Wed, Apr 26, 2017 | updated 03:27 PM IST

Gut bacteria's secretion may help against kidney stone

Updated: Oct 14, 2016 10:56 IST      
Gut bacteria's secretion may help against kidney stone

Washington D.C. [US], Oct. 14 (ANI): In a recent research, scientists have discovered that factors secreted by gut bacteria might help prevent or treat kidney stones.

Kidney stones can pose serious health problems for people and can increase their risks of developing chronic kidney disease and kidney failure.

Oxalate is a small anion that can complex with calcium to form calcium oxalate kidney stones under certain conditions and elevated urinary excretion of oxalate can be an indicator of increased risk.

The intestines play a crucial role in oxalate balance and Oxalobacter formigenes (Of) is an anaerobic bacterium that lives in the large intestine and utilizes oxalate as its exclusive energy source.

Expert Hatim Hassan and his team found that factors secreted by Of can stimulate oxalate transport by human intestinal cells grown in tissue culture.

The team also revealed that the mechanisms of the observed stimulation involve the PKA signalling pathway and a protein transporter called SLC26A6.

Importantly, Of factors reduced urinary oxalate excretion by 32.5 percent in mice by stimulating colonic oxalate secretion.

"Probiotic bacteria have several health benefits; however, the difficulties in determining intestinal bacterial bioavailability and biosafety concerns when administering live probiotics are potential problems facing current probiotics clinical applications. Developing probiotics-derived factors as novel therapeutic agents is an alternative approach that addresses such concerns," Hassan explained.

Adding, "The fact that these factors retain their biological activity and can effectively reduce urinary oxalate excretion in mice indicates their significant potential as novel therapeutic agents, and provides a compelling reason for the aggressive pursuit of their characterization, which is currently underway."

The findings appear in an upcoming issue of the Journal of the American Society of Nephrology (JASN). (ANI)

Risk of obesity influenced by changes in our genes

Updated: Apr 26, 2017 15:22 IST     

New Delhi [India], Apr 26 (ANI): According to new study, a child's risk of obesity while growing up can be influenced by modifications to their DNA prior to birth.

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Patient with rare knee cancer undergoes life saving surgery

Updated: Apr 26, 2017 13:52 IST     

New Delhi [India], Apr 26 (ANI): A resident of Ganganager, in Rajasthan, was diagnosed of Large Soft Tissue Sarcoma (9Kg), with Neuro Vascular involvement.

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Here`s how protein impacts intellectual disability

Updated: Apr 26, 2017 07:36 IST     

Washington D.C. [USA], Apr 26 (ANI): A new study has paved the way for the potential treatments of intellectual disability and other neurodevelopmental disorders.

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Stem cells can help identify neuronal defects, suggests Study

Updated: Apr 25, 2017 12:26 IST     

Washington D.C. [USA], Apr 25 (ANI): According to a recent study, the researchers used stem cells derived from patients with Angelman syndrome to identify the underlying cellular defects that cause the rare neurogenetic disorder.

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#WorldMalariaDay: Effective steps to prevent Malaria

Updated: Apr 25, 2017 11:01 IST     

New Delhi [India], Apr 25 (ANI): The theme for World Malaria Day this year is "End Malaria for Good".

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Artificial Intelligence may help in diagnosing Tuberoculosis

Updated: Apr 25, 2017 11:01 IST     

Washington D.C. [USA], Apr 25 (ANI): If you are a patient of Tuberculosis, then we might have some good news for you.

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London [UK], Apr 25 (ANI): According to a new study, only one in five victims with serious injuries caused by child abuse in England and Wales gets treated at a major trauma centre.

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Gene reveals cause of fatal childhood disorder: Study

Updated: Apr 24, 2017 17:51 IST     

New Delhi [India], Apr 24 (ANI): A gene, involved in brain development, which can lead to severe disability and infant death, has been identified by scientists.

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Alcohol: the modern age liver killer

Updated: Apr 24, 2017 17:51 IST     

New Delhi [India], Apr 24 (ANI): Alcohol is predominantly metabolized through liver, hence its cumulative toxicity over years play important role in liver diseases or pancreatic diseases.

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Washington D.C. [USA], April 24 (ANI): Due to increasing deaths because of prostate cancer among men, US researchers have suggested a special screening more frequently and at an early age to avoid the development of preclinical prostate cancer - that is not symptomatic - to advanced stages.

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Love guzzling diet sodas? Here is why you should NOT

Updated: Apr 24, 2017 07:02 IST     

New York [U.S.], Apr. 24 (ANI): Still downing gallons of diet soda despite knowing that it wrecks your body? Maybe the knowledge of artificially sweetened beverages taking a toll on your brain as well ought to make an impact on your unhealthy habit.

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Washington D.C. [USA], Apr 23 (ANI): A recent study has demonstrated that in the general population, central obesity, insulin resistance, diabetes, lipid abnormalities and high alcohol consumption were the strongest predictors of severe liver disease.

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Breastmilk may help detect your cancer risk

Updated: Apr 23, 2017 11:50 IST     

Washington D.C. [USA], Apr 23 (ANI): Breastmilk might offer clues about a woman's cancer risk, according to a recent research.

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Soon, new weapon in war against obesity

Updated: Apr 23, 2017 11:14 IST     

Washington D.C. [USA], Apr 23 (ANI): A team of scientists has uncovered a potential approach to combat obesity.

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Turns out, being obese is worse than smoking

Updated: Apr 23, 2017 10:52 IST     

Washington D.C. [USA], Apr 23 (ANI): You may want to shed those extra kilos as a recent study has found obesity as a top cause of preventable life-years lost.

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Washington D.C. [USA], Apr 23 (ANI): Testing for molecular markers in the urine of kidney transplant patients could reveal whether the transplant is failing and why, according to a recent research.

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From urine to blood: How antibiotic resistance spreads

Updated: Apr 23, 2017 09:25 IST     

Washington D.C. [USA], Apr 23 (ANI): People with drug-resistant bacteria in their urine or stool samples are at an increased risk of developing Sepsis, a bloodstream infection that is also resistant to certain antibiotics, according to a recent study.

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Move over contact lenses, LASIK is better

Updated: Apr 22, 2017 18:05 IST     

Washington D.C. [USA], April 22 (ANI): Good news for those who underwent LASIK (laser-assisted in situ keratomileusis) for correction of their vision, as a recent study has found that the rate of cornea infection is lower.

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Early detection of oral cancer can increase survival chances

Updated: Apr 22, 2017 08:03 IST     

New Delhi [India], Apr. 22 (ANI): In today's era of booming medical advancements, the chances of survival from cancer can be increased, if it is detected at an early stage.

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Eman Ahmed has done miraculously well: Doctor

Updated: Apr 21, 2017 21:11 IST     

Mumbai (Maharashtra) [India], Apr 21 (ANI): 36-year-old Egyptian Eman Ahmed, who was the heaviest woman in the world at 500-plus kg until a few months ago, has lost 250kg in two months after undergoing surgery here at Saifee Hospital.

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