Wed, Feb 22, 2017 | updated 03:06 AM IST

Putrid camel pee could aid people with sleeping sickness: Study

Updated: Nov 18, 2016 16:19 IST

Washington D.C. [USA], Nov. 18 (ANI): According to a research published in the Proceedings of the National Academy of Science, Biochemists have solved an old mystery as to the cause of especially smelly camel urine, with implications for the millions of people affected by African parasites called trypanosomes.

These parasites frequently cause fatalities via sleeping sickness.

The biochemists have unearthed a metabolic by-product of trypanosome activity known as indolepyruvate, which may offer excellent possibilities for developing anti-trypanosome drugs and therapies because inhibiting its production may be key in fighting the parasite.

Additionally, because this by-product modifies the behaviour of important immune cells and prevents them from becoming fully active, it has potential as an inhibitor of common inflammatory diseases.

Trypanosomes are parasites of the mammalian bloodstream that rely on biting flies - like the tsetse fly -- for transmission.

They must constantly evade their hosts' immune defences through waves of infections, while simultaneously prolonging the survival of their hosts, so as to ensure life-cycle completion and future transmission via other biting flies.

Neither vaccination nor prophylactic intervention is possible, and all current treatments have associated limitations that restrict their application.

Although cases of human infection have declined recently these parasites still represent a major societal burden across 36 sub-Saharan countries that are within range of the tsetse fly vector.

Nolan said: "Camel herders have long known that the urine of camels infected with trypanosomes has a pungent odour, and is reddish brown in colour. We found that this is directly attributable to parasite breakdown of aromatic amino acids, such as tryptophan, in the host, and to the excretion of the novel by-products into the bloodstream."

"The advantage for the parasite of excreting indolepyruvate is that it modulates the inflammatory and immune responses of the host -- especially at the peaks of infection. This prolongs host survival and thereby potentiates the transmission of the parasite to the tsetse fly, which ensures it can complete its life cycle," he added.

Concluding, "We are hopeful that by solving the riddle of the putrid camel pee, these new insights have unearthed a potential target for anti-trypanosome therapies, which are badly needed as sleeping sickness continues to claim a huge number of lives in sub-Saharan Africa." (ANI)

Chronic knee pain may be treated online

Updated: Feb 21, 2017 06:41 IST

Washington D.C. [USA], Feb. 21 (ANI): A study has found out that an online intervention, combining home exercise and pain-coping skills training, provided substantial clinical benefits for patients suffering from chronic knee pain.

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Washington D.C. [USA], Feb. 21 (ANI): Only exercise is not enough to maintain that figure, which is an after effect of much toil and sweat!

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New Delhi [India], Feb. 20 (ANI): With rising life expectancy, increasingly sedentary lifestyles and surge in incidence of obesity, India is also witnessing a resultant rise in orthopedic problems as a natural corollary.

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Children inherit obesity from parents: Study

Updated: Feb 20, 2017 14:54 IST

Washington D.C. (USA), Feb. 20 (ANI): A study reveals that 35-40 percent of a child's 'Body Mass Index' - how fat or thin they are - is inherited from their parents.

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New Delhi [India], Feb 20. (ANI): Good news for all those lazy-headed not-really-a-cleanliness-freak out there! Scientists have found out that the obsession with hygiene could even be turning some beneficial bacteria found in the human gut into "endangered species".

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New Delhi [India], Feb 20. (ANI): In order to persuade someone to quit smoking, it is the 'emotions' that need to be triggered rather than inciting fear in an individual.

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No difference between good or bad diet: Study

Updated: Feb 20, 2017 05:54 IST

New Delhi [India], Feb 20. (ANI): Ever faced a choice between Brown and white bread?

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Washington D.C. [USA], Feb. 19 (ANI): To boost sustainability of livestock production, a study finds that gene editing - one of the newest and most promising tools of biotechnology - enables animal breeders to make beneficial genetic changes, without bringing along unwanted genetic changes.

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People with ADHD may have smaller brain volume

Updated: Feb 19, 2017 07:09 IST

New Delhi [India], Feb 19. (ANI): In a latest study it has been found out that people diagnosed with attention deficit hyperactivity disorder (ADHD) have smaller brain volume than those without the disorder.

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New Delhi [India], Feb 19. (ANI): What if we tell you that scientists can actually slow down the process of ageing. Sounds too good to be true right?

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New Delhi [India], Feb 19. (ANI): Lefty or righty? Well it was decided when you were still in your mum's womb!

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Dads-to be face greater risk of depression

Updated: Feb 19, 2017 06:53 IST

New Delhi [India], Feb 19. (ANI): Expecting a baby is always a joyous experience for both the mother and the father, however a latest study has found out that fathers-to-be can be at risk of depression symptoms if they feel stressed or are in poor health.

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New Delhi [India], Feb 19. (ANI): Do you find it difficult hearing out people at a noisy bar or a restaurant even though you have passed the hearing test with flying colors? Well, you might be secretly deaf!

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New Delhi [India], Feb 19. (ANI): What if we told you that rice has the potential of carrying arsenic and is more than hazardous to feed it to infants!

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Washington D.C. [USA], Feb. 18 (ANI): Now you can save your kid from surgery, as a study shows that antibiotics may be an effective treatment for acute non-complicated appendicitis in children, instead of surgery.

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Washington D.C. [USA], Feb. 18 (ANI): Attention new mommies, sing lullabies to your new born to feel more connected to your babies, suggests a study.

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Washington D.C. [USA], Feb. 18 (ANI): Cancer patients can improve their quality of life with just 30 minutes of walking, suggests a study.

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New Delhi [India], Feb. 17 (ANI): Birth of a baby may be a sweet moment but changing life style of women is posing 'sweet' challenge to it.

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New Delhi [India], Feb. 17 (ANI): Good news! A recent study shows that antibiotics may be an effective treatment for acute non-complicated appendicitis in children, instead of surgery.

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'Seagrass' can improve marine water quality

Updated: Feb 17, 2017 07:07 IST

Washington D.C. [USA], Feb. 17 (ANI): Underwater flowering plants and seagrass meadows known to produce natural antibiotics, can also improve the water quality of sea by suppressing pollution, reveals a study.

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