Fri, Apr 28, 2017 | updated 11:35 PM IST

Fighting inflammation, pain the 'green' way

Updated: Jul 28, 2016 15:05 IST      
Fighting inflammation, pain the 'green' way

Washington D.C, Jul 28 (ANI): A new research has found that two specific plant-derived compounds may be effective for fighting inflammation and pain.

Diterpenoids are found in certain plants, fungi, and marine organisms, and two in particular, carnosol (CS) and carnosic acid (CA), are known to interfere with multiple pathways in the human body associated with inflammation and pain.

A team led by Giuseppe Bifulco of the University of Salerno in Italy and Andreas Koeberle of the Friedrich Schiller University Jena in Germany, has investigated the effects of these natural products in their pure form in inflammatory pain through research involving human cells and mice.

The researchers found that the diterpenoids inhibited two enzymes involved in inflammation, fever, and pain. Overexpression of one of these enzymes has been observed in several inflammatory disorders as well as in many human tumors; the second enzyme is also a major player in inflammation and other immune-related processes in the body.

"We have demonstrated that 5-LO and mPGES-1, two key enzymes of inflammation, are primary targets of CS and CA, which are major bioactive ingredients of herbs that are used as spices, namely sage and rosemary, and in traditional medicine," said Bifulco.

Bifulco added, "Our study provides comprehensive insights into their anti-inflammatory mechanism. Understanding both the molecular basis and pharmacological relevance of natural products is essential to fully exploit the power of nature for human health."

The investigators noted that dual inhibitors of 5-LO and mPGES-1 are considered potential alternatives to classical anti-inflammatory and analgesic drugs that have well-documented side effects. Recently, the mPGES-1 inhibitor GRC 27864 (Glenmark Pharmaceuticals Ltd.) entered the first phase of clinical development.

"The discovery of new dual 5-LO/mPGES-1 inhibitors, like CS and CA, represents a valid strategy for the treatment of inflammatory and cancer diseases and further justifies the use of sage and rosemary in traditional medicine," said Koeberle.

He added, "It is important that these natural products are tested in different experimental inflammation and cancer animal models as well as in imaging studies to obtain a complete comprehension of the molecular basis behind their observed biological activity."

The findings are published in the British Journal of Pharmacology. (ANI)

New blood test may predict diabetes better

Updated: Apr 28, 2017 16:00 IST     

Washington D.C. [USA], Apr 28 (ANI): A team of researchers has come up with a new blood test that may better predict gestational diabetes.

Full Story >>

Turns out, e-cigarettes can help smokers kick the butt

Updated: Apr 28, 2017 14:11 IST     

Washington D.C. [USA], Apr 28 (ANI): Smokers rejoice! As a recent study suggests that your plan to kick the cigarette addiction by turning to the electronic version of butts won't go up in smoke.

Full Story >>

Affordable lab tests now at your doorstep

Updated: Apr 28, 2017 06:41 IST     

New Delhi [India], April 28 (ANI): Before going for any medical test, now compare the rates of different path-labs with just a click.

Full Story >>

Deal with depression in natural way

Updated: Apr 28, 2017 03:19 IST     

New Delhi [India], April 28 (ANI): Depression is world's leading illness and is one of the major reasons for suicides globally, says the World Health Organization (WHO). The story in India is no different.

Full Story >>

Parkinson's disease starts in gut: Study

Updated: Apr 27, 2017 10:03 IST     

Washington D.C. [USA], Apr 27 (ANI): A recent study suggests that parkinson's disease, a disorder of the central nervous system, may start in the gut and spread to the brain via the vagus nerve.

Full Story >>

Lung for Long: Gasp No More

Updated: Apr 26, 2017 18:45 IST     

New Delhi [India], Apr 26 (ANI-Businesswire India): Lungs in Delhi seem to be in dire straits. In the midst of ever thickening air pollution and lifestyle gone astray, lung power is ebbing fast. Data emerging from April 25 lung health camp organized in iconic Press Club of India (PCI) on the occasion of World Asthma Day pressed panic button as regards lung health of the capital city.

