New MRI technique predicts progression of dementia

   Apr 11, 4:21 pm

Washington, April 11 (ANI): A new technique uses magnetic resonance imaging (MRI) to predict the rate of progression and physical path of many degenerative brain diseases.

Developed by scientists at the San Francisco VA Medical Center and the University of California, San Francisco, the technique also supports mounting evidence that dementias spread through the brain along specific neuronal pathways in the same manner as prion diseases.

The scientists employed new computer modelling techniques to realistically predict the physical progression of Alzheimer's disease and frontotemporal dementia (FTD) using images of 14 healthy brains.

The models were based on whole-brain tractography, an MRI technique that maps the neural pathways, or "communication wires," that connect different areas of the brain.

The spread of disease along those pathways, as predicted by the models, closely matched actual MRI images of brain degeneration in 18 Alzheimer's patients and 18 FTD patients.

"The results need to be replicated, but they suggest that, by using this approach, we can predict the location and course of future brain atrophy in Alzheimer's, FTD and other degenerative brain diseases , based on just one MRI taken at the outset of the disease," said senior author Michael Weiner, MD, director of the SFVAMC Center for Imaging of Neurodegenerative Diseases.

"This would be extremely useful in planning treatment, and in helping patients and families know what to expect as dementia progresses," he noted.

Weiner, who is also a UCSF professor of radiology, medicine, psychiatry and neurology, said that the results were "consistent with an emerging concept that brain damage occurs in these neurodegenerative diseases in a diffusive, prion-like propagation."

A prion is an infectious, misfolded form of a normal protein. These proteins leave destructive amyloid deposits in the brains in which they develop, causing degeneration and eventual death.

They are responsible for Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy, or "mad cow" disease, in cattle.

"The idea of a prion-like mode of progression in dementias, which many scientists are beginning to support, is that the misfolded protein in one neuron will infect a neighbouring brain cell, causing proteins in that cell to misfold in turn, and that the spread of these misfolded proteins flows along certain networks in the brain," explained Weiner.

"For instance, in Alzheimer's, there is a spread of amyloid protein along the memory network. This paper reinforces the idea that the damage occurs progressively along that network and others," he said.

Weiner emphasized that Alzheimer's and frontotemporal dementia "are not infectious diseases" like Creutzfeldt-Jakob. But he said "it may be that a little seed of the disease begins in one neuron in the brain and spreads in a similar way - so it's infectious within the brain, from one neuron to the next."

Their study was published in the March 22 edition of Neuron. (ANI)

Dolphins, cats are not similar despite sharing same genes Jan 30, 5:34 pm
Washington, Jan 30 (ANI): A new research has revealed the reason behind dolphins not being a cat, or the reason of rich diversity in mammals.
Full Story
Porn addicts likelier to exhibit unsafe sexual behaviours Jan 30, 2:01 pm
Washington, Jan 30 (ANI): A new study has reported a link between pornography use and indicators of increased sexual risk such as unsafe sex practices and more sexual partners, with similar findings for Internet pornography and unspecific pornography sources.
Full Story
Babies' 'busy' brains create new knowledge even while sleeping Jan 30, 12:32 pm
Washington, Jan 30 (ANI): It might look like all what babies did was eat, sleep and cry, but in reality their brains are constantly working and creating new knowledge even while they sleep.
Full Story
Men, women more similar when it comes to 'thinking' than previously believed Jan 30, 12:32 pm
Washington, Jan 30 (ANI): Scientists have claimed that men and women are not so different after all, and think quite alike.
Full Story
Comments

LATEST STORIES
TOP VIDEO STORIES
PHOTO GALLERY