Wed, Apr 26, 2017 | updated 05:20 PM IST

Gluten-free diet in Celiac disease may still lead to intestinal damage: Study

Updated: Dec 01, 2016 11:46 IST      
Gluten-free diet in Celiac disease may still lead to intestinal damage: Study

Washington DC [US], Dec. 1 (ANI): Even after strict adherence to a gluten-free diet, nearly one in five kids with celiac disease sustain persistent intestinal damage, reports a study.

The article has been published in the journal of Pediatric Gastroenterology and Nutrition.

Findings were also consistent in adults, which showed that more than 33 percent of adult patients on a gluten-free diet have persistent intestinal damage, despite a reduction of symptoms or the results of blood tests.

"The number of children who don't heal on the gluten-free diet was much higher than expected," said Alessio Fasano, co-senior author of the study.

"We assumed that healing would occur once a patient was put on the gluten-free diet. Now that we have learned that this is not the case for all celiac patients, we are changing our clinical practice by repeating the endoscopy after one year of the implementation of the gluten-free diet," Fasano explained.

The study was based on a retrospective examination of the biopsy and medical records of 103 children with celiac disease treated at MassGeneral Hospital for Children (MGHfC) and Boston Children's Hospital (BCH) in New York.

Most pediatric patients were over the age of 10 and were monitored for mucosal healing with a repeat endoscopy, along with follow-up blood testing, after one year of treatment with the gluten-free diet.

The children were on gluten-free diet for one year and were determined by dietitians and other hospital health care practitioners to have complied well with the diet.

The biopsies found the persistent intestinal damage in 19 percent of the children.

Another finding that surprised Fasano was that blood levels of the autoantibody IgA tTG - the primary lab test used to monitor celiac disease - did not accurately measure mucosal recovery.

"Malabsorption (imperfect absorption of food material by the small intestine) and inflammation in children may have negative repercussions on physical and cognitive development," the authors noted.

Although the long-term risks for children with persistent intestinal damage are not clear, such damage in adults has been linked to an increased risk of lymphoma, low bone density and fracture. (ANI)

Risk of obesity influenced by changes in our genes

Updated: Apr 26, 2017 15:22 IST     

New Delhi [India], Apr 26 (ANI): According to new study, a child's risk of obesity while growing up can be influenced by modifications to their DNA prior to birth.

Full Story >>

Patient with rare knee cancer undergoes life saving surgery

Updated: Apr 26, 2017 13:52 IST     

New Delhi [India], Apr 26 (ANI): A resident of Ganganager, in Rajasthan, was diagnosed of Large Soft Tissue Sarcoma (9Kg), with Neuro Vascular involvement.

Full Story >>

Here`s how protein impacts intellectual disability

Updated: Apr 26, 2017 07:36 IST     

Washington D.C. [USA], Apr 26 (ANI): A new study has paved the way for the potential treatments of intellectual disability and other neurodevelopmental disorders.

Full Story >>

Stem cells can help identify neuronal defects, suggests Study

Updated: Apr 25, 2017 12:26 IST     

Washington D.C. [USA], Apr 25 (ANI): According to a recent study, the researchers used stem cells derived from patients with Angelman syndrome to identify the underlying cellular defects that cause the rare neurogenetic disorder.

Full Story >>

#WorldMalariaDay: Effective steps to prevent Malaria

Updated: Apr 25, 2017 11:01 IST     

New Delhi [India], Apr 25 (ANI): The theme for World Malaria Day this year is "End Malaria for Good".

Full Story >>

Artificial Intelligence may help in diagnosing Tuberoculosis

Updated: Apr 25, 2017 11:01 IST     

Washington D.C. [USA], Apr 25 (ANI): If you are a patient of Tuberculosis, then we might have some good news for you.

Full Story >>

London [UK], Apr 25 (ANI): According to a new study, only one in five victims with serious injuries caused by child abuse in England and Wales gets treated at a major trauma centre.

Full Story >>

Gene reveals cause of fatal childhood disorder: Study

Updated: Apr 24, 2017 17:51 IST     

New Delhi [India], Apr 24 (ANI): A gene, involved in brain development, which can lead to severe disability and infant death, has been identified by scientists.

Full Story >>

Alcohol: the modern age liver killer

Updated: Apr 24, 2017 17:51 IST     

New Delhi [India], Apr 24 (ANI): Alcohol is predominantly metabolized through liver, hence its cumulative toxicity over years play important role in liver diseases or pancreatic diseases.

Full Story >>

Washington D.C. [USA], April 24 (ANI): Due to increasing deaths because of prostate cancer among men, US researchers have suggested a special screening more frequently and at an early age to avoid the development of preclinical prostate cancer - that is not symptomatic - to advanced stages.

Full Story >>

Love guzzling diet sodas? Here is why you should NOT

Updated: Apr 24, 2017 07:02 IST     

New York [U.S.], Apr. 24 (ANI): Still downing gallons of diet soda despite knowing that it wrecks your body? Maybe the knowledge of artificially sweetened beverages taking a toll on your brain as well ought to make an impact on your unhealthy habit.

Full Story >>

Washington D.C. [USA], Apr 23 (ANI): A recent study has demonstrated that in the general population, central obesity, insulin resistance, diabetes, lipid abnormalities and high alcohol consumption were the strongest predictors of severe liver disease.

Full Story >>

Breastmilk may help detect your cancer risk

Updated: Apr 23, 2017 11:50 IST     

Washington D.C. [USA], Apr 23 (ANI): Breastmilk might offer clues about a woman's cancer risk, according to a recent research.

Full Story >>

Soon, new weapon in war against obesity

Updated: Apr 23, 2017 11:14 IST     

Washington D.C. [USA], Apr 23 (ANI): A team of scientists has uncovered a potential approach to combat obesity.

Full Story >>

Turns out, being obese is worse than smoking

Updated: Apr 23, 2017 10:52 IST     

Washington D.C. [USA], Apr 23 (ANI): You may want to shed those extra kilos as a recent study has found obesity as a top cause of preventable life-years lost.

Full Story >>

Washington D.C. [USA], Apr 23 (ANI): Testing for molecular markers in the urine of kidney transplant patients could reveal whether the transplant is failing and why, according to a recent research.

Full Story >>

From urine to blood: How antibiotic resistance spreads

Updated: Apr 23, 2017 09:25 IST     

Washington D.C. [USA], Apr 23 (ANI): People with drug-resistant bacteria in their urine or stool samples are at an increased risk of developing Sepsis, a bloodstream infection that is also resistant to certain antibiotics, according to a recent study.

Full Story >>

Move over contact lenses, LASIK is better

Updated: Apr 22, 2017 18:05 IST     

Washington D.C. [USA], April 22 (ANI): Good news for those who underwent LASIK (laser-assisted in situ keratomileusis) for correction of their vision, as a recent study has found that the rate of cornea infection is lower.

Full Story >>

Early detection of oral cancer can increase survival chances

Updated: Apr 22, 2017 08:03 IST     

New Delhi [India], Apr. 22 (ANI): In today's era of booming medical advancements, the chances of survival from cancer can be increased, if it is detected at an early stage.

Full Story >>

Eman Ahmed has done miraculously well: Doctor

Updated: Apr 21, 2017 21:11 IST     

Mumbai (Maharashtra) [India], Apr 21 (ANI): 36-year-old Egyptian Eman Ahmed, who was the heaviest woman in the world at 500-plus kg until a few months ago, has lost 250kg in two months after undergoing surgery here at Saifee Hospital.

Full Story >>