Sun, Mar 26, 2017 | updated 09:03 AM IST

Research aims at treating infertility in men

Updated: Dec 28, 2016 14:29 IST

Washington D.C. [USA], Dec. 28 (ANI): When sperm are constantly replenished in the adult male body, why does fertility in men diminish with age?

Chinese researchers have found that stimulating the metabolism of stem cells that produce sperms in male body can shed light on new ways to treat infertility in men.

The study was published in the journal of Genes and Develop ment

"So-called Myc genes, which play an important role in stem cells' ability to self-renew," said Takashi Shinohara Kyoto University' in China, who is interested specifically in spermatogonial stem cells (SSCs), which are responsible for producing sperm.

Shinohara added that SSCs are unique, because they are "the only stem cells that transmit genetic information to offspring."

The Shinohara lab demonstrates how the Myc gene regulates the self-renewal of mouse SSCs, via a process of glycolysis control. Glycolysis is a key part of cells' energy-making mechanism.

They injected two types of SSCs into mouse testes: normal cells in some and Myc gene-suppressed in others.

Two months later, they found that the total number of abnormal SSCs was far fewer than normal ones.

Gene analysis showed that the capacity for self-renewal had been compromised, with possibly important implications for sperm production in these mice.

"We found changes in the expression of genes that would slow the cell cycle," Shinohara stated.

In other words, suppressed SSCs could self-renew, but at a slower than normal rate.

"Stimulating the metabolism of SSCs could improve their proliferation. However, more careful study of the molecular pathways is necessary," Shinohara added.

Further study showed that this diminished rate was accompanied by impaired glycolysis, suggesting that the cells were not generating sufficient energy.

"These findings could have important implications for in fertility research in the future," Shinohara noted. (ANI)

New Delhi [India], Mar 25 (ANI): Are you amongst those who have infatuation with Turkey and the Mediterranean region? Are you someone who is in awe of blue, white and yellow hues that give a glimpse of unique culture and goodness of Turkish architecture?

Full Story >>

Washington D.C. [USA], Mar. 25 (ANI): A new study has found that as little as 10 minutes a day of high-intensity physical activity could help some children reduce their risk of developing heart problems and metabolic diseases such as diabetes.

Full Story >>

Mumbai [India], Mar. 25 (ANI): The Indian School of Design and Innovation (ISDI) which is in association with Parsons, The New School of Design, New York, took fashion incubation to a whole new level with the launch of their student's label "Asvaga" on Pernia's Pop-Up Shop. Pernia's Pop-Up Shop is India's first luxury fashion store for men and women.

Full Story >>

New Delhi [India], Mar. 24 (ANI): Various mobile applications are permitting us to track our sleeping patterns, food intake and exercise or workout patterns.

Full Story >>

New Delhi [India], Mar 24 (ANI): Supporting the core theme of the annual 'Earth Hour Day', Radisson Blu Paschim Vihar is all set to ring in the day by participating and turning off the lights for an hour to save energy between 8:30 and 9:30pm.

Full Story >>

New Delhi [India], Mar. 23 (ANI): In a successful FB Live discussion yesterday, author Amish Tripathi and Cabinet Minister of Textiles Smriti Irani discussed how today's women are warriors, fighting many emotional and intellectual battles to create their mark in every field and every sector, around the world.

Full Story >>

Rishikesh [India], March 24 (ANI): Jumpin Heights, India's Extreme Adventure Zone and India's Highest Bungy Jumping Platform successfully completed 50, 000 Bungy Jumps. To mark this success, a gala event was organised that witnessed participation from over hundred jumpers, locals, and the 'Dangal girls' -Fatima Shaikh and Sanya Malhotra, respectively.

Full Story >>

Washington D.C. [U.S.A.], Mar. 24 (ANI): Drinking a pint of ordinary beer, lager or two small pub measure (25 ml) of spirits a day may lower the risk of several, but not all, cardiovascular diseases, suggests a study.

Full Story >>

Washington D.C. [USA], Mar. 24 (ANI): Weight training, walking, hiking, jogging for 12 months may increase the particular hormone associated with bone growth, promoting bone formation, increasing bone density.

Full Story >>

New Delhi [India], Mar. 24 (ANI): Ranking above HIV and malaria, health experts on the occasion of World Tuberculosis day, called for an increase in public awareness on the rising cases of TB among children.

Full Story >>

New Delhi [India], Mar. 24 (ANI): Looking for extravagance but don't want to spend a bomb? Does your hunt for hotels always look for a perfect blend of comfort, luxury and budget? With the influx of 'budget brands' in the hotel segment, there has been an ignition of growth in the Hospitality sector, striking an increase in the number of in-bound vacations by 12 per cent.

Full Story >>

Saluting the spirit of acid-attack survivors

Updated: Mar 24, 2017 06:37 IST

Bengaluru [India], Mar. 24 (ANI): To celebrate the true spirit of womanhood, Housejoy's 'Joy Squad', in association with Atijeevan Foundation in Bengaluru and Chennai; brought joy into the lives of a few acid-attack survivors.

Full Story >>

New Delhi [India], Mar. 23 (ANI): The Grand Venice, largest mall in Greater Noida and India's only mall built on the lines of Italian city of Venice, has recently launched its Ultimate Food Hub Terrazzo.

Full Story >>

New Delhi [India], Mar. 23 (ANI): Shailyy- a born poetess, whose first story was published in Nandan at a tender age of 13 years, has many accolades to her credit.

Full Story >>

New Delhi [India], Mar. 23 (ANI): India is in the midst of a digital transformation and fashion is at the forefront of this change.

Full Story >>

By Somdatta Saha

Full Story >>

New Delhi [India], Mar.22 (ANI): Universal Business School (UBS) has entered into a three year JV agreement with Tata Capital to train the Graduate Trainee participants, which Tata Capital recruits and cherry picks after a stringent selection process from the best campuses across the country. The program is fully residential and is held at the UBS campus in Karjat.

Full Story >>

New Delhi [India], Mar.22 (ANI): Veteran photographer Raghu Rai was on Wednesday conferred with Lifetime Achievement Award at the 6th National Photography Awards.

Full Story >>

Durex gets into denims with Ranveer Singh

Updated: Mar 22, 2017 17:25 IST

New Delhi [India], Mar.22 (ANI): Durex is back again with Bollywood heartthrob, Ranveer Singh to announce the entry into Jeans.

Full Story >>

Washington D.C. [USA], Mar. 22 (ANI): According to a new University of Michigan study, researchers sought to explain how ethnic-racial identity exploration and resolution might affect friendship networks among youth in a diverse setting, as well as their peers over time.

Full Story >>