Cure for baldness comes closer to reality

   Mar 22, 11:59 am

Washington, Mar 22 (ANI): Researchers have discovered an abnormal amount of a protein called Prostaglandin D2 in the bald scalp of men with male pattern baldness.

The discovery by researchers at Perelman School of Medicine at the University of Pennsylvania may lead directly to new treatments for the most common cause of hair loss in men.

In both human and animal models, researchers found that a prostaglandin known as PGD2 and its derivative, 15-dPGJ2, inhibit hair growth.

The PGD2-related inhibition occurred through a receptor called GPR44, which is a promising therapeutic target for androgenetic alopecia in both men and women with hair loss and thinning.

Male pattern baldness strikes 8 of 10 men under 70 years old, and causes hair follicles to shrink and produce microscopic hairs, which grow for a shorter duration of time than normal follicles.

Researchers took an unbiased approach when scanning for potential biological causes of baldness, looking in scalp tissue from balding and non-bald spots from men with male pattern baldness and then corroborating findings in mouse models.

They found that levels of PGD2 were elevated in bald scalp tissue at levels 3 times greater than what was found in comparative haired scalp of men with androgenetic alopecia.

When PGD2 was added to cultured hair follicles, PGD2-treated hair was significantly shortly, while PGD2's derivative, 15-dPGJ2, completely inhibited hair growth.

"Although a different prostaglandin was known to increase hair growth, our findings were unexpected, as prostaglandins haven't been thought about in relation to hair loss, yet it made sense that there was an inhibitor of hair growth, based on our earlier work looking at hair follicle stem cells," said George Cotsarelis, MD, chair and professor of Dermatology, and senior author on the studies.

In a Penn study published last year, underlying hair follicle stem cells were found intact, suggesting that the scalp was lacking an activator or something was inhibiting hair follicle growth.

Prostaglandins are well characterized for their role in many bodily functions - controlling cell growth, constricting and dilating smooth muscle tissue - and a different prostaglandin (F2alpha) is known to increase hair growth.

Researchers found that as PGD2 inhibits hair growth, other prostaglandins work in opposition, enhancing and regulating the speed of hair growth.

While these studies looked at AGA in men, the researchers noted that prostaglandins may represent a common pathway shared by both men and women with AGA.

Future studies, potentially testing topical treat men ts that may target GPR44, can determine whether targeting prostaglandins will benefit woman with AGA as well.

The study has been published in Science Translational Medicine. (ANI)

Ebola cases could rise to 6,800 in West Africa by end of September Sep 20, 12:00 am
Washington, Sept 20 (ANI): A new study has revealed that new Ebola cases could reach 6,800 in West Africa by the end of the month if new control measures are not enacted.
Full Story
New 'game changing' Ebola research improves understanding virus in great apes Sep 19, 6:31 am
Washington, Sept 19 (ANI): A new research in Ebola virus has developed a new method to study the virus in wildlife by describing the use of fecal samples from wild great apes.
Full Story
Ebola infections cross 5000 mark in West Africa: WHO Sep 19, 6:31 am
Johannesburg, Sep 19 (ANI): The World Health Organization (WHO) has reportedly said that the number of people infected by the Ebola virus in West Arica has crossed 5,000.
Full Story
How chronic stress destroys us revealed Sep 19, 6:30 am
Washington, Sept 19 (ANI): A new study has revealed how chronic stress leads to behavioural problems in people.
Full Story
Comments

LATEST STORIES
TOP VIDEO STORIES
PHOTO GALLERY