2 blood biomarkers improve prediction of heart failure risk

   Nov 11, 11:07 am

Washington, November 11 (ANI): Two researchers including one of Indian origin have developed a simple model that uses age, race, and two blood biomarkers to predict risk of heart failure.

The most widely used models for predicting heart failure rely on a complex combination of lifestyle, demographic, and cardiovascular risk factor information.

But the new model presented by Vijay Nambi, M.D., Ph.D., and Christie Ballantyne, M.D., of The Methodist Hospital Center for Cardiovascular Disease Prevention and the Baylor College of Medicine, uses age, race, and the blood concentrations of two blood biomarkers-troponin T and NT-proBNP-to show whether or not a patient is at elevated risk for heart failure.

They showed that adding these two blood biomarkers to the existing models resulted in the best risk prediction models.

Applying the model to patient data from the ongoing ARIC study (Atherosclerosis Risk in Communities), the researchers found their simple heart failure risk model was comparable to more complex models that take into account age, race, systolic blood pressure, antihypertensive medication use, smoking or former smoking, diabetes, body-mass index, prevalent coronary heart disease and heart rate.

The protein troponin T is part of the troponin complex and is traditionally used in the diagnosis of heart attacks. NT-proBNP is an inactive peptide fragment left over from the production of brain natiuretic peptide (BNP), a small neuropeptide hormone that has been shown to have value in diagnosing recent and ongoing congestive heart failure.

The researchers used both these markers in the prediction of future heart failure (over 10 years) thereby understanding which individuals among a general population are at the highest risk of heart failure.

Their presentation was part of the American Heart Association's Scientific Sessions 2012 in Los Angeles. (ANI)

Groundbreaking study reveals sexual orientation may not be a choice Nov 22, 1:55 pm
London, Nov 22 (ANI): The largest ever study of its kind has found clear links between male sexual orientation and two specific regions of the human genome that erodes the notion that sexual orientation is a choice.
Full Story
Humans settled on Tibetan Plateau 3600 years ago Nov 22, 1:42 pm
Beijing, Nov 22 (ANI): A new study has revealed that humans probably settled on Tibetan Plateau 3600 years ago providing an indication of when humans first settled at high altitudes.
Full Story
First GPS-collar study reveals how leopards co-exist with humans in India Nov 22, 12:07 pm
Washington, Nov 22 (ANI): A new first-of-its-kind GPS-collar study has recently revealed how leopards in India live with people.
Full Story
First complete view of flu virus' key machine revealed Nov 21, 4:14 pm
Washington, Nov 21 (ANI): A new research has come up with the first complete structure of one of the flu virus' key machines i.e. polymerase.
Full Story
Comments

LATEST STORIES
TOP VIDEO STORIES
PHOTO GALLERY