Thu, Mar 30, 2017 | updated 08:05 PM IST

Insulin-sensitive obese individuals may not be metabolically healthy

Updated: Aug 20, 2016 16:02 IST

Washington D.C, Aug. 20 (ANI): A recent study pointed out that the term 'healthy obesity' that has gained traction over the past 15 years may just be a notion as white fat tissue samples from obese individuals classified as either metabolically healthy or unhealthy actually show nearly identical, abnormal changes in gene expression in response to insulin stimulation.

"The findings suggest that vigorous health interventions may be necessary for all obese individuals, even those previously considered to be metabolically healthy. Since obesity is the major driver altering gene expression in fat tissue, we should continue to focus on preventing obesity," said Mikael Ryden, the author of the study.

Obesity has globally emerged as an epidemic affecting over 600 million people worldwide and significantly escalating the risk of heart disease, stroke, cancer, and type two diabetes.

A recent estimate suggests that up to 30% of obese individuals are metabolically healthy and therefore may need less vigorous interventions to prevent obesity-related complications.

A hallmark of metabolically healthy obesity is high sensitivity to the hormone insulin, which promotes the uptake of blood glucose into cells to be used for energy. However, there are currently no accepted criteria for identifying metabolically healthy obesity, and whether or not such a thing exists is now up for debate.

Reacting to the controversy, Ryden, Carsten Daub, and Peter Arner of the Karolinska Institute assessed responses to insulin in 15 healthy, never-obese participants and 50 obese subjects enrolled in a clinical study of gastric bypass surgery.

The researchers took biopsies of abdominal white fat tissue before and at the end of a two-hour period of intravenous infusion of insulin and glucose. Based on the glucose uptake rate, the researchers classified 21 obese subjects as insulin sensitive and 29 as insulin resistant.

Surprisingly, mRNA sequencing of white fat tissue samples revealed a clear distinction between never-obese participants and both groups of obese individuals.

White fat tissue from insulin-sensitive and insulin-resistant obese individuals showed nearly identical patterns of gene expression in response to insulin stimulation.

These abnormal gene expression patterns were not influenced by cardiovascular or metabolic risk factors such as waist-to-hip ratio, heart rate, or blood pressure. The findings show that obesity rather than other common risk factors is likely the primary factor determining metabolic health.

"Our study suggests that the notion of metabolically healthy obesity may be more complicated than previously thought, at least in subcutaneous adipose tissue. There doesn't appear to be a clear transcriptomic fingerprint that differentiates obese subjects with high or low insulin sensitivity, indicating that obesity per se is the major driver explaining the changes in gene expression," Ryden says.

The study has an important take-home message. "Insulin-sensitive obese individuals may not be as metabolically healthy as previously believed," Ryden says. "Therefore, more vigorous interventions may be necessary in these individuals to prevent cardiovascular and metabolic complications."

It was published in Cell Reports journal. (ANI)

Washington D.C. [USA], Mar. 30 (ANI): It may be time to stop searching for your 'sexual soulmate' as a recent study has suggested that believing in 'the one' can sour your sex life.

Full Story >>

London [UK], Mar.30 (ANI): What if you get to know about a melon that costs as much as a new car?

Full Story >>

Washington D.C. [USA], Mar. 30 (ANI): Forget mirror manicure, soon you will be able to paint your nails with real silver, platinum and gold for healthier fingertips.

Full Story >>

Washington D.C. [USA], Mar. 30 (ANI): You may want to keep your plate devoid of romaine lettuce as a recent study has suggested that common sanitisation practises may not remove all the bacteria present from the crisp veggie.

Full Story >>

New Delhi [India], Mar. 30 (ANI): Renowned author Amish Tripathi has often used unconventional ways to engage his readers and fans during the process of bringing his new book out to them.

Full Story >>

Washington D.C. [USA], Mar. 29 (ANI): A study finds that preserving and promoting natural amenities - clean air, hiking trails, beaches - and quality of life may give a double shot boost to economic growth important for human capital.

Full Story >>

New Delhi [India], Mar. 29 (ANI): DLF Emporio's Design Awards, in their fifth year, honored promising young names in fashion with a glittering awards ceremony.

Full Story >>

Washington D.C. [USA], Mar. 29 (ANI): For a longer life, eat higher proportion of carbohydrates - grains, pulses, vegetables, sweet potato - and about 100 grams of protein in middle-age daily to cut the chances of heart disease, cancer and other diseases in old age, suggests a study.

Full Story >>

London [UK], Mar. 29 (ANI): Ladies, do not hesitate to put on your sexy, body hugging clothes to office any more.

Full Story >>

Washington D.C. [USA], Mar. 29 (ANI): A team of Canadian researchers has found that teenagers, who begin smoking pot as early as 15 or younger, may suffer long-term cognitive impairment, memory loss, physical illnesses and respiratory diseases.

Full Story >>

Drinking tea may prevent you from diabetes

Updated: Mar 29, 2017 12:11 IST

Washington D.C. [USA], Mar. 29 (ANI): After understanding the health benefits of a cup of tea, a study finds that drinking tea can prevent diabetes.

Full Story >>

Washington D.C. [USA], Mar. 29 (ANI): A new research suggests that parents who play Pokemon Go with their kids report a number of side benefits such as including increased exercise, more time spent outdoors and opportunities for family bonding.

Full Story >>

New Delhi [India], Mar. 29 (ANI): PyotrIlyich Tchaikovsky's classical ballet 'Swan Lake', one of classical ballet's most beloved pieces, is set to come alive on the Indian stage as NavrasaDuende, a leading production house, announces to collaborate with Moscow-based Royal Russian Ballet and enthral the Indian audience.

Full Story >>

Philadelphia [US], Mar. 28 (ANI): Mural Arts Philadelphia has created thousands of murals over its more than 30-year history, and each one has a unique story, connecting communities through public art. In 2017, Mural Arts has added new opportunities to hear some of those stories first-hand on several tours that visit a wide swath of neighborhoods across the City of Philadelphia.

Full Story >>

London [UK], Mar. 28 (ANI): While finding a perfect partner seems like a tough job to many, the fact is, the effort that needs to be put in retaining that partner can be a painstaking process.

Full Story >>

New Delhi [India], Mar. 28 (ANI): The 2017 Coachella Valley Music and Arts Festival lineup is now official, and this year's two-weekend extravaganza at the Empire Polo Club in Indio is sure to be one for the ages, with Radiohead, Lady Gaga and Kendrick Lamar headlining the performances between April 14 and April 23.

Full Story >>

New Delhi [India], Mar. 28 (ANI): In an emphatic show of courage and hope, survivors of acid attack victims recently took to the ramp at a unique fashion show at the India Showcase Week, demolishing stigma and redefining the concept of beauty.

Full Story >>

New Delhi [India], Mar. 28 (ANI): From getting your child ready for school to sorting the daily chores- mornings are super hectic for women, especially the working ones.

Full Story >>

This summer, enjoy sweat-free workout

Updated: Mar 28, 2017 12:41 IST

New Delhi [India], Mar. 28 (ANI): As summer draws close, Reebok has yet again come up with an exciting range of its ActivChill apparel for a more sweat-free workout!

Full Story >>