2 blood biomarkers improve prediction of heart failure risk

   Nov 11, 11:07 am

Washington, November 11 (ANI): Two researchers including one of Indian origin have developed a simple model that uses age, race, and two blood biomarkers to predict risk of heart failure.

The most widely used models for predicting heart failure rely on a complex combination of lifestyle, demographic, and cardiovascular risk factor information.

But the new model presented by Vijay Nambi, M.D., Ph.D., and Christie Ballantyne, M.D., of The Methodist Hospital Center for Cardiovascular Disease Prevention and the Baylor College of Medicine, uses age, race, and the blood concentrations of two blood biomarkers-troponin T and NT-proBNP-to show whether or not a patient is at elevated risk for heart failure.

They showed that adding these two blood biomarkers to the existing models resulted in the best risk prediction models.

Applying the model to patient data from the ongoing ARIC study (Atherosclerosis Risk in Communities), the researchers found their simple heart failure risk model was comparable to more complex models that take into account age, race, systolic blood pressure, antihypertensive medication use, smoking or former smoking, diabetes, body-mass index, prevalent coronary heart disease and heart rate.

The protein troponin T is part of the troponin complex and is traditionally used in the diagnosis of heart attacks. NT-proBNP is an inactive peptide fragment left over from the production of brain natiuretic peptide (BNP), a small neuropeptide hormone that has been shown to have value in diagnosing recent and ongoing congestive heart failure.

The researchers used both these markers in the prediction of future heart failure (over 10 years) thereby understanding which individuals among a general population are at the highest risk of heart failure.

Their presentation was part of the American Heart Association's Scientific Sessions 2012 in Los Angeles. (ANI)

Scientists discover 'chink in HIV's armour' Oct 25, 12:41 pm
Washington, Oct 25 (ANI): Scientists have found a new protein, called Ssu72 that seems to be part of a switch used to awaken HIV-1 (the most common type of HIV) from its slumber.
Full Story
Highest altitude human occupation 1 millennia earlier than previously documented Oct 24, 3:59 pm
Washington, Oct 24 (ANI): An archaeological team has found evidence of the highest altitude human occupied land in the southern Peruvian Andes dated 900 years earlier than previously documented.
Full Story
Scientists shed new light on how hormone works in weight loss Oct 24, 2:30 pm
Washington, Oct 24 (ANI): Scientists have found the how the hormone, which is a popular target to develop weight-loss drugs, works in our body.
Full Story
Hunchback 'Horrible Hands' dino had 'incredibly' long arms Oct 24, 1:57 pm
Washington, Oct 24 (ANI): A new study examined the new fossils of an "incredibly" long-armed dinosaur nicknamed "Horrible Hands" and demonstrated that the dinosaur had a prominent hunchback, was omnivorous, and had features that prevented it from sinking into wet ground.
Full Story
Comments

LATEST STORIES
TOP VIDEO STORIES
PHOTO GALLERY