2 blood biomarkers improve prediction of heart failure risk

   Nov 11, 11:07 am

Washington, November 11 (ANI): Two researchers including one of Indian origin have developed a simple model that uses age, race, and two blood biomarkers to predict risk of heart failure.

The most widely used models for predicting heart failure rely on a complex combination of lifestyle, demographic, and cardiovascular risk factor information.

But the new model presented by Vijay Nambi, M.D., Ph.D., and Christie Ballantyne, M.D., of The Methodist Hospital Center for Cardiovascular Disease Prevention and the Baylor College of Medicine, uses age, race, and the blood concentrations of two blood biomarkers-troponin T and NT-proBNP-to show whether or not a patient is at elevated risk for heart failure.

They showed that adding these two blood biomarkers to the existing models resulted in the best risk prediction models.

Applying the model to patient data from the ongoing ARIC study (Atherosclerosis Risk in Communities), the researchers found their simple heart failure risk model was comparable to more complex models that take into account age, race, systolic blood pressure, antihypertensive medication use, smoking or former smoking, diabetes, body-mass index, prevalent coronary heart disease and heart rate.

The protein troponin T is part of the troponin complex and is traditionally used in the diagnosis of heart attacks. NT-proBNP is an inactive peptide fragment left over from the production of brain natiuretic peptide (BNP), a small neuropeptide hormone that has been shown to have value in diagnosing recent and ongoing congestive heart failure.

The researchers used both these markers in the prediction of future heart failure (over 10 years) thereby understanding which individuals among a general population are at the highest risk of heart failure.

Their presentation was part of the American Heart Association's Scientific Sessions 2012 in Los Angeles. (ANI)

Scientists discover deep-sea octopus that broods eggs for over 4 years Jul 31, 12:35 pm
Washington, July 31 (ANI): Scientists have observed a deep-sea octopus that brood its eggs for four and one half years-longer than any other known animal.
Full Story
Future cars may be powered by waste CO2! Jul 31, 11:50 am
Washington, July 31 (ANI): Scientists have synthesized a new catalyst that can convert waste carbon dioxide into fuel and other energy-rich products, which is a big step toward industrialization.
Full Story
Study claims Alps' 53000-yr-old mummified iceman had heart disease genes Jul 31, 11:49 am
Washington, July 31 (ANI): Scientists have revealed that the 5,300-year-old Tyrolean Iceman from the Alps had a strong genetic predisposition for increased risk for coronary heart disease (CHD).
Full Story
Low CO2 levels lead to formation of Antarctic ice sheet Jul 31, 11:24 am
Washington, July 31 (ANI): A new research has demonstrated that massive rearrangements of Earth's continents including decreased CO2 levels caused the abrupt formation of the Antarctic ice sheet.
Full Story
Comments

LATEST STORIES
TOP VIDEO STORIES
PHOTO GALLERY