Fri, Jun 23, 2017 | updated 09:08 AM IST

Good news! Drug cocktail of diabetes, hypertension can treat cancer

Updated: Dec 29, 2016 12:09 IST      
Good news! Drug cocktail of diabetes, hypertension can treat cancer

Washington D.C. [USA], Dec. 29 (ANI): A team of researchers has found that a combination of a diabetes medication and hypertension (high blood pressure) drugs can effectively combat cancer cells.

The study, published in Science Advances, also reported that specific cancer cells respond to this combination of drugs.

The findings indicate the cocktail of these two drugs is effective in a wide range of cancers.

The team led by Michael Hall from the Biozentrum University of Basel in Switzerland made an unexpected discovery: The antihypertensive drug syrosingopine potentiates the anti-cancer efficacy of metformin.

Apparently, this drug combination drives cancer cells to programmed "suicide".

Metformin lowers not only the blood glucose level, but also blocks the respiratory chain in the energy factories of the cell, the mitochondria. The antihypertensive drug syrosingopine inhibits, among other things, the degradation of sugars.

At higher doses, the antidiabetic drug inhibits the growth of cancer cells but could also induce unwanted side effects. Therefore, the researchers screened over a thousand drugs for whether they can enhance the anticancer action of metformin.

"For example, in samples from leukemia patients, we demonstrated that almost all tumor cells were killed by this cocktail and at doses that are actually not toxic to normal cells", said first study author Don Benjamin.

"And the effect was exclusively confined to cancer cells, as the blood cells from healthy donors were insensitive to the treatment," Benjamin added.

In mice with malignant liver cancer, enlargement of the liver was reduced after the therapy. Also the number of tumor nodules was less - in some animals the tumors disappeared completely.

Thus, the drugs interrupt the vital processes which provide energy for the cell. Due to their increased metabolic activity and rapid growth, cancer cells have a particularly high energy consumption, which makes them extremely vulnerable when the energy supply is reduced.

"The data from this study support the development of combination approaches for the treatment of cancer patients," Benjamin noted. (ANI)

Washington D.C. [USA], June 23 (ANI): According to a recent clinical trial, intensive blood pressure lowering benefits patients with chronic kidney disease.

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New Delhi, [India], June 22 (ANI): J K Organization, in collaboration with Pushpawati Singhania Hospital and Research Institute Multispecialty Hospital, organized a two-day blood donation camp in New Delhi to collect 4043 units of blood.

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Can your blood group predict heart attack risk?

Updated: Jun 22, 2017 13:12 IST     

New Delhi [India], June 22 (ANI): India is presently witnessing nearly two million heart attacks annually. A heart attack (clinically known as myocardial infarction) is the permanent damage or death of the heart muscles due to lack of oxygen-rich blood. According to reports, heart attack kills one person in every 33 seconds in our country.

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Deficits in attention linked to increased alcohol use

Updated: Jun 22, 2017 13:02 IST     

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Healing garden at your place: Homoeopathy speaks

Updated: Jun 22, 2017 13:01 IST     

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Looking for stone removal procedure?

Updated: Jun 22, 2017 11:48 IST     

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Lack Vitamin D? Your job could be a reason

Updated: Jun 22, 2017 09:35 IST     

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Nerves from foot used to restore vision of 60-year-old

Updated: Jun 19, 2017 19:58 IST     

New Delhi [India], June 19 (ANI): In a first of its kind surgery, a hospital in Mumbai used nerves from the foot of a partially blind 60-year-old woman to help her restore her vision.

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Now, it's easier to blunt sickle cell disease

Updated: Jun 19, 2017 16:28 IST     

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ASSOCHAM highlights shortage of yoga instructors in India

Updated: Jun 19, 2017 13:56 IST     

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What makes patients go against medical advice?

Updated: Jun 19, 2017 12:19 IST     

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Ebola vaccine comes closer to reality

Updated: Jun 19, 2017 11:34 IST     

Washington D.C. [USA], Jun 19 (ANI): The world may soon get a vaccine against the deadly Ebola virus.

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Self-medication misuse looming large in Middle East

Updated: Jun 19, 2017 10:37 IST     

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Washington D.C. [USA], Jun 19 (ANI): With many Americans undergoing needless thyroid biopsies, a team of experts has framed new clinical guidelines that would go a long way toward curbing the problem.

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Obesity can boost infection risk post bypass surgery

Updated: Jun 19, 2017 10:04 IST     

Washington D.C. [USA], Jun 19 (ANI): Obese patients have much higher odds of developing an infection soon after heart bypass surgery, according to a recent study.

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Washington D.C. [USA], June 18 (ANI): A team of researchers has suggested that acceptance and commitment therapy for eight-weeks can significantly reduced the symptoms of depression and anxiety in chronic pain patients.

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