is affected by the consumption of contaminated food and water. Unfortunately, monsoons are the best time when air/water borne infections are at its peak.

Full Story >>

Washington D.C. [USA], July 18 (ANI): If your grandparents are suffering from dementia, then you can help them by interacting with them about their interests for an hour a week and improve their quality life.

Full Story >>