Sat, Mar 25, 2017 | updated 11:19 AM IST

New catalysis find sheds light on how to make safer drugs

Updated: Aug 05, 2016 11:32 IST

Washington D.C, Aug 5 (ANI): A team of researchers' work in catalysis could aid drug development.

Many molecules have a chemical structure that is "chiral" - they come in two forms, each with an arrangement of atoms that are mirror images of each other.

These "right-handed" and "left-handed" arrangements, called enantiomers, are problematic for industries that make pharmaceuticals and agrochemicals.

Proteins and sugars in the human body exist in only one of the two enantiomers. Yet the catalytic reactions involved in making drugs often produce molecules with both the "right-handed" and "left-handed" arrangements.

"The handedness of molecules that we ingest, such as drugs, can behave differently depending on whether they are left- or right-handed, often with catastrophic consequences," said University of Wisconsin - Milwaukee's Wilfred Tysoe.

That means that drugs have to be synthesized to have only one "handedness." Current chiral catalysts that can accomplish this task mix tightly with the reactants, making them difficult to separate afterwards.

The goal is to develop a solid "chiral" catalyst that can easily be separated from its products. New research helps to bring that goal closer to reality. The researchers uncovered what happens on the surface of a solid chiral catalyst that allows the preferential formation of only one enantiomer of a molecule.

The study is published in the journal Nature Communications. (ANI)

A simple route to developing new sensors

Updated: Mar 25, 2017 11:01 IST

Washington D.C. [USA], Mar. 25 (ANI): Turns out, there's more to a material used for decades to colour food items than meets the eye.

Full Story >>

London [UK], Mar. 24 (ANI): Following a huge explosion of magnetic field and plasma from the Sun's corona, Tasmania's skyline has been aglow in recent days - with vivid purple and green lights illuminating the horizon.

Full Story >>

Washington D.C. [USA], Mar.23 (ANI): What the CRAB!

Full Story >>

Washington D.C. [USA], Mar.23 (ANI): According to a new study, places which have weaker non-medical exemption policies for vaccinations can reduce the likelihood of a measles outbreak 140 to 190 percent by strengthening them.

Full Story >>

Washington D.C. [USA], Mar. 23 (ANI): Higher level of blood sugar and insulin resistance, accompanied by obesity and physical inactivity, is also linked to more rapid decline in cognitive performance, says a new study.

Full Story >>

New Delhi [India], Mar.22 (ANI): Indian Space Research Organisation (ISRO) is working on systems to forecast the natural disasters that could be used as input by States/disaster management agencies.

Full Story >>

Does universe have a time frame?

Updated: Mar 22, 2017 15:11 IST

Washington D.C. [USA], Mar.22 (ANI): Has anybody ever wondered whether our universe has a resting time frame? A researcher is conducting an experiment to find this out.

Full Story >>

Washington D.C.[USA], Mar. 22 (ANI): A recent research suggests that essential microscopic creatures which produce half of the oxygen in the atmosphere can rapidly adapt to global warming.

Full Story >>

Washington D.C. [USA], Mar. 22 (ANI): He already had a research ship, dinosaur and flightless weevil named after him and now, Sir David Attenborough's hat has got another feather in the form of a 430 million-year-old shrimp ancestor.

Full Story >>

Washington D.C. [USA], Mar. 22 (ANI): A team of scientists has brought fresh hope to alcoholics as they are trying to find out whether or not treating the addiction is as simple as popping over-the-counter pills.

Full Story >>

Wild chimps 'surprisingly' live longer!

Updated: Mar 21, 2017 14:01 IST

Washington D.C. [USA], Mar. 21 (ANI): Our close primate relatives, chimpanzees, have longer life span, if kept under the right ecological conditions.

Full Story >>

Restoring Pluto's planetary identity in crisis

Updated: Mar 18, 2017 06:55 IST

Washington D.C. [USA], Mar. 18 (ANI): A decade after Pluto was ousted from the planet lineup, a supporter of the now dwarf planet is fighting to restore its title.

Full Story >>

Washington D.C [USA], Mar. 17 (ANI): The risk of hearing loss from exposure to noises is all around us every day and now, a recent study

Full Story >>

Washington D.C. [USA], Mar. 16 (ANI): Today, over 95 percent of vanilla flavouring used in foods, from cereal to ice cream, is not natural and the production of the synthetic one is taking a toll on

Full Story >>

Washington D.C. [USA], Mar. 16 (ANI): Good news for those who want to continue using fabric softeners but are afraid of risking the environment as a recent study has paved the way for the "greener"

Full Story >>

Washington D.C. [USA], Mar. 16 (ANI): Earth's radiation belts, two doughnut-shaped regions of charged particles encircling our planet,were discovered more than 50 years ago, but their behaviour is still not completely understood.

Full Story >>

New York [U.S.A.], Mar. 13 (ANI): US tech giant Google has announced that using artificial intelligence to identify breast cancer has borne fruitful results.

Full Story >>

Washington D.C. [USA], Mar. 13 (ANI): Turns out, social media is far more accurate than traditional forecasting as a team of researchers has suggested that it can warn us about extreme weather events before they happen- such as hurricanes, storms and floods.

Full Story >>

Washington D.C. [USA], Mar. 13 (ANI): According to a recent study, arsenic molecules might be used to "fish out" the most toxic elements from radioactive nuclear waste - a breakthrough that could make the decommissioning industry even safer and more effective.

Full Story >>

So, how do financial criminals evade laws?

Updated: Mar 13, 2017 09:06 IST

Washington D.C. [USA], Mar. 13 (ANI): Despite preventative measures against bankruptcy fraud and money laundering, criminals are finding ways to exploit differing regulations in the United States and Europe.

Full Story >>