Mon, Mar 27, 2017 | updated 08:09 PM IST

In path breaking discovery, scientists develop vaccine against opioid overdose

Updated: Nov 26, 2016 13:55 IST

Washington D.C [US], Nov.26 (ANI): According to a recent study, scientists have developed a vaccine that blocks the pain-numbing effects of the opioid drugs oxycodone (oxy) and hydrocodone (hydro) in animal models.

Published in the journal ACS Chemical Biology, the vaccine also appears to decrease the risk of fatal opioid overdose, a growing cause of death in the United States.

"We saw both blunting of the drug's effects and, remarkably, prevention of drug lethality," said researcher Kim D. Janda.

Adding, "The protection against overdose death was unforeseen but clearly of enormous potential clinical benefit."

The new oxy/hydro vaccine takes advantage of the immune system's ability to recognize, seek out and neutralize invaders.

Opioids were designed to reach receptors in the brain, causing pain reduction and feelings of euphoria.

For their vaccine, the researchers combined a signature opioid structure with a molecule to trigger an immune response. When injected, the vaccine teaches the immune system to bind to the drug molecule and remove it from circulation.

The vaccine-derived antibodies were tailored by TSRI scientists to seek out the prescription drug and block the opioid from reaching the brain, potentially depriving a person of the "reward" of consuming the drug.

The scientists believe a vaccine approach could have an advantage over current opioid addiction therapies because it would not alter brain chemistry like many of today's anti-addiction therapies do.

"The vaccine approach stops the drug before it even gets to the brain," said study co-author Cody J. Wenthur, adding it's like a preemptive strike.

The researchers found that their vaccine design blocked pain

perception of oxy/hydro use in mice.

Indeed, those given the vaccine did not display the usual symptoms of a drug high such as ignoring pain and discomfort.

In further tests, the rodents also appeared less susceptible to fatal overdose.

Although it was found that some vaccinated mice did succumb to the opioid drug's toxic effects, the researchers noted that it took much longer for the drug to impart its toxicity.

If this effect holds true in humans, the vaccine could extend the window of time for clinical assistance if overdose occurs.

The scientists also discovered that the vaccine remained effective in mice for the entire 60-day study period, and they believe it has the potential to last even longer.

This oxy/hydro vaccine is not the first ever tested, but it is the first to use a faithful representation of the opioid in its design, which prompts the remarkable efficacy seen with the TSRI vaccine.

"Our goal was to create a vaccine that mirrored the drug's natural structure. Clearly this tactic provided a broadly useful opioid deterrent," said study first author Atsushi Kimishima.(ANI)

Washington D.C. [USA], Mar. 26 (ANI): Attention dog lovers! With just six months of training, a German Shepherd can accurately detect breast cancer, a study finds.

Full Story >>

Washington D.C. [USA], Mar. 26 (ANI): A recent study has found that a sleepless night impairs your ability to interpret subtle expressions of happiness and sadness.

Full Story >>

Washington D.C. [USA], Mar. 26 (ANI): When it comes to new moms' workout programs, less is more and so, according to a Kansas State University researcher, new moms may need a bit more flexibility and support to ease back into exercise after giving birth.

Full Story >>

New approach to diagnosing mental disorders

Updated: Mar 26, 2017 10:48 IST

Washington D.C. [USA], Mar. 26 (ANI): A consortium of psychiatrists and psychologists has proposed a new approach to diagnosing mental disorders.

Full Story >>

Washington D.C. [USA], Mar. 26 (ANI): Boosting natural brain opioids may be a better way to treat anxiety, according to a recent study.

Full Story >>

Fecal transplant offers hope for autistic kids

Updated: Mar 26, 2017 09:37 IST

Washington D.C. [USA], Mar. 26 (ANI): In this new era of medical therapy dawning, fecal transplants are poised to help fight a range of conditions, from deadly superbugs to obesity and now, autism is in the firing line.

Full Story >>

Thiruvallur (Chennai) [India], Mar. 25 (ANI): A highly contagious viral disease of cattle and swine, Foot-and-Mouth Disease (FMD) has affected Karani village on the outskirts of Tamil Nadu's Tiruvallur district.

Full Story >>

New Delhi [India], Mar. 25 (ANI): The findings of the National Family Health Survey 2015-16 confirm what we all knew from clinical evidence - that hypertension has become a major health concern among the Indian population, with as many as 22% Indians hypertensive.

Full Story >>

Washington D.C. [USA], Mar. 25 (ANI): A prescription weight-loss medication can decrease the urge to use opiates such as oxycodone, according to a recent study.

Full Story >>

Washington D.C. [USA], Mar. 25 (ANI): A team of researchers has discovered a new gene that is associated with Tau accumulation, which is one of the defining features of Alzheimer disease (AD).

Full Story >>

Washington D.C. [USA], Mar. 25 (ANI): All it takes is the flip of a protein "switch" within the tiny wire-like capillaries of the brain to increase the blood flow that ensures optimal brain function.

Full Story >>

Washington D.C. [USA], Mar. 25 (ANI): Scientists have found that stem cell therapy repairs damaged lungs - raising hopes of a cure for the crippling chronic obstructive pulmonary disease (COPD) and cystic fibrosis.

Full Story >>

New method can cut dental implant failure

Updated: Mar 25, 2017 09:34 IST

Washington D.C. [USA], Mar. 25 (ANI): A team of researchers has come up with a new method to reduce dental implant failure.

Full Story >>

Washington D.C. [USA], Mar. 25 (ANI): A team of researchers has come up with a fluorogenic probe that can detect the activity of multidrug-resistant pathogens in an assay system.

Full Story >>

Virus hydrophobicity can help purify vaccines

Updated: Mar 25, 2017 07:46 IST

Washington D.C. [USA], Mar. 25 (ANI): A team of researchers has found that hydrophobic proteins on virus surfaces can help purify vaccines.

Full Story >>

Washington D.C. [USA], Mar. 25 (ANI): A team of researchers has shed light on why survivors of childhood brain tumours may be prone to heart disease, stroke, type 2 diabetes and early death.

Full Story >>

New Delhi [India], Mar. 24 (ANI): Continuing its efforts to raise awareness on tuberculosis and its diagnosis, Division of Clinical Microbiology & Molecular Medicine Department of Laboratory Medicine, AIIMS, and BD (Becton Dickinson India) for the third consecutive year organized a symposium today on "challenges in diagnosis and eradication of tuberculosis".

Full Story >>

New Delhi [India], Mar. 24 (ANI): On the solemn occasion of World Tuberculosis (TB) Day, Members of Parliament, policymakers, TB patients, survivors, and citizens of the civil society gathered at India Gate on Thursday, March 23 to pay tribute to the nearly five lakh lives lost due to this disease last year.

Full Story >>

New Delhi [India], Mar. 24 (ANI): Emergence of multi drug resistant TB and complications aggravated by high rates of co-infection with HIV-AIDS has renewed the threat of TB epidemic in India. With widespread prevalence of the infection, children experience a serious risk of contracting Tuberculosis, especially if they are under-nourished.

Full Story >>

New Delhi [India], Mar. 24 (ANI): Tuberculosis can affect any age, caste or class and it is one of the top 10 causes of death across the globe, ranking above HIV and malaria.

Full Story >>