Sat, Apr 29, 2017 | updated 09:00 PM IST

Scientists identify potent antibody that neutralizes HIV strains

Updated: Nov 16, 2016 13:05 IST      
Scientists identify potent antibody that neutralizes HIV strains

Washington D.C. [USA], Nov. 16 (ANI): An antibody from an HIV-infected person can potently neutralized 98 percent of HIV isolates nearly all HIV strains, discovered scientists from the National Institutes of Health.

The remarkable breadth and potency of this antibody, named N6, make it an attractive candidate for further development to potentially treat or prevent HIV infection, say the researchers.

The scientists, led by Mark Connors, M.D., of NIH's National Institute of Allergy and Infectious Diseases (NIAID), also tracked the evolution of N6 over time to understand how it developed the ability to potently neutralize nearly all HIV strains. This information will help inform the design of vaccines to elicit such broadly neutralizing antibodies.

Identifying broadly neutralizing antibodies against HIV has been difficult because the virus rapidly changes its surface proteins to evade recognition by the immune system. In 2010, scientists at NIAID's Vaccine Research Center (VRC) discovered an antibody called VRC01 that can stop up to 90 percent of HIV strains from infecting human cells. Like VRC01, N6 blocks infection by binding to a part of the HIV envelope called the CD4 binding site, preventing the virus from attaching itself to immune cells.

Findings from the current study showed that N6 evolved a unique mode of binding that depends less on a variable area of the HIV envelope known as the V5 region and focuses more on conserved regions, which change relatively little among HIV strains. This allows N6 to tolerate changes in the HIV envelope, including the attachment of sugars in the V5 region, a major mechanism by which HIV develops resistance to other VRC01-class antibodies.

The new findings suggest that N6 could pose advantages over VRC01, which currently is being assessed as intravenous infusions in clinical trials to see if it can safely prevent HIV infection in humans. Due to its potency, N6 may offer stronger and more durable prevention and treatment benefits, and researchers may be able to administer it subcutaneously (into the fat under the skin) rather than intravenously. In addition, its ability to neutralize nearly all HIV strains would be advantageous for both prevention and treatment strategies. (ANI)

Online support can help people with bipolar disorder

Updated: Apr 29, 2017 14:43 IST     

Washington D.C. [USA], April 29 (ANI): Briton researchers have developed a cheap and accessible online relapse prevention tool for people, who seek support following treatment of Bipolar Disorder.

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Ailing from chronic inflammation? Here is why

Updated: Apr 29, 2017 09:05 IST     

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Bullying can lead to desire for 'cosmetic surgery' in teens

Updated: Apr 29, 2017 08:47 IST     

Washington D.C. [USA], Apr 29 (ANI): According to a new study, young adults who are involved in bullying, whether victims or perpetrators, are more likely to express the desire for cosmetic surgery in order to become more attractive.

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New blood test may predict diabetes better

Updated: Apr 28, 2017 16:00 IST     

Washington D.C. [USA], Apr 28 (ANI): A team of researchers has come up with a new blood test that may better predict gestational diabetes.

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Turns out, e-cigarettes can help smokers kick the butt

Updated: Apr 28, 2017 14:11 IST     

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Affordable lab tests now at your doorstep

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Deal with depression in natural way

Updated: Apr 28, 2017 03:19 IST     

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Parkinson's disease starts in gut: Study

Updated: Apr 27, 2017 10:03 IST     

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Lung for Long: Gasp No More

Updated: Apr 26, 2017 18:45 IST     

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Risk of obesity influenced by changes in our genes

Updated: Apr 26, 2017 15:22 IST     

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Patient with rare knee cancer undergoes life saving surgery

Updated: Apr 26, 2017 13:52 IST     

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Here`s how protein impacts intellectual disability

Updated: Apr 26, 2017 07:36 IST     

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Stem cells can help identify neuronal defects, suggests Study

Updated: Apr 25, 2017 12:26 IST     

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#WorldMalariaDay: Effective steps to prevent Malaria

Updated: Apr 25, 2017 11:01 IST     

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Artificial Intelligence may help in diagnosing Tuberoculosis

Updated: Apr 25, 2017 11:01 IST     

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Gene reveals cause of fatal childhood disorder: Study

Updated: Apr 24, 2017 17:51 IST     

New Delhi [India], Apr 24 (ANI): A gene, involved in brain development, which can lead to severe disability and infant death, has been identified by scientists.

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Alcohol: the modern age liver killer

Updated: Apr 24, 2017 17:51 IST     

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Washington D.C. [USA], April 24 (ANI): Due to increasing deaths because of prostate cancer among men, US researchers have suggested a special screening more frequently and at an early age to avoid the development of preclinical prostate cancer - that is not symptomatic - to advanced stages.

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Love guzzling diet sodas? Here is why you should NOT

Updated: Apr 24, 2017 07:02 IST     

New York [U.S.], Apr. 24 (ANI): Still downing gallons of diet soda despite knowing that it wrecks your body? Maybe the knowledge of artificially sweetened beverages taking a toll on your brain as well ought to make an impact on your unhealthy habit.

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