Possible receptor for key breast cancer regulator identified

   Jan 14, 12:30 pm

Washington, Jan 14 (ANI): Researchers have identified a key protein potentially involved in regulating breast cancer progression.

Researchers at Clarkson University in Potsdam, N.Y. led by professor Costel Darie, worked to identify the binding partner of Tumor Differentiating Factor (TDF), a pituitary hormone that had previously been shown to reduce cancer progression in breast cancer cells.

Earlier studies had shown that breast cancer cells treated with TDF lost their cancerous characteristics and began acting like normal mammary cells, suggesting that TDF had tumor-suppressing capabilities.

However, how TDF acted remained unclear, leading Darie's group to initiate a search for a cellular receptor in cancer cells that might bind TDF and transmit its anti-tumorigenic cues.

Darie's group found that a receptor, labeled TDF-R, was found exclusively in breast, but not other cancer, cells, suggesting a level of specificity that agrees with previous reports of the efficacy of TDF.

This result has substantial potential implications for developing new therapies for treating breast cancers known to be unresponsive to standard steroid hormone-based therapies, such as tamoxifen treatment.

Looking toward the next step, Darie asserted that "finding the receptor for the TDF hormone will allow us to rationally design drugs that will have a potent ability to stop cancer progression."

"We will also be able to use TDF as a biomarker for breast cancer onset, thereby improving diagnoses," he added.

The finding will be reported in a forthcoming issue of the Journal of Biological Chemistry. (ANI)

One-third of autistic kids likelier to wander off May 1, 11:45 am
Washington D.C, May 1 (ANI): Kids with autism spectrum disorder (ASD) have a tendency to wander away from an adult or caregiver, according to a recent study.
Full Story
Retweeting makes you forget what you read Apr 30, 12:33 pm
Washington D.C, Apr 30 (ANI): If you want to remember an interesting post that you came across on the social media, try not to hit the retweet or share button as a recent study suggests so.
Full Story
Air pollutants put you at risk of numerous cancers Apr 30, 12:24 pm
Washington D.C, Apr 30 (ANI): A team of researchers has linked long-term exposure to environmental pollutants to an increased risk of mortality from many types of cancer in an elderly Hong Kong population.
Full Story
World's largest dinos were born self-reliant Apr 30, 11:10 am
Washington D.C, Apr 30 (ANI): If remains of baby Titanosaur is anything to go by, they probably were almost independent from the moment they were born.
Full Story
Comments