The accident took place after a bus and a car rammed into each other on the Bangalore and Chennai national highway near Madhavanagar area of the district.
Reportedly, the bus driver whose attention got diverted, lost control, and rammed into the car travelling in the opposite direction.
The injured are being treated in the Chittoor Government Hospital.
The victims were on their way to Tirupati Tirumala when the mishap occurred. (ANI)