Thu, Apr 27, 2017 | updated 06:28 PM IST

Some cancer cells contains Alzheimer cells too: Study

Updated: Oct 08, 2016 10:47 IST      
Some cancer cells contains Alzheimer cells too: Study

Washington D.C. [USA], Oct. 8 (ANI): A recent study suggests that certain cancer progression proteins and metastasis are stored as amyloid bodies in dormant cancer cells.

Once the amyloid bodies disaggregate, the cancer cells become active again.

Amyloid bodies are known to play a role in the development of neurological diseases such as Alzheimer's and Parkinson's disease but their contributions to the progression of cancer have been largely unknown.

This discovery points to a new avenue for the treatment of various types of cancers by applying knowledge gained from neuroscience to tumor biology.

The author of the study Stephen Lee said, "The amyloid state of protein organization is typically associated with debilitating human neuropathies and rarely observed in physiology,"

Adding, "Yet, we found that a large number of proteins are stored as amyloid bodies in cancer cells that are dormant. The heat shock chaperone pathway can disaggregate the amyloid bodies and turn the dormant cancer cells into active, progressing cancer cells."

The team found that ribosomal intergenic non-coding RNA regulates the process of amyloid formation in cancer cells, making it a target for drug discovery and development.

"If we can stop the amyloid bodies from disaggregating in cancer cells, the hope is that they will remain dormant indefinitely. In addition, we may also be able to turn active cancer cells into dormant ones by encouraging them to store the proteins as amyloid bodies," Lee said.

Amyloidogenesis enables cells to remain viable during prolonged periods of extracellular stress, highlighting the non-toxic and protective nature of the process, not just in cancer cells.

"Following this approach, we wouldn't necessarily rid the body of cancer cells, but we would keep them inactive - shut off, if you will- and not allow them to become active againI am optimistic this could become a novel way of treating cancer. There are already drugs on the market, and others are being studied, that target the ribosomal intergenic noncoding RNA as well as the heat shock chaperone pathway," he said.

The findings were published in the journal Developmental Cell today. (ANI)

Parkinson's disease starts in gut: Study

Updated: Apr 27, 2017 10:03 IST     

Washington D.C. [USA], Apr 27 (ANI): A recent study suggests that parkinson's disease, a disorder of the central nervous system, may start in the gut and spread to the brain via the vagus nerve.

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Lung for Long: Gasp No More

Updated: Apr 26, 2017 18:45 IST     

New Delhi [India], Apr 26 (ANI-Businesswire India): Lungs in Delhi seem to be in dire straits. In the midst of ever thickening air pollution and lifestyle gone astray, lung power is ebbing fast. Data emerging from April 25 lung health camp organized in iconic Press Club of India (PCI) on the occasion of World Asthma Day pressed panic button as regards lung health of the capital city.

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Risk of obesity influenced by changes in our genes

Updated: Apr 26, 2017 15:22 IST     

New Delhi [India], Apr 26 (ANI): According to new study, a child's risk of obesity while growing up can be influenced by modifications to their DNA prior to birth.

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Patient with rare knee cancer undergoes life saving surgery

Updated: Apr 26, 2017 13:52 IST     

New Delhi [India], Apr 26 (ANI): A resident of Ganganager, in Rajasthan, was diagnosed of Large Soft Tissue Sarcoma (9Kg), with Neuro Vascular involvement.

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Here`s how protein impacts intellectual disability

Updated: Apr 26, 2017 07:36 IST     

Washington D.C. [USA], Apr 26 (ANI): A new study has paved the way for the potential treatments of intellectual disability and other neurodevelopmental disorders.

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Stem cells can help identify neuronal defects, suggests Study

Updated: Apr 25, 2017 12:26 IST     

Washington D.C. [USA], Apr 25 (ANI): According to a recent study, the researchers used stem cells derived from patients with Angelman syndrome to identify the underlying cellular defects that cause the rare neurogenetic disorder.

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#WorldMalariaDay: Effective steps to prevent Malaria

Updated: Apr 25, 2017 11:01 IST     

New Delhi [India], Apr 25 (ANI): The theme for World Malaria Day this year is "End Malaria for Good".

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Artificial Intelligence may help in diagnosing Tuberoculosis

Updated: Apr 25, 2017 11:01 IST     

Washington D.C. [USA], Apr 25 (ANI): If you are a patient of Tuberculosis, then we might have some good news for you.

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London [UK], Apr 25 (ANI): According to a new study, only one in five victims with serious injuries caused by child abuse in England and Wales gets treated at a major trauma centre.

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Gene reveals cause of fatal childhood disorder: Study

Updated: Apr 24, 2017 17:51 IST     

New Delhi [India], Apr 24 (ANI): A gene, involved in brain development, which can lead to severe disability and infant death, has been identified by scientists.

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Alcohol: the modern age liver killer

Updated: Apr 24, 2017 17:51 IST     

New Delhi [India], Apr 24 (ANI): Alcohol is predominantly metabolized through liver, hence its cumulative toxicity over years play important role in liver diseases or pancreatic diseases.

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Washington D.C. [USA], April 24 (ANI): Due to increasing deaths because of prostate cancer among men, US researchers have suggested a special screening more frequently and at an early age to avoid the development of preclinical prostate cancer - that is not symptomatic - to advanced stages.

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Love guzzling diet sodas? Here is why you should NOT

Updated: Apr 24, 2017 07:02 IST     

New York [U.S.], Apr. 24 (ANI): Still downing gallons of diet soda despite knowing that it wrecks your body? Maybe the knowledge of artificially sweetened beverages taking a toll on your brain as well ought to make an impact on your unhealthy habit.

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Washington D.C. [USA], Apr 23 (ANI): A recent study has demonstrated that in the general population, central obesity, insulin resistance, diabetes, lipid abnormalities and high alcohol consumption were the strongest predictors of severe liver disease.

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Breastmilk may help detect your cancer risk

Updated: Apr 23, 2017 11:50 IST     

Washington D.C. [USA], Apr 23 (ANI): Breastmilk might offer clues about a woman's cancer risk, according to a recent research.

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Soon, new weapon in war against obesity

Updated: Apr 23, 2017 11:14 IST     

Washington D.C. [USA], Apr 23 (ANI): A team of scientists has uncovered a potential approach to combat obesity.

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Turns out, being obese is worse than smoking

Updated: Apr 23, 2017 10:52 IST     

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Washington D.C. [USA], Apr 23 (ANI): Testing for molecular markers in the urine of kidney transplant patients could reveal whether the transplant is failing and why, according to a recent research.

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From urine to blood: How antibiotic resistance spreads

Updated: Apr 23, 2017 09:25 IST     

Washington D.C. [USA], Apr 23 (ANI): People with drug-resistant bacteria in their urine or stool samples are at an increased risk of developing Sepsis, a bloodstream infection that is also resistant to certain antibiotics, according to a recent study.

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Move over contact lenses, LASIK is better

Updated: Apr 22, 2017 18:05 IST     

Washington D.C. [USA], April 22 (ANI): Good news for those who underwent LASIK (laser-assisted in situ keratomileusis) for correction of their vision, as a recent study has found that the rate of cornea infection is lower.

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