According to The Hollywood Reporter, the honour will be presented during a gala tribute on June 7 in Los Angeles.
Sir Howard Stringer, chairman of the AFI board of trustees, said, "George Clooney is America's leading man. Director, producer, writer and actor - a modern-day screen icon, who combines the glamour of a time gone by with a ferocious passion for ensuring art's impact echoes beyond the screen."
In 2010, the Academy of Television Arts & Sciences honoured Clooney with the Bob Hope Humanitarian Award in recognition of his humanitarian efforts.
Recent AFI Life Achievement honorees include Diane Keaton, John Williams, Steve Martin, Jane Fonda, Mel Brooks, Shirley MacLaine, Morgan Freeman and Mike Nichols. (ANI)