DNA damage caused by cancer treatment reversed by ZATT protein
ANI | Updated: Oct 09, 2017 10:17 IST
Washington D.C. [U.S.A], Oct. 9 (ANI): In a recent research, a group of scientists have discovered a new way that cells fix an important and dangerous type of DNA damage known as a DNA-protein cross-link (DPC).
According to study's corresponding author Scott Williams, Ph.D., TDP2 was important for removing DPCs, but they did not know how it was directed to where it needed to work, according to corresponding author Scott Williams, Ph.D.
While Matthew Schellenberg, Ph.D., an NIEHS visiting fellow and lead author on the paper, said when DNA becomes tangled inside of cells, organisms use a protein called topoisomerase 2 (TOP2) to untangle it.
Schellenberg noted, "Imagine your DNA is a giant ball of yarn. TOP2 cuts and reties individual threads to disentangle the ball."
Doing so ensures the protein can complete the second part of its job, which is rejoining DNA ends.
Williams shared, "In this study, we discovered a new molecular disarmament apparatus for these cell-killing bombs. ZATT is like a bomb sniffing dog, so when it locates its target, it sounds an alarm to mobilize the recruitment of TDP2, which cuts the red wire to disarm these threats."
Schellenberg shared that chemotherapeutic drugs, such as etoposide are not the only pharmaceuticals that induce DPCs.
He concluded by saying, "We've discovered how we defend against this potent means of cell killing. It is our hope that this information will enable development of new drugs that target these defenses. By lowering the defenses, we may make drugs that kill cancer cells more effective."