Scientists find a headway in Antimalarial Drugs .
Washington DC [USA], Oct 27 (ANI): A team of researchers has recently discovered new targets for drug development against life-threatening parasite">malaria parasite, which needs two proteins to infect red blood cells and exit after multiplying .
Researchers from Eunice Kennedy Shriver National Institute in the U .S . sought to uncover the role of plasmepsins IX and X - two of the 10 types of plasmepsin proteins produced by P . falciparum for metabolic and other processes .
The findings indicated that one drug called CWHM-117, which has already been tested in a mouse model of malaria, may help researchers modify CWHM-117 to make it more effective .
The team found plasmepsin IX in rhoptries, specialised cell structures inside the parasite, which help to invade Red Blood Cells .
The parasites lacking plasmepsin IX had defective rhoptries .
The team also discovered that plasmepsin X processes an important protein called SUB1 .
The researchers also identified three experimental malaria drugs that may work by targeting plasmepsin X .
Furthermore, parasites lacking the plasmepsins could potentially be used to screen candidate drugs to identify additional anti-malaria compounds .
The research appears in journal called 'Science' . (ANI)