Japanese traditional therapy may help prevent inflammatory brain damage

   Mar 19, 2:16 pm

Washington, Mar 19 (ANI): A compound used in traditional Japanese medicine, honokiol (HNK), plays a role in blocking key protein in inflammatory brain damage, a new study led by Indian origin scientist has suggested.

Microglia are the first line defence of the brain and are constantly looking for infections to fight off.

Overactive microglia can cause uncontrolled inflammation within the brain, which can in turn lead to neuronal damage.

New research shows that HNK is able to down-regulate the production of pro-inflammatory cytokines and inflammatory enzymes in activated microglia via Klf4, a protein known to regulate DNA.

Scientists from the National Brain Research Centre, Manesar, India, used lipopolysaccharide (LPS), a molecule present on the surface of bacteria, to stimulate an immune response from microglia cells.

LPS mimics the effect of a bacterial infection and the microglia cells spring into action, releasing proinflammatory cytokines, such as TNFa.

Activation of microglia also stimulates the production of nitric oxide (NO) and Cox-2, which co-ordinate the immune response, leading to inflammation.

However uncontrolled inflammation can lead to neuronal death and permanent brain damage.

Microglial inflammation is also observed in several neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and multiple sclerosis.

The team led by Dr Anirban Basu found that the inflammatory response was mediated by Klf4, a 'transcription' factor which binds directly to DNA to enhance or impede gene expression.

Treating microglia with HNK reduced their activation and HNK treated cells secreted less cytokines in response to LPS.

HNK also down regulated the activity of Klf4 (and pNF-kb - another regulator of inflammation).

Dr Basu suggested that HNK down regulates Klf4 which in turn down regulates NO and Cox-2 production.

"HNK can easily move across the blood brain barrier and we found that HNK reduced levels of pNF-kb and Klf4 as well as the number of activated microglia in the brains of LPS treated mice," he said.

"Our work with HNK has found that Klf4 is an important regulator of inflammation. Both HNK and Klf4 may be important not only in regulating inflammation due to infection, but may also have applications in other diseases which affect the brain and nervous system," he added.

The study has been published in BioMed Central's open access journal Journal of Neuroinflammation. (ANI)

Pain kills sex drive in female mice Apr 23, 4:45 pm
Washington, April 23 (ANI): A new study has revealed that pain curbs sex drive in female mice, however it was found that it had no effect on male mice.
Full Story
How Facebook 'unfriending' affects emotionally Apr 23, 4:45 pm
Washington, April 23 (ANI: A new study has revealed how Facebook unfriending is associated with a range of emotions.
Full Story
Heart attacks could soon be history Apr 23, 3:21 pm
Washington, Apr 23 (ANI): Johns Hopkins scientists have found a way to block abnormal cholesterol production, transport and breakdown, successfully preventing the development of atherosclerosis, the main cause of heart attacks and strokes and the number-one cause of death among humans.
Full Story
People pay more attention to upper half of what they see Apr 23, 3:21 pm
Washington, Apr 23 (ANI): A new study from North Carolina State University and the University of Toronto has found that people pay more attention to the upper half of their field of vision.
Full Story
Comments

LATEST STORIES
TOP VIDEO STORIES
PHOTO GALLERY