Sun, Feb 26, 2017 | updated 11:45 AM IST

New approach to drug resistance, courtesy Hollywood wizardry

Updated: Sep 09, 2016 14:11 IST

Washington D.C. [USA], Sept. 9 (ANI): Looks like Hollywood wizardry has turned quite helpful for the scientists from Harvard Medical School and Technion-Israel Institute of Technology.

The scientists have designed a simple way to observe how bacteria move as they become impervious to drugs.

The experiments are thought to provide the first large-scale glimpse of the maneuvers of bacteria as they encounter increasingly higher doses of antibiotics and adapt to survive and thrive in them.

To do so, the team constructed a 2-by-4-foot petri dish and filled it with 14 liters of agar, a seaweed-derived jellylike substance commonly used in labs to nourish organisms as they grow.

To observe how the bacterium Escherichia coli adapts to increasingly higher doses of antibiotics, researchers divided the dish into sections and saturated them with various doses of medication. The outermost rims of the dish were free of any drug.

The next section contained a small amount of antibiotic, just above the minimum needed to kill the bacteria and each subsequent section represented a 10-fold increase in dose, with the center of the dish containing 1,000 times as much antibiotic as the area with the lowest dose.

Over two weeks, a camera mounted on the ceiling above the dish took periodic snapshots that the researchers spliced into a time-lapsed montage.

The result was a powerful, unvarnished visualization of bacterial movement, death and survival; evolution at work, visible to the naked eye.

The device, dubbed the Microbial Evolution and Growth Arena (MEGA) plate, represents a simple, and more realistic, platform to explore the interplay between space and evolutionary challenges that force organisms to change and adapt or die, the researchers said.

"We know quite a bit about the internal defense mechanisms bacteria use to evade antibiotics but we don't really know much about their physical movements across space as they adapt to survive in different environments," said study first author Michael Baym.

The researchers caution that their giant petri dish is not intended to perfectly mirror how bacteria adapt and thrive in the real world and in hospital settings, but it does mimic more closely the real-world environments bacteria encounter than traditional lab cultures.

This is because, the researchers say, in bacterial evolution, space, size and geography matter. Moving across environments with varying antibiotic strengths poses a different challenge for organisms than they face in traditional lab experiments that involve tiny plates with homogeneously mixed doses of drugs.

The study has been published in Science. (ANI)

New clues found for nuclear waste cleanup

Updated: Feb 24, 2017 09:35 IST

Washington D.C. (USA), Feb. 24 (ANI): According to a study, the research being done on the chemistry of technetium-99 has boosted the understanding of the challenging nuclear waste and can lead to better cleanup methods.

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Washington D.C. [US], Feb. 24 (ANI): US researchers have suggested that specially trained dogs can be used to find wide-ranging species that are often threatened, sepecially cheetah in a region of Western Zambia.

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Washington D.C. [USA], Feb. 23(ANI): NASA's Spitzer Space Telescope has revealed the first known system of seven Earth-size planets around a single star. Three of these planets are firmly located in the habitable zone, the area around the parent star where a rocky planet is most likely to have liquid water.

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Noida (Uttar Pradesh) [India], Feb.22 (ANI): Germany's Alexander von Humboldt (AvH) Foundation has handed over equipment worth € 20, 000 to Amity University for accelerating research initiatives.

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Washington D.C. (USA), Feb 21 (ANI): The world's first battery to use only hydronium ions as the charge carrier has been been developed by scientists.

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Washington D.C. (USA), Feb. 21 (ANI): According to a new study, Carnegie's Stephen Elardo and Anat Shahar shows that interactions between iron and nickel under the extreme pressures and temperatures similar to a planetary interior can help scientists understand the period in our Solar System's youth when planets were forming and their cores were created.

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Washington D.C. [USA], Feb. 18 (ANI): To boost breeding of endangered poultry breeds, Briton researchers have come up with gene-editing techniques for the rare breeds to use them as surrogates that cannot produce their own chicks.

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Meet 'Bernardbowen'- the new minor planet

Updated: Feb 18, 2017 07:00 IST

Washington D.C. [USA], Feb. 18 (ANI): In a major development, a team of scientists have officially named a minor planet as 'Bernardbowen' that sits in the asteroid belt between Mars and Jupiter.

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New York [USA], Feb. 17 (ANI): NASA has called on the world to help it in the search for the new ninth planet, as anyone from a kindergartener to a 95-year-old, can participate in their new project to find the not-yet-discovered celestial body.

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Washington D.C. [USA], Feb. 9 (ANI): To cut down the number of traffic fatalities, drive less!

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Washington D.C. [USA], Feb. 8 (ANI): According to an international team of astronomers led by researchers from University Of Cambridge, the Magellanic Clouds, the two largest satellite galaxies of the Milky Way, appear to be connected by a bridge stretching across 43,000 light years.

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Washington D.C. [USA], Jan. 25 (ANI): A team of researchers have discovered prehistoric wolf-sized otter fossils with a large head and a powerful jaw, weighing around 100 pounds, in China's Yunnan province.

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Washington D.C. [USA], Jan. 25 (ANI): A study finds that early identification of hearing loss in newborn due to a disease or physical abnormality by birth may help them in better language outcomes as they grow.

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Chennai [India], Jan.14 (ANI-Businesswire India): While "Jallikattu" seems to be the trending topic of discussion in Tamil Nadu at the moment, a silent revolution envisioned by youth icon and late Former President of India, Dr. APJ Abdul Kalam has quietly gained momentum. Ignite-India is a nation-wide innovation platform for student innovators and young entrepreneurs in high schools and colleges. Founded by International swimmer Agnishwar Jayaprakash in 2014, the organization has designed & hosted 96 Regional Innovation Conferences and 3 National Innovation Conferences across 36 cities in India where students competed to showcased their innovative creations. These innovations were judged based on the practicality, creativity & sustainability by technical experts from diverse fields.

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New Delhi [India], Jan. 13 (ANI): New computer simulations have shown that tiny droplets of sulphuric acid resulted in long-lasting cooling, which was a likely contributor to the death of land-living dinosaurs.

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New human organ in digestive system discovered

Updated: Jan 05, 2017 06:27 IST

New Delhi [India], Jan. 5 (ANI): Scientists have discovered what they are calling a new human organ that exists in the digestive system.

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Washington D.C. [USA], January 4 (ANI): Songbirds divorce, pack up and leave and miss their best chances for successful reproduction, courtesy suburban development.

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How do conch shells have such huge variety?

Updated: Jan 04, 2017 05:52 IST

Washington D.C. [USA], January 4 (ANI): Conch shells and its varied shapes and size have always been something that has captivated the eyes of collectors.

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Washington D.C. [USA], Dec. 31 (ANI): A new study finds that despite English being considered the common language of global science, over 30 percent of new scientific reports are published other languages due to which many major findings have been overlooked.

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