Cellular 'glue' may help suppress breast cancer

   Apr 20, 4:44 pm

Washington, Apr 20 (ANI): The protein Perp, associated with desmosomes (the glue that sticks cells together), is involved in suppressing breast cancer and offers a potential new target for future treatment, a new study has revealed.

Desmosomes attach neighbouring cells together and it is these tiny collections of proteins , which are responsible for the mechanical strength of organs and tissues within the body.

Desmosomes are also thought to be involved in helping to suppress cancer. Researchers from Stanford University, UC Berkeley, and UC Davis have discovered that the protein Perp is found associated with desmosomes in breast epithelial cells.

Dr Laura Attardi, who led the research, described how loss of Perp affected normal breast tissue function in mice.

"Perp deficiency caused defects in desmosomal protein expression in breast epithelial cells," Dr Attardi said.

"At the same time there was an enhanced inflammatory response in the breast tissue, and tumours tended to develop more quickly. We also found in the lab that breast cancer cells had abnormally low levels of Perp," she added.

These results showed that Perp is part of the cellular glue that fastens cells together and has a dual role in the prevention of breast cancer. Inflammatory cells promote cancer and lack of cell adhesion is part of the progression of cancer to metastasis. Perp may well be a new indicator for monitoring breast cancer or a future target for molecular treatment.

The study has been published in BioMed Central's open access journal Breast Cancer Research. (ANI)

These Handheld robots can guide you in everyday tasks May 27, 7:33 pm
Washington, May 27 (ANI): A team of researchers have developed a prototype of handheld robots which can understand how best to interact with a tool that "knows and acts".
Full Story
Infants smart enough to first think and then speak May 27, 7:33 pm
Washington, May 27 (ANI): A new research has examined that babies can think before they can speak.
Full Story
DNA changes during drug withdrawal helps addiction treatments May 27, 7:24 pm
Washington, May 27 (ANI): A new study has demonstrated that changes in our DNA during drug withdrawal may offer promising ways of developing more effective treatments for cocaine addiction.
Full Story
Smile to strike up new relationship! May 27, 4:48 pm
Washington, May 27 (ANI): A new research has indicated that smiling at one person can always help to strike up a new relationship.
Full Story
Comments

LATEST STORIES
TOP VIDEO STORIES
PHOTO GALLERY