Fri, Feb 24, 2017 | updated 10:37 PM IST

Inexpensive drug to lessen risk of heart ailments in diabetics

Updated: Aug 26, 2016 16:34 IST

Washington D.C. [US], Aug. 26 (ANI): A recent research has found that if Metformin, a drug commonly prescribed for Type 2 diabetes, is taken by a Type 1 diabetic patient on a routine basis then it could slow the development of the disease and delay heart disease.

Metformin is an inexpensive treatment often used for Type 2 diabetes to lower blood sugar levels by reducing glucose production in the liver and is not prescribed for patients with Type 1 diabetes.

However, a clinical trial has for the first time revealed that Metformin can promote a patient's ability to repair their own damaged blood vessels by increasing vascular stem cells.

Heart disease is the leading cause of illness in diabetic patients, accounting for more than half of all fatalities.

Metformin may be used to lower Type 1 diabetic patients' risk of developing this complication.

Jolanta Weaver, the author of the study said, "This new research is a major development in understanding the best ways to further improve treatment in Type 1 diabetes."

She added, "As the outcome of heart disease is worse in diabetic versus non-diabetic patients, there is a need to identify additional treatment options."

"Metformin could routinely be used by patients with Type 1 diabetes to help lower their chances of developing heart disease, by increasing a repair mechanism created by vascular stem cells released from the bone marrow," she said.

"Our research is an exciting step forward as it may have positive clinical implications for patients with increased risk of cardiovascular disease by improving their treatment options. For the first time, this study has shown that Metformin has additional benefit beyond improving diabetes control when given to patients with relatively well controlled Type 1 diabetes," said Weaver.

"We have established the drug increases patients own vascular stem cells, which will help delay or slowdown heart disease.Our findings also show that the cells associated with damaged blood vessels were reduced, confirming that the repair of blood vessels was taking place in our patients," she said.

Researchers studied a treatment group of 23 people aged between 19-64 years, who had Type 1 diabetes for up to 23 years and had no evidence of heart disease.

Patients were given metformin at a dose they could tolerate, between one to three tablets a day, for eight weeks. Participants were advised to adjust their insulin to keep blood glucose levels safe.

Scientists measured patients' stem cells directly in the blood and also grew stem cells in a test tube, observing how they behaved.

Another cell type was also counted to assess damaged blood vessels.

The participants were matched with nine patients within the same age bracket who took standard insulin treatment and 23 healthy non-diabetic people aged 20-64.

Experts found that the stem cells of patients who took metformin were able to promote the repair of the blood vessels and there was an improvement in how vascular stem cells worked.

Type 1 diabetes is a lifelong autoimmune condition that develops when the pancreas does not produce any insulin, causing a person's blood sugar level to become too high.

It is estimated around 400,000 people in the UK have the condition.

Weaver said: "We have shown that all our patients in the study had their insulin doses reduced after taking metformin and have not suffered any serious adverse effect."

"Patients with Type 1 diabetes may wish to consider discussing with their GP the possibility of adding metformin, even at a very low dose, to the insulin that they are taking. However, care needs to be taken to adjust insulin dose to prevent too low glucose levels," she added.

Findings of the clinical trial were published in the Cardiovascular Diabetology journal and funded by Diabetes Research and Wellness Foundation. (ANI)

New clues found for nuclear waste cleanup

Updated: Feb 24, 2017 09:35 IST

Washington D.C. (USA), Feb. 24 (ANI): According to a study, the research being done on the chemistry of technetium-99 has boosted the understanding of the challenging nuclear waste and can lead to better cleanup methods.

Full Story >>

Washington D.C. [US], Feb. 24 (ANI): US researchers have suggested that specially trained dogs can be used to find wide-ranging species that are often threatened, sepecially cheetah in a region of Western Zambia.

Full Story >>

Washington D.C. [USA], Feb. 23(ANI): NASA's Spitzer Space Telescope has revealed the first known system of seven Earth-size planets around a single star. Three of these planets are firmly located in the habitable zone, the area around the parent star where a rocky planet is most likely to have liquid water.

