Tue, Jun 27, 2017 | updated 12:43 AM IST

Soon, a faster way to treat depression

Updated: Mar 21, 2017 16:02 IST      
Soon, a faster way to treat depression

Washington D.C. [USA], Mar. 21 (ANI): A new and faster way to treat depression has come closer to reality - thanks to a team of scientists.

Researchers at University of California San Diego School of Medicine discovered that inhibiting an enzyme called Glyoxalase 1 (GLO1) relieves signs of depression in mice. Moreover, inhibiting GLO1 worked much faster than the conventional antidepressant Prozac.

The study provides a target for the development of a completely new class of faster-acting antidepressant medications.

"Depression affects at least one in six of us at some point in our lifetime, and better treatments are urgently needed," said senior author Abraham Palmer, adding "A better understanding of the molecular and cellular underpinnings of depression will help us find new ways to inhibit or counteract its onset and severity."

Palmer and team unraveled a previously underappreciated molecular process that can influence mouse models of depression. Here's how the process works: Cells generate energy. In doing so, they produce a byproduct. That byproduct inhibits neurons and thus influences various behaviors. Typically, the enzyme GLO1 removes this byproduct, but inhibiting GLO1 can also increase the activity of certain neurons in a beneficial way. In mice, Palmer and others have shown that more GLO1 activity makes mice more anxious, but less was known about the system's effect on depression.

While this new approach to treating depression has so far only been tested in mice and it will take many years of development before a GLO1 inhibitor could be tested in humans, the researchers are excited to find that new, unexplored approaches to treating depression are out there.

"There are currently no approved fast-acting antidepressants, so finding something like this is unusual," said co-author Stephanie Dulawa.

The study is published in journal Molecular Psychiatry. (ANI)

Untreated polyarthritis can deform joints permanently

Updated: Jun 26, 2017 13:45 IST     

New Delhi [India], June 26 (ANI): Chikungunya, the bone breaking fever, being one of the reasons for polyarthritis , may become a rampant disorder.

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Education, training needed to help human trafficking victims

Updated: Jun 26, 2017 12:17 IST     

Washington D.C. [USA], Jun 26 (ANI): Knowing a little bit more about human trafficking could help save someone and so, a recent research has highlighted the need for education and training.

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Boozing makes ageing clock tick faster

Updated: Jun 26, 2017 10:57 IST     

Washington D.C. [USA], Jun 26 (ANI): Next time you reach for that glass of whiskey, you may want to rethink as a recent research has revealed that the more alcohol you drink, the more your cells appear to age.

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Improving cancer detection with help of body noise

Updated: Jun 26, 2017 07:40 IST     

Washington D.C. [USA], Jun 26 (ANI): According to a recent research, body's own 'seismic noise' can help improve the cancer detection.

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Wound healing goes up in cigarette smoke

Updated: Jun 26, 2017 07:35 IST     

Washington D.C. [USA], Jun 26 (ANI): When it comes to wound healing, vaping may be better than cigarette smoking, according to a recent research.

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Paracetamol during pregnancy can put unborn boys at risk

Updated: Jun 25, 2017 14:45 IST     

New Delhi [India] June 24, (ANI): Pregnant? You may want to rethink popping those paracetamol pills as a recent study has suggested that doing so can harm the masculinity of your unborn son.

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Excessive texting is bad for your wrists

Updated: Jun 25, 2017 11:48 IST     

New York [US], June 25 (ANI): Texting, the thing we do most with our phones, takes a toll on our health.

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Ozone exposure ups autism odds in at-risk people

Updated: Jun 24, 2017 19:47 IST     

Washington D.C. [USA], Jun 24 (ANI): Elevated exposure to ozone can put individuals with high levels of genetic variation at an even higher risk for developing autism than would be expected by adding the two risk factors together, according to a recent analysis.

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Washington D.C. [USA], June 24 (ANI): People suffering from advanced kidney cancer, we have some good news for you.

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Washington D.C. [USA], June 24 (ANI): In a recent study, leisure activities like going for a walk outside, reading, listening to music and other fun activities can reduce blood pressure for elderly caregivers of spouses with Alzheimer's disease.

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Anti-epilepsy drug to treat Alzheimer's disease?

Updated: Jun 24, 2017 10:09 IST     

Washington D.C. [USA], June 24 (ANI): According to a recent study, the scientists have tested an anti-epileptic drug for its potential impact on the brain activity of patients with mild Alzheimer's disease.

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Take these measures to keep oral cancer at bay

Updated: Jun 23, 2017 16:04 IST     

New Delhi [India], June 23 (ANI): Oral Cancer is one of the most prevalent forms of cancer in India. Evidence suggests that India bears the largest burden of oral cancers in the world, with an incidence of around 11.28 percent in Indian men.

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Don't eat but sleep, to beat office blues!

Updated: Jun 23, 2017 10:59 IST     

Washington D.C. [USA], June 23 (ANI): Stressful day at work leads to binge-eating at night. A new study suggests a good night's sleep can serve as a protecting factor between job stress and unhealthy eating in the evening.

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Washington D.C. [USA], June 23 (ANI): According to a recent clinical trial, intensive blood pressure lowering benefits patients with chronic kidney disease.

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New Delhi, [India], June 22 (ANI): J K Organization, in collaboration with Pushpawati Singhania Hospital and Research Institute Multispecialty Hospital, organized a two-day blood donation camp in New Delhi to collect 4043 units of blood.

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Can your blood group predict heart attack risk?

Updated: Jun 22, 2017 13:12 IST     

New Delhi [India], June 22 (ANI): India is presently witnessing nearly two million heart attacks annually. A heart attack (clinically known as myocardial infarction) is the permanent damage or death of the heart muscles due to lack of oxygen-rich blood. According to reports, heart attack kills one person in every 33 seconds in our country.

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Deficits in attention linked to increased alcohol use

Updated: Jun 22, 2017 13:02 IST     

Washington D.C. [USA], June 22 (ANI): Finding it hard to multi-task? Your frequency of alcohol use could be a reason.

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Healing garden at your place: Homoeopathy speaks

Updated: Jun 22, 2017 13:01 IST     

New Delhi [India], June 22 (ANI): One always aspires to be fit and healthy without taking any medicine. If there will be no stress, infections or any other disturbances, there will be no chance of getting ill. But the real world is exactly opposite. There is no life without challenges.

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Looking for stone removal procedure?

Updated: Jun 22, 2017 11:48 IST     

New Delhi [India], June 22 (ANI): Kidneys help in detoxifying and filtering impurities from the blood. They help us excrete excess toxins and excess water through urine.

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Lack Vitamin D? Your job could be a reason

Updated: Jun 22, 2017 09:35 IST     

Washington D.C. [USA], June 22 (ANI): Stuck behind your office desk for most part of the day? Your nine-to-five job could be a major factor that puts you at high risk of Vitamin D deficiency.

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