Fri, Feb 24, 2017 | updated 06:32 PM IST

Good news! Drug cocktail of diabetes, hypertension can treat cancer

Updated: Dec 29, 2016 12:09 IST

Washington D.C. [USA], Dec. 29 (ANI): A team of researchers has found that a combination of a diabetes medication and hypertension (high blood pressure) drugs can effectively combat cancer cells.

The study, published in Science Advances, also reported that specific cancer cells respond to this combination of drugs.

The findings indicate the cocktail of these two drugs is effective in a wide range of cancers.

The team led by Michael Hall from the Biozentrum University of Basel in Switzerland made an unexpected discovery: The antihypertensive drug syrosingopine potentiates the anti-cancer efficacy of metformin.

Apparently, this drug combination drives cancer cells to programmed "suicide".

Metformin lowers not only the blood glucose level, but also blocks the respiratory chain in the energy factories of the cell, the mitochondria. The antihypertensive drug syrosingopine inhibits, among other things, the degradation of sugars.

At higher doses, the antidiabetic drug inhibits the growth of cancer cells but could also induce unwanted side effects. Therefore, the researchers screened over a thousand drugs for whether they can enhance the anticancer action of metformin.

"For example, in samples from leukemia patients, we demonstrated that almost all tumor cells were killed by this cocktail and at doses that are actually not toxic to normal cells", said first study author Don Benjamin.

"And the effect was exclusively confined to cancer cells, as the blood cells from healthy donors were insensitive to the treatment," Benjamin added.

In mice with malignant liver cancer, enlargement of the liver was reduced after the therapy. Also the number of tumor nodules was less - in some animals the tumors disappeared completely.

Thus, the drugs interrupt the vital processes which provide energy for the cell. Due to their increased metabolic activity and rapid growth, cancer cells have a particularly high energy consumption, which makes them extremely vulnerable when the energy supply is reduced.

"The data from this study support the development of combination approaches for the treatment of cancer patients," Benjamin noted. (ANI)

Too much sugar may causes Alzheimer's

Updated: Feb 24, 2017 06:13 IST

London [UK], Feb. 24 (ANI): A diet, high in sugar, could lead to Alzheimers, as a study finds a link between sugar and the brain disease.

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New Delhi [India], Feb. 23 (ANI): A study was conducted in 19 centers over a period of six months to understand the different types of constipation and the causes behind them. One of the key highlights has been that constipation is highly prevalent in cities as compared to the rural areas.

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New Delhi [India], Feb 23. (ANI): Never neglect your kid, if you do not want to subject him to mental health issues!

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Now, you can cure insomnia with placebo: Study

Updated: Feb 23, 2017 06:27 IST

Washington D.C. [USA], Feb. 23 (ANI): Briton researchers have found a simple placebo may really work well to cure insomnia.

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Washington D.C. [USA], Feb. 23 (ANI): Beware! US researchers warned that taking drugs to reduce gastric acid for prolonged periods may lead to serious kidney problems, including kidney failure.

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New Delhi [India], Feb. 22 (ANI): In rarest of its kind, a paediatric surgery performed by doctors at a city-based hospital gave a new lease of life to a newborn, suffering from a life-threatening defect of the alimentary canal.

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Beware! Zika can be a reason for miscarriage

Updated: Feb 22, 2017 14:18 IST

Washington D.C. (USA), Feb. 22 (ANI): Beware to-be mothers! According to a recent study, Zika virus could lead to a greater risk of miscarriage in the early stage of pregnancy.

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Washington D.C. (USA), Feb. 22 (ANI): Women with a rare type of epithelial ovarian or peritoneum cancer, can now take sigh of relief.

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Washington D.C. [USA], Feb. 22 (ANI): Now don't blame those chips and chocolates for you childs extra pounds, as a study says around 35-40 percent of a child's is inherited from their parents.

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Drinking too much may age arteries over time!

Updated: Feb 22, 2017 06:03 IST

Washington D.C. [USA], Feb. 22 (ANI): Excessive boozing over the years might age arteries prematurely, especially in men, putting them at an increased risk for heart disease.

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Chronic knee pain may be treated online

Updated: Feb 21, 2017 06:41 IST

Washington D.C. [USA], Feb. 21 (ANI): A study has found out that an online intervention, combining home exercise and pain-coping skills training, provided substantial clinical benefits for patients suffering from chronic knee pain.

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Washington D.C. [USA], Feb. 21 (ANI): Only exercise is not enough to maintain that figure, which is an after effect of much toil and sweat!

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New Delhi [India], Feb. 20 (ANI): With rising life expectancy, increasingly sedentary lifestyles and surge in incidence of obesity, India is also witnessing a resultant rise in orthopedic problems as a natural corollary.

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Children inherit obesity from parents: Study

Updated: Feb 20, 2017 14:54 IST

Washington D.C. (USA), Feb. 20 (ANI): A study reveals that 35-40 percent of a child's 'Body Mass Index' - how fat or thin they are - is inherited from their parents.

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New Delhi [India], Feb 20. (ANI): Good news for all those lazy-headed not-really-a-cleanliness-freak out there! Scientists have found out that the obsession with hygiene could even be turning some beneficial bacteria found in the human gut into "endangered species".

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New Delhi [India], Feb 20. (ANI): In order to persuade someone to quit smoking, it is the 'emotions' that need to be triggered rather than inciting fear in an individual.

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No difference between good or bad diet: Study

Updated: Feb 20, 2017 05:54 IST

New Delhi [India], Feb 20. (ANI): Ever faced a choice between Brown and white bread?

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Washington D.C. [USA], Feb. 19 (ANI): To boost sustainability of livestock production, a study finds that gene editing - one of the newest and most promising tools of biotechnology - enables animal breeders to make beneficial genetic changes, without bringing along unwanted genetic changes.

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People with ADHD may have smaller brain volume

Updated: Feb 19, 2017 07:09 IST

New Delhi [India], Feb 19. (ANI): In a latest study it has been found out that people diagnosed with attention deficit hyperactivity disorder (ADHD) have smaller brain volume than those without the disorder.

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New Delhi [India], Feb 19. (ANI): What if we tell you that scientists can actually slow down the process of ageing. Sounds too good to be true right?

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