Doubts cast over theory on how tigers get their stripes

   Apr 30, 3:50 pm

Washington, Apr 30 (ANI): Researchers have challenged a decades-old explanation for how tigers get their stripes.

The research does not nix the theory - called the morphogen theory - but science may now have a hypothetical tiger by the tail as they try to figure out this aspect of how Nature works.

The morphogen theory posits that proteins controlling traits are arranged as gradients, with different amounts of proteins activating genes to create specified physical features.

This theory was first put forth in the 1950s by mathematician and World War II code breaker Alan Turing and refined in the 1960s by Lewis Wolpert. It has been used to explain why a tiger has stripes, among other phenomena.

But some biologists have raised questions about the theory, which contends that physical features are necessarily tied to absolute concentrations of proteins within the morphogen gradient.

If a certain critical mass of protein is present, then a given physical feature-for example, cells that make the skin on your forehead-will appear.

If less than that critical mass is present, a different structure-say, the skin that makes your eyebrows-will appear, and a boundary will be formed between the two structures.

Alternative views have suggested physical features are not necessarily the result of a specified number of proteins, but, rather, come from more complex interactions between multiple gradients that work against one another.

New York University biologists explored this process by studying the fruit fly Drosophila, a powerful model for studying genetic development as it is amenable to precise genetic manipulations.

They focused on one protein, Bicoid (Bcd), which is expressed in a gradient with highest levels at the end of the embryo that will become the mature fly's head.

The researchers, headed by Stephen Small, chair of NYU's biology department, examined a large number of target genes that are directly activated by Bcd.

Each target gene is expressed in a region of the embryo with a boundary that corresponds to a specific structure.

By examining DNA sequences associated with these target genes , the researchers discovered binding sites for three other proteins-Runt, Capicua, and Kruppel-which all act as repressors.

All three proteins are expressed in gradients with highest levels in the middle part of the embryo, and thus are positioned in exactly the opposite orientation compared to the Bcd activation gradient.

By changing the spatial distribution of the repressors and by manipulating their binding sites, Small and his colleagues showed that these repressors antagonize Bcd-dependent activation and are absolutely critical for establishing the correct order of boundaries that are found in a normal embryo.

In other words, contrary to Turing's theory, a single gradient of proteins does not have sufficient power to form the same body plan in each member of a species; however, if there are multiple gradients that work against each other, then the system becomes robust enough for normal development.

While the results raise questions about morphogen theory, the researchers explained that their findings did not "falsify" it, but, rather, suggested it needed some additional refinement.

The study has been reported in the journal Cell. (ANI)

Plant-eating 'King Nose' dinosaurs roamed Utah plains 75m yrs ago Sep 20, 12:28 am
Washington, Sept 20 (ANI): A new research has revealed about the discovery of a hadrosaur species with a truly distinctive nasal profile that lived approximately 75 million years ago during the Late Cretaceous period.
Full Story
New gene associated with 'diabetes' traits found Sep 20, 12:00 am
Washington, Sept 20 (ANI): In a new study, scientists have discovered a gene that is linked to traits involved in diabetes.
Full Story
Stem cells act as 'first aid kits' in repairing damaged immune response Sep 19, 6:30 am
Washington, Sept 19 (ANI): A new study has revealed that stem cell therapy can also work through a mechanism other than cell replacement.
Full Story
'Angelina Jolie effect' helped double breast cancer tests in UK Sep 19, 6:29 am
London, Sept 19 (ANI): A new study has revealed that Angelina Jolie's decision to go public about her double mastectomy has led to a doubling in NHS referrals for genetic tests of breast cancer risk.
Full Story
Comments

LATEST STORIES
TOP VIDEO STORIES
PHOTO GALLERY