Sat, Feb 25, 2017 | updated 11:34 PM IST

TB tricks one's immune system to spread it among others

Updated: Oct 21, 2016 09:09 IST

Washington D.C. [USA], Oct. 21 (ANI): A new study suggests that tuberculosis (TB) tricks the immune system into attacking the body's lung tissue so that the bacteria are allowed to spread to other people.

The concept, as per the University of Southampton research, proposes that current ideas about how tuberculosis develops in patients may be incomplete and that, in fact, infection causes autoimmunity, where the immune system reacts incorrectly to its own tissue.

Tuberculosis kills more people than any other infectious disease, and the causative bacterium, Mycobacterium tuberculosis, is becoming increasingly resistant to antibiotics used to treat the infection.

The Southampton research team conducted a review of published studies and found evidence suggesting that an autoimmunity process develops in TB.

Paul Elkington, who led the project, said, "We are not disputing that the immune system mainly targets the bacteria to fight it off, but we are suggesting that there is more to the story."

"It seems that TB tricks the immune system into damaging our own lung tissue, which therefore makes the person highly infectious through coughing and the TB then spreads by aerosol droplets to other individuals," he said, adding, "There is also a group of patients who develop a range of symptoms, such as eye inflammation, joint inflammation and skin rashes, that are not explained by current TB disease concepts. These symptoms are usually associated with diseases like rheumatoid arthritis and Crohn's disease, which led us to believe autoimmunity plays a key role in the TB disease process."

The researcher highlights that more research is needed to investigate the hypothesis, but if it is proved, the discovery could have major implications for the design of new vaccines and drug treatments.

The Southampton team is now undertaking a programme of work to investigate this new concept. Their approach is to combine the study of cells isolated from TB-infected patients with micro-engineering in 3D in the laboratory to investigate how TB damages the lungs.

The study has been published in Trends in Immunology. (ANI)

Guwahati (Assam) [India], Feb.25 (ANI): Union Health Minister J.P. Nadda recently inaugurated the first-ever cashless cancer hospital at the Guwahati Medical College here in presence of Assam Health Minister Himanta Biswa Sharma and Chief Minister Sarbananda Sonowal.

Full Story >>

Berlin (Germany), Feb 25 (ANI): People experiencing anxiety disorders, we have got some bad news for you.

Full Story >>

Dietary prebiotics improve sleep: Study

Updated: Feb 25, 2017 07:20 IST

Washington D.C. [USA], Feb. 25 (ANI): Health benefits of probiotics- the "good bacteria" found in fermented foods and dietary supplements- is known to almost all.

Full Story >>

Too much sugar may causes Alzheimer's

Updated: Feb 24, 2017 06:13 IST

London [UK], Feb. 24 (ANI): A diet, high in sugar, could lead to Alzheimers, as a study finds a link between sugar and the brain disease.

Full Story >>

New Delhi [India], Feb. 23 (ANI): A study was conducted in 19 centers over a period of six months to understand the different types of constipation and the causes behind them. One of the key highlights has been that constipation is highly prevalent in cities as compared to the rural areas.

Full Story >>

New Delhi [India], Feb 23. (ANI): Never neglect your kid, if you do not want to subject him to mental health issues!

Full Story >>

Now, you can cure insomnia with placebo: Study

Updated: Feb 23, 2017 06:27 IST

Washington D.C. [USA], Feb. 23 (ANI): Briton researchers have found a simple placebo may really work well to cure insomnia.

Full Story >>

Washington D.C. [USA], Feb. 23 (ANI): Beware! US researchers warned that taking drugs to reduce gastric acid for prolonged periods may lead to serious kidney problems, including kidney failure.

Full Story >>

New Delhi [India], Feb. 22 (ANI): In rarest of its kind, a paediatric surgery performed by doctors at a city-based hospital gave a new lease of life to a newborn, suffering from a life-threatening defect of the alimentary canal.

Full Story >>

Beware! Zika can be a reason for miscarriage

Updated: Feb 22, 2017 14:18 IST

Washington D.C. (USA), Feb. 22 (ANI): Beware to-be mothers! According to a recent study, Zika virus could lead to a greater risk of miscarriage in the early stage of pregnancy.

Full Story >>

Washington D.C. (USA), Feb. 22 (ANI): Women with a rare type of epithelial ovarian or peritoneum cancer, can now take sigh of relief.

Full Story >>

Washington D.C. [USA], Feb. 22 (ANI): Now don't blame those chips and chocolates for you childs extra pounds, as a study says around 35-40 percent of a child's is inherited from their parents.

Full Story >>

Drinking too much may age arteries over time!

Updated: Feb 22, 2017 06:03 IST

Washington D.C. [USA], Feb. 22 (ANI): Excessive boozing over the years might age arteries prematurely, especially in men, putting them at an increased risk for heart disease.

Full Story >>

Chronic knee pain may be treated online

Updated: Feb 21, 2017 06:41 IST

Washington D.C. [USA], Feb. 21 (ANI): A study has found out that an online intervention, combining home exercise and pain-coping skills training, provided substantial clinical benefits for patients suffering from chronic knee pain.

Full Story >>

Washington D.C. [USA], Feb. 21 (ANI): Only exercise is not enough to maintain that figure, which is an after effect of much toil and sweat!

Full Story >>

New Delhi [India], Feb. 20 (ANI): With rising life expectancy, increasingly sedentary lifestyles and surge in incidence of obesity, India is also witnessing a resultant rise in orthopedic problems as a natural corollary.

Full Story >>

Children inherit obesity from parents: Study

Updated: Feb 20, 2017 14:54 IST

Washington D.C. (USA), Feb. 20 (ANI): A study reveals that 35-40 percent of a child's 'Body Mass Index' - how fat or thin they are - is inherited from their parents.

Full Story >>

New Delhi [India], Feb 20. (ANI): Good news for all those lazy-headed not-really-a-cleanliness-freak out there! Scientists have found out that the obsession with hygiene could even be turning some beneficial bacteria found in the human gut into "endangered species".

Full Story >>

New Delhi [India], Feb 20. (ANI): In order to persuade someone to quit smoking, it is the 'emotions' that need to be triggered rather than inciting fear in an individual.

Full Story >>

No difference between good or bad diet: Study

Updated: Feb 20, 2017 05:54 IST

New Delhi [India], Feb 20. (ANI): Ever faced a choice between Brown and white bread?

Full Story >>