Thu, Mar 30, 2017 | updated 08:11 PM IST

Protein drives inflammation in rheumatoid arthritis patients

Updated: Nov 13, 2016 15:51 IST

Washington D.C. [USA], Nov. 13 (ANI): A recent research has found that a certain protein in the body causes inflammation in rheumatoid arthritis patients which in turn will help avoid trial and error when prescribing medications.

It comes down to proteins: specifically, a protein in the body that drives inflammation in the disease, the research found.

The discovery is an important step toward better personalizing rheumatoid arthritis treatment, helping to avoid trial and error when prescribing medications.

Researchers found that patients with a higher amount or higher proportion of an inflammatory protein called type 1 interferon beta compared with another inflammatory protein, type 1 interferon alpha, do not respond as well to tumor necrosis factor inhibitors as others. They looked at white blood cells called monocytes, a major cell type involved in rheumatoid arthritis, and found that those cells behaved differently in one group than in the other.

The discovery paves the way for a more personalized approach to treatment in rheumatoid arthritis based on the biology of a particular patient's disease.

"Investigating these pathways may identify other targets for therapy or other markers that predict treatment response," says first author Theresa Wampler Muskardin, M.D., a rheumatologist at Mayo Clinic in Rochester, Minn. "It will help rheumatologists find the right drug for each patient and spare patients medications that won't work for them."

The Rheumatology Research Foundation funded the study. Mayo rheumatologist Timothy Niewold, M.D., was the study's senior author.

In other studies presented at the meeting, Mayo Clinic researchers found: Sarcoidosis, the growth of tiny clusters of inflammatory cells called granulomas, carries a higher risk of heart disease and venous thromboembolism. Researchers also found there is seasonal variation in the incidence of sarcoidosis: Rates are consistently lower in autumn. Physicians believe that sarcoidosis may be triggered by the body's immune response to environmental factors, such as something inhaled from the air.

The risk of coronary artery disease among patients with polymyalgia rheumatica is 70 percent higher than it is among others.

Heart and circulatory abnormalities are common in Takayasu's arteritis, a form of vasculitis in which large blood vessels become inflamed.

Mayo rheumatologists and cardiologists formed the Mayo Clinic Cardio-Rheumatology Clinic to research and pioneer better prevention, detection and treatment of heart disease and other cardiovascular problems in patients with rheumatic diseases.

The study has been presented at the American College of Rheumatology annual meeting by Mayo Clinic. (ANI)

Dubai [UAE], Mar.30 (ANI): The Amity Institute of Advanced Research and Studies and the Centre for Science and Technology of the Non-Aligned and Other Developing Countries recently organised an international workshop on trends in solar power generation, energy harvesting at Amity's Dubai campus.

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Washington D.C. [USA], Mar. 30 (ANI): A team of researchers has shed some light on how flying birds communicate with each other.

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Now, a 'faster' single-pixel camera

Updated: Mar 30, 2017 10:55 IST

Washington D.C. [USA] Mar. 30 (ANI): A team of researchers has come up with a new technique for faster single-pixel camera.

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Washington D.C. [USA], Mar. 30 (ANI): Astronauts may soon be able to communicate faster to and from space as NASA's advanced laser communications system called LEMNOS has brought speedy connections closer to the reality.

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Washington D.C. [USA], Mar. 30 (ANI): A new class of carbon nanotubes may soon become the next-generation clean-up crew for toxic sludge and contaminated water, a new study suggested.

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New Delhi [India], Mar. 27 (ANI): The increase of devastating weather extremes in summer is likely linked to human-made climate change, mounting evidence shows.

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New Delhi [India], Mar. 27 (ANI): Looks like summer will be yet more unbearable this year, atleast the present weather condition makes us believe so.

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A simple route to developing new sensors

Updated: Mar 25, 2017 11:01 IST

Washington D.C. [USA], Mar. 25 (ANI): Turns out, there's more to a material used for decades to colour food items than meets the eye.

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London [UK], Mar. 24 (ANI): Following a huge explosion of magnetic field and plasma from the Sun's corona, Tasmania's skyline has been aglow in recent days - with vivid purple and green lights illuminating the horizon.

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Washington D.C. [USA], Mar.23 (ANI): What the CRAB!

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Washington D.C. [USA], Mar.23 (ANI): According to a new study, places which have weaker non-medical exemption policies for vaccinations can reduce the likelihood of a measles outbreak 140 to 190 percent by strengthening them.

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Washington D.C. [USA], Mar. 23 (ANI): Higher level of blood sugar and insulin resistance, accompanied by obesity and physical inactivity, is also linked to more rapid decline in cognitive performance, says a new study.

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New Delhi [India], Mar.22 (ANI): Indian Space Research Organisation (ISRO) is working on systems to forecast the natural disasters that could be used as input by States/disaster management agencies.

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Does universe have a time frame?

Updated: Mar 22, 2017 15:11 IST

Washington D.C. [USA], Mar.22 (ANI): Has anybody ever wondered whether our universe has a resting time frame? A researcher is conducting an experiment to find this out.

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Washington D.C.[USA], Mar. 22 (ANI): A recent research suggests that essential microscopic creatures which produce half of the oxygen in the atmosphere can rapidly adapt to global warming.

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Washington D.C. [USA], Mar. 22 (ANI): He already had a research ship, dinosaur and flightless weevil named after him and now, Sir David Attenborough's hat has got another feather in the form of a 430 million-year-old shrimp ancestor.

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Washington D.C. [USA], Mar. 22 (ANI): A team of scientists has brought fresh hope to alcoholics as they are trying to find out whether or not treating the addiction is as simple as popping over-the-counter pills.

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Wild chimps 'surprisingly' live longer!

Updated: Mar 21, 2017 14:01 IST

Washington D.C. [USA], Mar. 21 (ANI): Our close primate relatives, chimpanzees, have longer life span, if kept under the right ecological conditions.

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Restoring Pluto's planetary identity in crisis

Updated: Mar 18, 2017 06:55 IST

Washington D.C. [USA], Mar. 18 (ANI): A decade after Pluto was ousted from the planet lineup, a supporter of the now dwarf planet is fighting to restore its title.

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Washington D.C [USA], Mar. 17 (ANI): The risk of hearing loss from exposure to noises is all around us every day and now, a recent study

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