Inflammatory component behind major eye disease identifiedApr 9, 2:58 pm
London, Apr 9 (ANI): Researchers have discovered that a part of the immune system called the inflammasome is involved in regulating the development of one of the most common forms of blindness, called Age-Related Macular Degeneration (AMD).Scientists at Trinity College Dublin have found that controlling an inflammatory component IL-18, in cases of AMD could prevent the development of the disease.The disease AMD involves loss of central vision, people with advanced disease being unable to read, watch TV, enjoy the cinema, drive, or use a computer - in short, everyday living becomes very difficult. The key diagnostic feature of AMD is the presence of "drusen", which are recognised during an eye exam as yellowish/white deposits in the central region of the retina called the macula. Dry AMD is characterised by the presence of excessive amounts of drusen and there are currently no forms of therapy other than recommended lifestyle changes such as giving up smoking, which is a recognised risk factor. However, a significant number of cases of the "dry" form of AMD can progress to the "wet" form, where blood vessels underneath the retina begin to grow, leading to central blindness. If you hold two coins immediately in front of your eyes, you will see a single large black circle blocking out your central vision. This is a very realistic simulation of what it is like to live with advanced disease.The leading co-authors of the paper, Trinity College scientists, Dr Sarah Doyle and Dr Matthew Campbell have together discovered that drusen accumulating in the macula can lead to the production of two inflammatory components termed IL-1beta and IL-18. These findings were based on studies involving drusen isolated from donor AMD eyes in tandem with pre-clinical studies on models of the disease."Traditionally, inflammation in the retina or indeed the eye in general is not beneficial and is a pathological hallmark of many eye diseases, including AMD. However we have identified, that one inflammatory component termed IL-18 acts as a so-called anti-angiogenic factor, preventing the progression of wet AMD" said Dr. Campbell."The progression from "dry" to "wet" AMD appears to be mediated by the inflammatory component IL-18, our results directly suggest that controlling or indeed augmenting the levels of IL-18 in the retinas of patients with dry AMD could prevent the development of the wet form of disease, which leads us to an exciting new prospect for a novel therapy for AMD" added Dr Doyle.The study has been published in the international medical journal, Nature Medicine. (ANI)
Global variations in malaria parasites revealed Jun 28, 1:20 pm
Washington D.C, Jun 28 (ANI): A team of scientists has found that the malaria parasite Plasmodium vivax is evolving rapidly to adapt to conditions in different geographical locations.Full Story »
Texting changes your brain's rhythm Jun 28, 12:28 pm
Washington D.C, Jun 28 (ANI): There is now a biological reason why you shouldn't text and drive as new study has found that messaging with smartphones can change the rhythm of brain waves.Full Story »
This is your brain when buying music Jun 28, 11:27 am
Washington D.C, Jun 28 (ANI): What happens in the brain when purchasing music? A team of researchers has investigated this question.Full Story »
This new technique will help your shampoos' flow freely Jun 27, 3:20 pm
Washington, D.C., June 27 (ANI) A new study has found a way through which soap products can flow freely.Full Story »
- LIGO may detect formation of black-hole binary stars: Study
- Driverless cars pose 'safety dilemma'
- Scientists have new theory on how 'climate' affects 'violence'
- Dinosaur-era bugs knew how to camouflage
- Earth's present magnetic field isn't 'same old, same old'
- Global warming forecast: Even warmer days ahead
- For volcanoes, 'calm before the storm' holds true
- Soon, waste water may power Kerala homes
- Your win lies in the `eyes` of opponent
- 'Coral zombies' may eat away world's reefs
TOP VIDEO STORIES