Perfect drug combos to combat severe diseases come closer to reality

   Oct 24, 7:37 pm

London, Oct 24 (ANI): Researchers have found a way of identifying ideal drug combinations, which could help prevent inflammation.

These findings could be the first step in the development of new drug combinations to combat severe diseases and conditions.

The multi-disciplinary team of researchers, led by Professor Douglas Kell, Professor of Bioanalytical Science at The University of Manchester, developed an evolutionary computer programme, which rapidly sifted through nine billion different combinations of potential drugs.

Sorting and testing 50 drug combinations at a time using robotics in the laboratory, the scientists were able to find effective combinations and then refine them as many times as necessary to find ideal combinations.

Ultimately, they hope this will lead to the development of tailored therapies for treating inflammation.

"Most diseases have complex causes. This makes their analysis a problem of systems biology, and to find novel therapies multiple targets need to be attacked at once," Professor Kell, who is also Chief Executive of the Biotechnology and Biological Sciences Research Council, said.

"We have devised a strategy, based on Darwinian evolution, to make this considerably easier. Although our immediate interest is inflammation and conditions such as stroke, our approach is universal and is thus applicable to all complex diseases."

Another advantage of choosing ideal drug combinations is that it allows patients to take smaller doses, which reduces potential toxicology concerns.

The findings have been published in Nature Chemical Biology. (ANI)

Scientists discover 'chink in HIV's armour' Oct 25, 12:41 pm
Washington, Oct 25 (ANI): Scientists have found a new protein, called Ssu72 that seems to be part of a switch used to awaken HIV-1 (the most common type of HIV) from its slumber.
Full Story
Highest altitude human occupation 1 millennia earlier than previously documented Oct 24, 3:59 pm
Washington, Oct 24 (ANI): An archaeological team has found evidence of the highest altitude human occupied land in the southern Peruvian Andes dated 900 years earlier than previously documented.
Full Story
Scientists shed new light on how hormone works in weight loss Oct 24, 2:30 pm
Washington, Oct 24 (ANI): Scientists have found the how the hormone, which is a popular target to develop weight-loss drugs, works in our body.
Full Story
Hunchback 'Horrible Hands' dino had 'incredibly' long arms Oct 24, 1:57 pm
Washington, Oct 24 (ANI): A new study examined the new fossils of an "incredibly" long-armed dinosaur nicknamed "Horrible Hands" and demonstrated that the dinosaur had a prominent hunchback, was omnivorous, and had features that prevented it from sinking into wet ground.
Full Story
Comments

LATEST STORIES
TOP VIDEO STORIES
PHOTO GALLERY