Mon, Feb 20, 2017 | updated 04:19 PM IST

Gut bacteria's secretion may help against kidney stone

Updated: Oct 14, 2016 10:56 IST

Washington D.C. [US], Oct. 14 (ANI): In a recent research, scientists have discovered that factors secreted by gut bacteria might help prevent or treat kidney stones.

Kidney stones can pose serious health problems for people and can increase their risks of developing chronic kidney disease and kidney failure.

Oxalate is a small anion that can complex with calcium to form calcium oxalate kidney stones under certain conditions and elevated urinary excretion of oxalate can be an indicator of increased risk.

The intestines play a crucial role in oxalate balance and Oxalobacter formigenes (Of) is an anaerobic bacterium that lives in the large intestine and utilizes oxalate as its exclusive energy source.

Expert Hatim Hassan and his team found that factors secreted by Of can stimulate oxalate transport by human intestinal cells grown in tissue culture.

The team also revealed that the mechanisms of the observed stimulation involve the PKA signalling pathway and a protein transporter called SLC26A6.

Importantly, Of factors reduced urinary oxalate excretion by 32.5 percent in mice by stimulating colonic oxalate secretion.

"Probiotic bacteria have several health benefits; however, the difficulties in determining intestinal bacterial bioavailability and biosafety concerns when administering live probiotics are potential problems facing current probiotics clinical applications. Developing probiotics-derived factors as novel therapeutic agents is an alternative approach that addresses such concerns," Hassan explained.

Adding, "The fact that these factors retain their biological activity and can effectively reduce urinary oxalate excretion in mice indicates their significant potential as novel therapeutic agents, and provides a compelling reason for the aggressive pursuit of their characterization, which is currently underway."

The findings appear in an upcoming issue of the Journal of the American Society of Nephrology (JASN). (ANI)

Children inherit obesity from parents: Study

Updated: Feb 20, 2017 14:54 IST

Washington D.C. (USA), Feb. 20 (ANI): A study reveals that 35-40 percent of a child's 'Body Mass Index' - how fat or thin they are - is inherited from their parents.

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New Delhi [India], Feb 20. (ANI): Good news for all those lazy-headed not-really-a-cleanliness-freak out there! Scientists have found out that the obsession with hygiene could even be turning some beneficial bacteria found in the human gut into "endangered species".

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New Delhi [India], Feb 20. (ANI): In order to persuade someone to quit smoking, it is the 'emotions' that need to be triggered rather than inciting fear in an individual.

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No difference between good or bad diet: Study

Updated: Feb 20, 2017 05:54 IST

New Delhi [India], Feb 20. (ANI): Ever faced a choice between Brown and white bread?

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Washington D.C. [USA], Feb. 19 (ANI): To boost sustainability of livestock production, a study finds that gene editing - one of the newest and most promising tools of biotechnology - enables animal breeders to make beneficial genetic changes, without bringing along unwanted genetic changes.

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People with ADHD may have smaller brain volume

Updated: Feb 19, 2017 07:09 IST

New Delhi [India], Feb 19. (ANI): In a latest study it has been found out that people diagnosed with attention deficit hyperactivity disorder (ADHD) have smaller brain volume than those without the disorder.

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New Delhi [India], Feb 19. (ANI): What if we tell you that scientists can actually slow down the process of ageing. Sounds too good to be true right?

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New Delhi [India], Feb 19. (ANI): Lefty or righty? Well it was decided when you were still in your mum's womb!

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Dads-to be face greater risk of depression

Updated: Feb 19, 2017 06:53 IST

New Delhi [India], Feb 19. (ANI): Expecting a baby is always a joyous experience for both the mother and the father, however a latest study has found out that fathers-to-be can be at risk of depression symptoms if they feel stressed or are in poor health.

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New Delhi [India], Feb 19. (ANI): Do you find it difficult hearing out people at a noisy bar or a restaurant even though you have passed the hearing test with flying colors? Well, you might be secretly deaf!

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New Delhi [India], Feb 19. (ANI): What if we told you that rice has the potential of carrying arsenic and is more than hazardous to feed it to infants!

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Washington D.C. [USA], Feb. 18 (ANI): Now you can save your kid from surgery, as a study shows that antibiotics may be an effective treatment for acute non-complicated appendicitis in children, instead of surgery.

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Washington D.C. [USA], Feb. 18 (ANI): Attention new mommies, sing lullabies to your new born to feel more connected to your babies, suggests a study.

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Washington D.C. [USA], Feb. 18 (ANI): Cancer patients can improve their quality of life with just 30 minutes of walking, suggests a study.

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New Delhi [India], Feb. 17 (ANI): Birth of a baby may be a sweet moment but changing life style of women is posing 'sweet' challenge to it.

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New Delhi [India], Feb. 17 (ANI): Good news! A recent study shows that antibiotics may be an effective treatment for acute non-complicated appendicitis in children, instead of surgery.

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'Seagrass' can improve marine water quality

Updated: Feb 17, 2017 07:07 IST

Washington D.C. [USA], Feb. 17 (ANI): Underwater flowering plants and seagrass meadows known to produce natural antibiotics, can also improve the water quality of sea by suppressing pollution, reveals a study.

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Washington D.C. [USA], Feb. 17 (ANI): Before undergoing hip replacements, knee replacements or hernia repairs, do not let depression or anxiety take a toll on your health, as a study finds, a patients' mental health may affect their risk of experiencing wound-related complications after surgery.

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Washington D.C. [USA], Feb. 17 (ANI): Configure the airflow velocity of your Air Conditioner to a comfortable sleeping environment, as a study reveals when airflow is directed at a human body at an insensible velocity, it may increase your heart rate and affect sleeping positions.

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London [UK], Feb. 17 (ANI): Consume a healthy dose of vitamin D supplements during winters, as a study finds that taking them may protect you from acute respiratory infections and flu.

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