Sat, Apr 29, 2017 | updated 03:23 AM IST

Soon, a faster way to treat depression

Updated: Mar 21, 2017 16:02 IST      
Soon, a faster way to treat depression

Washington D.C. [USA], Mar. 21 (ANI): A new and faster way to treat depression has come closer to reality - thanks to a team of scientists.

Researchers at University of California San Diego School of Medicine discovered that inhibiting an enzyme called Glyoxalase 1 (GLO1) relieves signs of depression in mice. Moreover, inhibiting GLO1 worked much faster than the conventional antidepressant Prozac.

The study provides a target for the development of a completely new class of faster-acting antidepressant medications.

"Depression affects at least one in six of us at some point in our lifetime, and better treatments are urgently needed," said senior author Abraham Palmer, adding "A better understanding of the molecular and cellular underpinnings of depression will help us find new ways to inhibit or counteract its onset and severity."

Palmer and team unraveled a previously underappreciated molecular process that can influence mouse models of depression. Here's how the process works: Cells generate energy. In doing so, they produce a byproduct. That byproduct inhibits neurons and thus influences various behaviors. Typically, the enzyme GLO1 removes this byproduct, but inhibiting GLO1 can also increase the activity of certain neurons in a beneficial way. In mice, Palmer and others have shown that more GLO1 activity makes mice more anxious, but less was known about the system's effect on depression.

While this new approach to treating depression has so far only been tested in mice and it will take many years of development before a GLO1 inhibitor could be tested in humans, the researchers are excited to find that new, unexplored approaches to treating depression are out there.

"There are currently no approved fast-acting antidepressants, so finding something like this is unusual," said co-author Stephanie Dulawa.

The study is published in journal Molecular Psychiatry. (ANI)

New blood test may predict diabetes better

Updated: Apr 28, 2017 16:00 IST     

Washington D.C. [USA], Apr 28 (ANI): A team of researchers has come up with a new blood test that may better predict gestational diabetes.

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Turns out, e-cigarettes can help smokers kick the butt

Updated: Apr 28, 2017 14:11 IST     

Washington D.C. [USA], Apr 28 (ANI): Smokers rejoice! As a recent study suggests that your plan to kick the cigarette addiction by turning to the electronic version of butts won't go up in smoke.

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Affordable lab tests now at your doorstep

Updated: Apr 28, 2017 06:41 IST     

New Delhi [India], April 28 (ANI): Before going for any medical test, now compare the rates of different path-labs with just a click.

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Deal with depression in natural way

Updated: Apr 28, 2017 03:19 IST     

New Delhi [India], April 28 (ANI): Depression is world's leading illness and is one of the major reasons for suicides globally, says the World Health Organization (WHO). The story in India is no different.

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Parkinson's disease starts in gut: Study

Updated: Apr 27, 2017 10:03 IST     

Washington D.C. [USA], Apr 27 (ANI): A recent study suggests that parkinson's disease, a disorder of the central nervous system, may start in the gut and spread to the brain via the vagus nerve.

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Lung for Long: Gasp No More

Updated: Apr 26, 2017 18:45 IST     

New Delhi [India], Apr 26 (ANI-Businesswire India): Lungs in Delhi seem to be in dire straits. In the midst of ever thickening air pollution and lifestyle gone astray, lung power is ebbing fast. Data emerging from April 25 lung health camp organized in iconic Press Club of India (PCI) on the occasion of World Asthma Day pressed panic button as regards lung health of the capital city.

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Risk of obesity influenced by changes in our genes

Updated: Apr 26, 2017 15:22 IST     

New Delhi [India], Apr 26 (ANI): According to new study, a child's risk of obesity while growing up can be influenced by modifications to their DNA prior to birth.

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Patient with rare knee cancer undergoes life saving surgery

Updated: Apr 26, 2017 13:52 IST     

New Delhi [India], Apr 26 (ANI): A resident of Ganganager, in Rajasthan, was diagnosed of Large Soft Tissue Sarcoma (9Kg), with Neuro Vascular involvement.

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Here`s how protein impacts intellectual disability

Updated: Apr 26, 2017 07:36 IST     

Washington D.C. [USA], Apr 26 (ANI): A new study has paved the way for the potential treatments of intellectual disability and other neurodevelopmental disorders.

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Stem cells can help identify neuronal defects, suggests Study

Updated: Apr 25, 2017 12:26 IST     

Washington D.C. [USA], Apr 25 (ANI): According to a recent study, the researchers used stem cells derived from patients with Angelman syndrome to identify the underlying cellular defects that cause the rare neurogenetic disorder.

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#WorldMalariaDay: Effective steps to prevent Malaria

Updated: Apr 25, 2017 11:01 IST     

New Delhi [India], Apr 25 (ANI): The theme for World Malaria Day this year is "End Malaria for Good".

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Artificial Intelligence may help in diagnosing Tuberoculosis

Updated: Apr 25, 2017 11:01 IST     

Washington D.C. [USA], Apr 25 (ANI): If you are a patient of Tuberculosis, then we might have some good news for you.

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London [UK], Apr 25 (ANI): According to a new study, only one in five victims with serious injuries caused by child abuse in England and Wales gets treated at a major trauma centre.

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Gene reveals cause of fatal childhood disorder: Study

Updated: Apr 24, 2017 17:51 IST     

New Delhi [India], Apr 24 (ANI): A gene, involved in brain development, which can lead to severe disability and infant death, has been identified by scientists.

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Alcohol: the modern age liver killer

Updated: Apr 24, 2017 17:51 IST     

New Delhi [India], Apr 24 (ANI): Alcohol is predominantly metabolized through liver, hence its cumulative toxicity over years play important role in liver diseases or pancreatic diseases.

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Washington D.C. [USA], April 24 (ANI): Due to increasing deaths because of prostate cancer among men, US researchers have suggested a special screening more frequently and at an early age to avoid the development of preclinical prostate cancer - that is not symptomatic - to advanced stages.

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Love guzzling diet sodas? Here is why you should NOT

Updated: Apr 24, 2017 07:02 IST     

New York [U.S.], Apr. 24 (ANI): Still downing gallons of diet soda despite knowing that it wrecks your body? Maybe the knowledge of artificially sweetened beverages taking a toll on your brain as well ought to make an impact on your unhealthy habit.

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Washington D.C. [USA], Apr 23 (ANI): A recent study has demonstrated that in the general population, central obesity, insulin resistance, diabetes, lipid abnormalities and high alcohol consumption were the strongest predictors of severe liver disease.

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Breastmilk may help detect your cancer risk

Updated: Apr 23, 2017 11:50 IST     

Washington D.C. [USA], Apr 23 (ANI): Breastmilk might offer clues about a woman's cancer risk, according to a recent research.

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Soon, new weapon in war against obesity

Updated: Apr 23, 2017 11:14 IST     

Washington D.C. [USA], Apr 23 (ANI): A team of scientists has uncovered a potential approach to combat obesity.

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