Full Story >>

Risk of obesity influenced by changes in our genes

Updated: Apr 26, 2017 15:22 IST     

New Delhi [India], Apr 26 (ANI): According to new study, a child's risk of obesity while growing up can be influenced by modifications to their DNA prior to birth.

Full Story >>

Patient with rare knee cancer undergoes life saving surgery

Updated: Apr 26, 2017 13:52 IST     

New Delhi [India], Apr 26 (ANI): A resident of Ganganager, in Rajasthan, was diagnosed of Large Soft Tissue Sarcoma (9Kg), with Neuro Vascular involvement.

Full Story >>

Here`s how protein impacts intellectual disability

Updated: Apr 26, 2017 07:36 IST     

Washington D.C. [USA], Apr 26 (ANI): A new study has paved the way for the potential treatments of intellectual disability and other neurodevelopmental disorders.

Full Story >>

Stem cells can help identify neuronal defects, suggests Study

Updated: Apr 25, 2017 12:26 IST     

Washington D.C. [USA], Apr 25 (ANI): According to a recent study, the researchers used stem cells derived from patients with Angelman syndrome to identify the underlying cellular defects that cause the rare neurogenetic disorder.

Full Story >>

#WorldMalariaDay: Effective steps to prevent Malaria

Updated: Apr 25, 2017 11:01 IST     

New Delhi [India], Apr 25 (ANI): The theme for World Malaria Day this year is "End Malaria for Good".

Full Story >>

Artificial Intelligence may help in diagnosing Tuberoculosis

Updated: Apr 25, 2017 11:01 IST     

Washington D.C. [USA], Apr 25 (ANI): If you are a patient of Tuberculosis, then we might have some good news for you.

Full Story >>

London [UK], Apr 25 (ANI): According to a new study, only one in five victims with serious injuries caused by child abuse in England and Wales gets treated at a major trauma centre.

Full Story >>

Gene reveals cause of fatal childhood disorder: Study

Updated: Apr 24, 2017 17:51 IST     

New Delhi [India], Apr 24 (ANI): A gene, involved in brain development, which can lead to severe disability and infant death, has been identified by scientists.

Full Story >>

Alcohol: the modern age liver killer

Updated: Apr 24, 2017 17:51 IST     

New Delhi [India], Apr 24 (ANI): Alcohol is predominantly metabolized through liver, hence its cumulative toxicity over years play important role in liver diseases or pancreatic diseases.

Full Story >>

Washington D.C. [USA], April 24 (ANI): Due to increasing deaths because of prostate cancer among men, US researchers have suggested a special screening more frequently and at an early age to avoid the development of preclinical prostate cancer - that is not symptomatic - to advanced stages.

Full Story >>

Love guzzling diet sodas? Here is why you should NOT

Updated: Apr 24, 2017 07:02 IST     

New York [U.S.], Apr. 24 (ANI): Still downing gallons of diet soda despite knowing that it wrecks your body? Maybe the knowledge of artificially sweetened beverages taking a toll on your brain as well ought to make an impact on your unhealthy habit.

Full Story >>

Washington D.C. [USA], Apr 23 (ANI): A recent study has demonstrated that in the general population, central obesity, insulin resistance, diabetes, lipid abnormalities and high alcohol consumption were the strongest predictors of severe liver disease.

Full Story >>

Breastmilk may help detect your cancer risk

Updated: Apr 23, 2017 11:50 IST     

Washington D.C. [USA], Apr 23 (ANI): Breastmilk might offer clues about a woman's cancer risk, according to a recent research.

Full Story >>

Soon, new weapon in war against obesity

Updated: Apr 23, 2017 11:14 IST     

Washington D.C. [USA], Apr 23 (ANI): A team of scientists has uncovered a potential approach to combat obesity.

Full Story >>