Tue, Feb 28, 2017 | updated 04:08 AM IST

What is the similarity between 'Yin and yang' switch, animal stem cells?

Updated: Aug 10, 2016 13:09 IST

Washington D.C., Aug .10 (ANI): A study says that a molecular switch that flips between different versions of genes could be crucial for maintaining stem cells across all animals from simple flatworms to humans.

The study at Center for Genomic Regulation says that flatworms (also known as planarians) have an incredible capacity for self-renewal, with almost any part of their body able to regenerate a whole new worm in a matter of days.

The researchers found that they 'mix and match' certain parts of their genes in particular ways - a process known as alternative splicing. The same analysis of flatworm cells that had changed into more specific cell types revealed a different mixture of gene parts.

Looking more closely, the team discovered that two families of molecules - CELF and MBNL - work as a kind of 'yin and yang' switch, enabling cells to flip between different patterns of alternative splicing. CELF molecules guide gene splicing patterns linked to self-renewal of stem cells, while MBNL factors favour differentiation.

The study builds on Irimia's previous research showing that MBNL proteins and alternative splicing patterns are important in human and mouse embryonic stem cells as they differentiate into other cell types.

Previously, scientists have discovered certain proteins, known as transcription factors that are important for maintaining embryonic stem cells in mammals.

However, these particular molecules do not play the same roles in the stem cells of invertebrate organisms such as flatworms, which split off from the ancestors of mammals around 600 million years ago, suggesting that they are quite new in evolutionary terms.

"Discovering that this kind of alternative splicing mechanism exists across such a wide evolutionary range suggests that it is very ancient, and may be equally important as transcription factors for giving animal stem cells their unique properties" said lead researcher Manuel Irimia.

"Furthermore, understanding how this 'yin and yang' switch is flipped and activates particular patterns of alternative splicing could one day lead to more improved methods for generating and differentiating stem cells, which could be used be used for regenerative medicine," Irimia added.

The study has been published in eLife. (ANI)

New clues found for nuclear waste cleanup

Updated: Feb 24, 2017 09:35 IST

Washington D.C. (USA), Feb. 24 (ANI): According to a study, the research being done on the chemistry of technetium-99 has boosted the understanding of the challenging nuclear waste and can lead to better cleanup methods.

Full Story >>

Washington D.C. [US], Feb. 24 (ANI): US researchers have suggested that specially trained dogs can be used to find wide-ranging species that are often threatened, sepecially cheetah in a region of Western Zambia.

Full Story >>

Washington D.C. [USA], Feb. 23(ANI): NASA's Spitzer Space Telescope has revealed the first known system of seven Earth-size planets around a single star. Three of these planets are firmly located in the habitable zone, the area around the parent star where a rocky planet is most likely to have liquid water.

Full Story >>

Noida (Uttar Pradesh) [India], Feb.22 (ANI): Germany's Alexander von Humboldt (AvH) Foundation has handed over equipment worth € 20, 000 to Amity University for accelerating research initiatives.

Full Story >>

Washington D.C. (USA), Feb 21 (ANI): The world's first battery to use only hydronium ions as the charge carrier has been been developed by scientists.

Full Story >>

Washington D.C. (USA), Feb. 21 (ANI): According to a new study, Carnegie's Stephen Elardo and Anat Shahar shows that interactions between iron and nickel under the extreme pressures and temperatures similar to a planetary interior can help scientists understand the period in our Solar System's youth when planets were forming and their cores were created.

Full Story >>

Washington D.C. [USA], Feb. 18 (ANI): To boost breeding of endangered poultry breeds, Briton researchers have come up with gene-editing techniques for the rare breeds to use them as surrogates that cannot produce their own chicks.

Full Story >>

Meet 'Bernardbowen'- the new minor planet

Updated: Feb 18, 2017 07:00 IST

Washington D.C. [USA], Feb. 18 (ANI): In a major development, a team of scientists have officially named a minor planet as 'Bernardbowen' that sits in the asteroid belt between Mars and Jupiter.

Full Story >>

New York [USA], Feb. 17 (ANI): NASA has called on the world to help it in the search for the new ninth planet, as anyone from a kindergartener to a 95-year-old, can participate in their new project to find the not-yet-discovered celestial body.

Full Story >>

Washington D.C. [USA], Feb. 9 (ANI): To cut down the number of traffic fatalities, drive less!

Full Story >>

Washington D.C. [USA], Feb. 8 (ANI): According to an international team of astronomers led by researchers from University Of Cambridge, the Magellanic Clouds, the two largest satellite galaxies of the Milky Way, appear to be connected by a bridge stretching across 43,000 light years.

Full Story >>

Washington D.C. [USA], Jan. 25 (ANI): A team of researchers have discovered prehistoric wolf-sized otter fossils with a large head and a powerful jaw, weighing around 100 pounds, in China's Yunnan province.

Full Story >>

Washington D.C. [USA], Jan. 25 (ANI): A study finds that early identification of hearing loss in newborn due to a disease or physical abnormality by birth may help them in better language outcomes as they grow.

Full Story >>

Chennai [India], Jan.14 (ANI-Businesswire India): While "Jallikattu" seems to be the trending topic of discussion in Tamil Nadu at the moment, a silent revolution envisioned by youth icon and late Former President of India, Dr. APJ Abdul Kalam has quietly gained momentum. Ignite-India is a nation-wide innovation platform for student innovators and young entrepreneurs in high schools and colleges. Founded by International swimmer Agnishwar Jayaprakash in 2014, the organization has designed & hosted 96 Regional Innovation Conferences and 3 National Innovation Conferences across 36 cities in India where students competed to showcased their innovative creations. These innovations were judged based on the practicality, creativity & sustainability by technical experts from diverse fields.

Full Story >>

New Delhi [India], Jan. 13 (ANI): New computer simulations have shown that tiny droplets of sulphuric acid resulted in long-lasting cooling, which was a likely contributor to the death of land-living dinosaurs.

Full Story >>

New human organ in digestive system discovered

Updated: Jan 05, 2017 06:27 IST

New Delhi [India], Jan. 5 (ANI): Scientists have discovered what they are calling a new human organ that exists in the digestive system.

Full Story >>

Washington D.C. [USA], January 4 (ANI): Songbirds divorce, pack up and leave and miss their best chances for successful reproduction, courtesy suburban development.

Full Story >>

How do conch shells have such huge variety?

Updated: Jan 04, 2017 05:52 IST

Washington D.C. [USA], January 4 (ANI): Conch shells and its varied shapes and size have always been something that has captivated the eyes of collectors.

Full Story >>

Washington D.C. [USA], Dec. 31 (ANI): A new study finds that despite English being considered the common language of global science, over 30 percent of new scientific reports are published other languages due to which many major findings have been overlooked.

Full Story >>