Tue, Feb 28, 2017 | updated 10:55 AM IST

Anti-depressants intake during pregnancy linked with language disorders in kids

Updated: Oct 13, 2016 12:14 IST

Washington D.C. [US], Oct. 13 (ANI): Mothers, who consume anti-depressants at least twice during pregnancy, had a 37 percent increased risk of speech and language disorders among their offspring as compared to those with depression and other psychiatric disorders, who were not treated with antidepressants, found a recent research.

Lead researcher Alan Brown said, "To our knowledge, this is the first study to examine the relationship between maternal anti-depressant use and speech/language, scholastic, and motor disorders in offspring. The study benefited from large sample population and followed the children beyond age 3."

The speech/language disorders included expressive and receptive language disorders and those involving articulation of sounds.

Selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine, citalopram, paroxetine, sertraline, fluvoxamine and escitalopram cross the placenta and enter the fetal circulation.

There are also increasingly used during pregnancy.

Based on a sample of 845,345 single, live births between 1996 and 2010 taken from national registries in Finland, the exposure groups were classified as mothers who purchased SSRIs once or more before or during pregnancy (15,596); those diagnosed with a psychiatric disorder one year before or during pregnancy but did not purchase antidepressants (9,537); and mothers who neither purchased antidepressants nor were given depression-related diagnoses (31,207).

Since the extent of SSRI exposure was greater for mothers with more than one SSRI purchase during the pregnancy, the team also examined exposure by number of purchases (one, two, or more), and conducted two supplemental analyses to determine whether associations between maternal purchases of two or more SSRIs and the risk of speech/language disorders in offspring were further affected by the severity of depression.

The results did not change appreciably and remained statistically significant.

"We believe that our finding about children of mothers who purchased at least two SSRI prescriptions during pregnancy is particularly meaningful because these women are more likely to have taken these medications, and more likely to have been exposed for a longer period and to larger amounts of the SSRI in pregnancy, compared to women who filled only one prescription," noted Brown.

However, in the whole sample, irrespective of number of purchases, the risk of speech/language disorders was increased among offspring of mothers who used SSRI during pregnancy as well as the offspring of mothers with depression and other psychiatric disorders who did not take an SSRI.

There also was no evidence that maternal SSRI exposure was related to academic performance and motor disorders in offspring.

"The strengths of our study include the large, population based birth cohort, prospective data on SSRI purchases during pregnancy, a comparison group of mothers with depression who were not taking antidepressants, and an extensive national register database that included other known confounders," said Brown.

Adding, "However the severity of maternal depression cannot be ruled out as an explanation for the increased childhood speech and language disorders among mothers who filled more than one SSRI prescription, and further study is warranted."

Although they were not able to confirm that the purchased medications were taken, the association between maternal SSRI and clinical speech and language disorders was present only among mothers with more than one SSRI purchase during pregnancy.

In addition, earlier studies have also shown correlations between data from prescription registries and self-reported use of antidepressants.

Results of the research were published online in JAMA Psychiatry. (ANI)

Washington D.C. [USA], Feb. 27 (ANI): Eating apples, pears, citrus fruits, salads and green leafy vegetables above ten portions a day may reduce the chances of heart attack, stroke, cancer and early death, suggests a study.

Full Story >>

New Delhi [India], Feb 27 (ANI): India's number one craft beer brand Witlinger has launched its authentic taste and flavors with the new initiative #NowRolling to enhance consumer knowledge about craft beer with an engaging impact on the Indian Craft Beer scene.

Full Story >>

Washington D.C. [US], Feb. 26 (ANI): Beware and get your stress treated, as a study warns people who suffer from long-term stress may be more prone to obesity.

Full Story >>

Karachi [Pakistan], Feb. 26 (ANI): Plans for Lahore Literary Festival 2017 did not go as well as expected.

Full Story >>

Washington D.C. [US], Feb. 26 (ANI): A study finds, eating nutrient-enriched diet during adolescence or childhood development may alter long-term behaviour and learning among ladies.

Full Story >>

New Delhi [India], Feb. 25 (ANI): Vivek Chaand Sehgal, chairman of the Motherson Sumi Systems Limited (MSSL), has recently been named the EY Entrepreneur of 2016 for its outstanding contribution in the world of entrepreneurship.

Full Story >>

New Delhi [India], Feb 25 (ANI): In your free time for book lovers nothing can be more interesting than spending time with some great food paired with an array of teas while having a favorite novel in hand. Located in the prime location of Delhi, Cha Bar located inside Oxford Bookstore has lots to offer to its customers.

Full Story >>

New York [USA], Feb. 25 (ANI): It's not only the peer pressure that makes kids try alcohol or smoke pot!

Full Story >>

'Straight' women tend to orgasm less!

Updated: Feb 25, 2017 06:27 IST

New York [USA], Feb. 25 (ANI): 'Orgasm gap' is something all have experienced while making love.

Full Story >>

New Delhi [India], Feb. 25 (ANI): A European study has revealed that the majority of university students believe it is the social norm to use drugs like Ritalin to enhance academic performance - despite very few having used stimulants themselves.

Full Story >>

New Delhi [India], Feb. 25 (ANI): "What will they say about you? Maybe they'll say you showed them what's possible."- This is what sports brand Nike has to say through their new commercial, which has gone viral on the Internet.

Full Story >>

Washington D.C. [US], Feb. 24 (ANI): Parents, please take note! A study warns teenagers who self-report feeling drowsy during mid-afternoon, are 4.5 times more likely to commit violent crimes a decade and a half later.

Full Story >>

Washington D.C. [USA], Feb. 24 (ANI): A team of US researchers warn, fathers, who do cocaine at the time of conceiving a child, may be putting their son at risk of learning disabilities and memory loss.

Full Story >>

Washington D.C. [USA], Feb. 24 (ANI): Waring for all the sea food lovers! Consuming fish, rich in mercury may double the risk of developing motor neurone disease.

Full Story >>

New Delhi [India], Feb. 23 (ANI): A two- day annual fest "POLITIA" was organised by political science department of Shyama Prasad Mukherjee college for Women, University of Delhi, on February 20 and 21.

Full Story >>

Washington D.C. [USA], Feb. 23 (ANI): The implementation of state laws for legalising same-sex marriage can significantly reduce the rate of suicide attempts among teenagers, reveals a study.

Full Story >>

Washington D.C. [USA], Feb. 22 (ANI): Beware to-be mothers! Listeria, a common food-borne bacterium, may pose a greater risk of miscarriage in the early stages of pregnancy than appreciated, warns a study.

Full Story >>

New Delhi [India], Feb. 22 (ANI): Theatre is poetry! It's an amalgamation of music, dance and body language which takes the process of emoting to its peak. With the boom of visual digital media, theater had taken a backseat in terms of popularity.

Full Story >>

New Delhi [India], Feb. 22 (ANI): In the day and age of months, sometimes years being spent planning the perfect wedding, reality is often a rude shock when the wedding is over and the marriage begins! This is because no one thinks of asking the questions that really matter!

Full Story >>

London [UK], Feb. 21 (ANI): Looks like Yo-Yo diet is not that bad!

Full Story >>