Sat, Jul 29, 2017 | updated 12:35 AM IST

Fighting inflammation, pain the 'green' way

Updated: Jul 28, 2016 15:05 IST      
Fighting inflammation, pain the 'green' way

Washington D.C, Jul 28 (ANI): A new research has found that two specific plant-derived compounds may be effective for fighting inflammation and pain.

Diterpenoids are found in certain plants, fungi, and marine organisms, and two in particular, carnosol (CS) and carnosic acid (CA), are known to interfere with multiple pathways in the human body associated with inflammation and pain.

A team led by Giuseppe Bifulco of the University of Salerno in Italy and Andreas Koeberle of the Friedrich Schiller University Jena in Germany, has investigated the effects of these natural products in their pure form in inflammatory pain through research involving human cells and mice.

The researchers found that the diterpenoids inhibited two enzymes involved in inflammation, fever, and pain. Overexpression of one of these enzymes has been observed in several inflammatory disorders as well as in many human tumors; the second enzyme is also a major player in inflammation and other immune-related processes in the body.

"We have demonstrated that 5-LO and mPGES-1, two key enzymes of inflammation, are primary targets of CS and CA, which are major bioactive ingredients of herbs that are used as spices, namely sage and rosemary, and in traditional medicine," said Bifulco.

Bifulco added, "Our study provides comprehensive insights into their anti-inflammatory mechanism. Understanding both the molecular basis and pharmacological relevance of natural products is essential to fully exploit the power of nature for human health."

The investigators noted that dual inhibitors of 5-LO and mPGES-1 are considered potential alternatives to classical anti-inflammatory and analgesic drugs that have well-documented side effects. Recently, the mPGES-1 inhibitor GRC 27864 (Glenmark Pharmaceuticals Ltd.) entered the first phase of clinical development.

"The discovery of new dual 5-LO/mPGES-1 inhibitors, like CS and CA, represents a valid strategy for the treatment of inflammatory and cancer diseases and further justifies the use of sage and rosemary in traditional medicine," said Koeberle.

He added, "It is important that these natural products are tested in different experimental inflammation and cancer animal models as well as in imaging studies to obtain a complete comprehension of the molecular basis behind their observed biological activity."

The findings are published in the British Journal of Pharmacology. (ANI)

New Delhi [India], July 28 (ANI): An analysis done by SRL Diagnostics, a diagnostic chain in India, on Viral Hepatitis (A, B, C, E) testing done in its laboratories revealed that Hepatitis C Virus infection was most common in the Northern states of India when compared with other parts of the country.

Full Story >>

New Delhi [India], July 28 (ANI): As per recent statistics, about 400 million people around the world are living with Hepatitis B or C. Of these, 52 million are in India alone. Hepatitis causes inflammation of the liver, further leading to serious scarring (cirrhosis), which can prove fatal in the long run.

Full Story >>

In death, 25-year-old gifts life to four!

Updated: Jul 27, 2017 18:49 IST     

New Delhi, Thursday, 27 July 2017: At a time, when traffic in South Delhi crawls at a snail's pace and most dread to get stuck on their way back home from work, the clockwork precision of Delhi Police helped transport a beating heart between Fortis Vasant Kunj and Fortis Escorts to save a life.

Full Story >>

Now, alternative pain relief for knee replacement patients

Updated: Jul 27, 2017 13:42 IST     

Washington D.C. [USA], Jul 27 (ANI): There's new hope in the battle against pain as a recent study has recommended an alternative method of relief for patients undergoing knee replacement surgery.

Full Story >>

This stitch in time can save stroke patients' lives

Updated: Jul 27, 2017 11:32 IST     

Washington D.C. [USA], Jul 27 (ANI): A recent study has offered hope to the stroke patients, promising new options and a wider treatment window.

Full Story >>

Rural households at lower risk of inflammatory bowel disease

Updated: Jul 26, 2017 16:33 IST     

Washington D.C. [USA], July 26 (ANI): People, particularly for young children and adolescents, who live in rural areas are at decreased risk of developing inflammatory bowel disease (IBD), according to a new study.

Full Story >>

23% Indian women seek dignity, respect in maternal healthcare

Updated: Jul 26, 2017 12:35 IST     

New Delhi [India], July 26 (ANI): In its campaign to understand the women's want for improved maternal health in India, White Ribbon Alliance India steered the nation-wide campaign 'Hamara Swasthya, Hamari Awaz'.

Full Story >>

New Delhi [India], July 26 (ANI): A 45 year old patient undergoes successful liver transplant at BLK Super Speciality Hospital, after receiving liver from a donor after his cardiac death - what is called as 'Donation After Cardiac Death' or DCD.

Full Story >>

India carries out more than 100 bariatric surgeries a day

Updated: Jul 26, 2017 04:35 IST     

New Delhi [India], July 26 (ANI): India is carrying out more than 100 weight loss surgeries a day.

Full Story >>

Washington D.C. [USA], July 25 (ANI): A study has recently suggested that children, who experience sleep disruptions following violent incidents in neighborhoods, struggle more to learn and perform academic tasks at school.

Full Story >>

World Embryologists Day: Myths and facts about IVF

Updated: Jul 25, 2017 14:34 IST     

New Delhi [India], July 25 (ANI): The birth of a child is a happy occasion for any family and a new chapter in the life of a couple. However, today, there is an increase in the number of couples who are unable to conceive due to many reasons.

Full Story >>

World IVF Day: Celebrating birth of world's first IVF baby

Updated: Jul 25, 2017 12:03 IST     

Gurugram (Haryana) [India], July 25 (ANI): Thirty-nine years ago the world was introduced to its first test-tube baby when Louise Brown was born through the IVF technique at Bourn Hall.

Full Story >>

Washington D.C. [USA], July 25 (ANI): To provide better shield against infection, researchers have devised a new way of producing the seasonal flu vaccine.

Full Story >>

Can eye test help diagnose autism?

Updated: Jul 25, 2017 10:27 IST     

Washington D.C. [USA], July 25 (ANI): Researchers have herald a new tool that helps physicians identify a sub-group of people with Autism spectrum disorders (ASD).

Full Story >>

New Delhi [India], 25 July (ANI): Infertility is on the rise among Indians with 10 to 14% of the population affected by it. The main addition has been the group of career-oriented women who delay childbearing and try for a baby later as compared to women in previous generations.

Full Story >>

Ensure to have healthy heartbeats

Updated: Jul 25, 2017 04:33 IST     

New Delhi [India], July 25 (ANI): With increasing lifestyle problems, Cardiovascular Diseases (CVDs) have emerged as a leading cause of mortality worldwide, followed by cancer.

Full Story >>

World Optometry Congress to bring hope for visually impaired

Updated: Jul 24, 2017 14:40 IST     

New Delhi [India], July 24 (ANI): The world's visually impaired will be the subject of some serious discussion at the forthcoming second World Congress of Optometry in Hyderabad.

Full Story >>

Neuroticism might increase your life span

Updated: Jul 24, 2017 13:25 IST     

Washington D.C. [USA] ,July 24 (ANI): Neuroticism is one of the big five higher-order personality traits in the study of psychology.

Full Story >>

Washington D.C. [USA], July 24 (ANI): Survivors of a stroke or a mini-stroke without early complications have an increased risk of death, another stroke or heart attack (myocardial infarction) for at least five years following the initial stroke.

Full Story >>

Genetic variation may increase tuberculosis susceptibility

Updated: Jul 23, 2017 10:53 IST     

Washington D.C. [USA], July 23 (ANI): Chinese researchers have found that a single change in a gene may increase the risk of tuberculosis.

Full Story >>