Full Story >>

Noida (Uttar Pradesh) [India], Feb.22 (ANI): Germany's Alexander von Humboldt (AvH) Foundation has handed over equipment worth € 20, 000 to Amity University for accelerating research initiatives.

Full Story >>

Washington D.C. (USA), Feb 21 (ANI): The world's first battery to use only hydronium ions as the charge carrier has been been developed by scientists.

Full Story >>

Washington D.C. (USA), Feb. 21 (ANI): According to a new study, Carnegie's Stephen Elardo and Anat Shahar shows that interactions between iron and nickel under the extreme pressures and temperatures similar to a planetary interior can help scientists understand the period in our Solar System's youth when planets were forming and their cores were created.

Full Story >>

Washington D.C. [USA], Feb. 18 (ANI): To boost breeding of endangered poultry breeds, Briton researchers have come up with gene-editing techniques for the rare breeds to use them as surrogates that cannot produce their own chicks.

Full Story >>

Meet 'Bernardbowen'- the new minor planet

Updated: Feb 18, 2017 07:00 IST

Washington D.C. [USA], Feb. 18 (ANI): In a major development, a team of scientists have officially named a minor planet as 'Bernardbowen' that sits in the asteroid belt between Mars and Jupiter.

Full Story >>

New York [USA], Feb. 17 (ANI): NASA has called on the world to help it in the search for the new ninth planet, as anyone from a kindergartener to a 95-year-old, can participate in their new project to find the not-yet-discovered celestial body.

Full Story >>

Washington D.C. [USA], Feb. 9 (ANI): To cut down the number of traffic fatalities, drive less!

Full Story >>

Washington D.C. [USA], Feb. 8 (ANI): According to an international team of astronomers led by researchers from University Of Cambridge, the Magellanic Clouds, the two largest satellite galaxies of the Milky Way, appear to be connected by a bridge stretching across 43,000 light years.

Full Story >>

Washington D.C. [USA], Jan. 25 (ANI): A team of researchers have discovered prehistoric wolf-sized otter fossils with a large head and a powerful jaw, weighing around 100 pounds, in China's Yunnan province.

Full Story >>

Washington D.C. [USA], Jan. 25 (ANI): A study finds that early identification of hearing loss in newborn due to a disease or physical abnormality by birth may help them in better language outcomes as they grow.

Full Story >>

Chennai [India], Jan.14 (ANI-Businesswire India): While "Jallikattu" seems to be the trending topic of discussion in Tamil Nadu at the moment, a silent revolution envisioned by youth icon and late Former President of India, Dr. APJ Abdul Kalam has quietly gained momentum. Ignite-India is a nation-wide innovation platform for student innovators and young entrepreneurs in high schools and colleges. Founded by International swimmer Agnishwar Jayaprakash in 2014, the organization has designed & hosted 96 Regional Innovation Conferences and 3 National Innovation Conferences across 36 cities in India where students competed to showcased their innovative creations. These innovations were judged based on the practicality, creativity & sustainability by technical experts from diverse fields.

Full Story >>

New Delhi [India], Jan. 13 (ANI): New computer simulations have shown that tiny droplets of sulphuric acid resulted in long-lasting cooling, which was a likely contributor to the death of land-living dinosaurs.

Full Story >>

New human organ in digestive system discovered

Updated: Jan 05, 2017 06:27 IST

New Delhi [India], Jan. 5 (ANI): Scientists have discovered what they are calling a new human organ that exists in the digestive system.

Full Story >>

Washington D.C. [USA], January 4 (ANI): Songbirds divorce, pack up and leave and miss their best chances for successful reproduction, courtesy suburban development.

Full Story >>

How do conch shells have such huge variety?

Updated: Jan 04, 2017 05:52 IST

Washington D.C. [USA], January 4 (ANI): Conch shells and its varied shapes and size have always been something that has captivated the eyes of collectors.

Full Story >>

Washington D.C. [USA], Dec. 31 (ANI): A new study finds that despite English being considered the common language of global science, over 30 percent of new scientific reports are published other languages due to which many major findings have been overlooked.

Full Story >>