Control of caloric intake can reverse link between low birth weight and obesity

   Apr 3, 1:53 pm

Washington, April 3 (ANI): A dietary intervention during early life can reverse the tendency of low birth weight babies becoming obese in later life, researchers including one of an Indian origin have suggested.

Babies who are born small have a tendency to put on weight during childhood and adolescence if allowed free access to calories.

However, a new animal model study at UCLA found when small babies were placed on a diet of moderately regulated calories during infancy, the propensity of becoming obese decreased.

Because this is an early study, UCLA researchers do not recommend that mothers of low-birth weight infants start restricting their child's nutrition and suggest they consult with their child's pediatrician regarding any feeding questions.

Previous studies have shown that growth restriction before birth may cause lasting changes of genes in certain insulin-sensitive organs like the pancreas, liver and skeletal muscle.

Before birth, these changes may help the malnourished foetus use all available nutrients. However, after birth these changes may contribute to health problems such as obesity and diabetes.

"This study shows that if we match the level of caloric consumption after birth to the same level that the growth-restricted baby received in the womb, it results in a lean body type. However, if there is a mismatch where the baby is growth-restricted at birth but exposed to plenty of calories after birth, then that leads to obesity," said the lead author, Dr. Sherin Devaskar, professor of pediatrics and executive chair of the department of pediatrics at Mattel Children's Hospital UCLA.

"While many trials that include exercise and various drug therapies have tried to reverse the tendency of low birth weight babies becoming obese, we have shown that a dietary intervention during early life can have long lasting effects into childhood, adolescence and adult life," she stated.

Low birth weight can be caused by malnutrition due to a mother's homelessness or hunger or her desire not to gain too much weight during pregnancy. Additional causes include illness or infection, a reduction in placental blood, smoking or use of alcohol or drugs during pregnancy.

To conduct the study, researchers used rodent animal models and simulated a reduced calorie scenario during pregnancy.

The results showed that low-birth weight offspring exposed to moderately tempered caloric intake during infancy and childhood resulted in lean and physically active adults related to high energy expenditure, as opposed to unrestricted intake of calories, which resulted in inactive and obese adults due to reduced energy expenditure.

The researchers concluded that early life dietary interventions have far reaching effects on the adult state.

Future studies will follow this study over the stages of aging to see if early regulation of calorie intake reverses diabetes and obesity while aging.

"This is an early pre-clinical trial that first needs to be tested in clinical trials before any form of guidelines can be developed," Devaskar said.

"More importantly, we must make sure that control of caloric intake during infancy and childhood does not have any unintended side effects before taking on clinical trials. More research is required to ensure that these metabolic advantages will persist later in life," she added.

The study appears in the June issue of the journal Diabetes and is currently available online.(ANI)

Cooking gas stoves at home associated with childhood asthma Sep 30, 5:31 pm
Washington, Sept 30 (ANI): Scientists have found that ventilation while cooking with a gas stove is essential, as the lack of it was linked to childhood asthma.
Full Story
Opioid painkillers carry high risk of addiction, even death Sep 30, 4:18 pm
Washington, Sept 30 (ANI): A new research has revealed that opioid painkillers carry higher risk of death, overdose, addiction or serious side effects than benefits in chronic, non-cancer conditions like headache, fibromyalgia and chronic low back pain.
Full Story
Avigan Tablet 200mg administered to a French woman infected with Ebola virus Sep 30, 4:18 pm
Tokyo, Sept.30 (ANI): FUJIFILM Corporation announced that the anti-influenza drug 'Avigan(r) Tablet 200mg' (Favipiravir), developed by the Fujifilm Group company Toyama Chemical Co., Ltd, has been administered to a patient infected with the Ebola virus disease at a hospital in France.
Full Story
Eating apples helps prevent obesity disorders Sep 30, 2:39 pm
Washington, Sept 30 (ANI): A new study has examined that nondigestible compounds in apples may help prevent disorders associated with obesity.
Full Story
Comments

LATEST STORIES
TOP VIDEO STORIES
PHOTO GALLERY