Perfect drug combos to combat severe diseases come closer to reality

   Oct 24, 7:37 pm

London, Oct 24 (ANI): Researchers have found a way of identifying ideal drug combinations, which could help prevent inflammation.

These findings could be the first step in the development of new drug combinations to combat severe diseases and conditions.

The multi-disciplinary team of researchers, led by Professor Douglas Kell, Professor of Bioanalytical Science at The University of Manchester, developed an evolutionary computer programme, which rapidly sifted through nine billion different combinations of potential drugs.

Sorting and testing 50 drug combinations at a time using robotics in the laboratory, the scientists were able to find effective combinations and then refine them as many times as necessary to find ideal combinations.

Ultimately, they hope this will lead to the development of tailored therapies for treating inflammation.

"Most diseases have complex causes. This makes their analysis a problem of systems biology, and to find novel therapies multiple targets need to be attacked at once," Professor Kell, who is also Chief Executive of the Biotechnology and Biological Sciences Research Council, said.

"We have devised a strategy, based on Darwinian evolution, to make this considerably easier. Although our immediate interest is inflammation and conditions such as stroke, our approach is universal and is thus applicable to all complex diseases."

Another advantage of choosing ideal drug combinations is that it allows patients to take smaller doses, which reduces potential toxicology concerns.

The findings have been published in Nature Chemical Biology. (ANI)

Simple computer test can help detect early signs of Alzheimer's Sep 22, 6:37 pm
Washington, Sept 22 (ANI): A new study has revealed that a simple test that combines thinking and movement can help to detect heightened risk for developing Alzheimer's disease in a person, even before there are any telltale behavioural signs of dementia.
Full Story
Researchers find new approach to fight against 'superbugs' Sep 22, 4:58 pm
Washington, Sep 22 (ANI): A new study has provided a deeper insight into the new approaches that the researchers are adopting in order to fight against superbugs.
Full Story
Newborn babies' immune system stronger than previously believed Sep 22, 2:29 pm
Washington, Sept 22 (ANI): Scientists have found that the immune system of newborn babies is actually stronger than what was believed earlier.
Full Story
CO2 emissions set to reach all time high record of 40 bln tones in 2014 Sep 22, 10:59 am
Washington, Sept 22 (ANI): A new study has revealed that global Carbon dioxide emissions are set to reach a record high of 40 billion tones in 2014.
Full Story
Comments

LATEST STORIES
TOP VIDEO STORIES
PHOTO GALLERY