The Virat Kohli-led side will look to extend the series lead to 2-0 and correct the ordinary record in bilateral ODI cricket in South Africa while the hosts will aim to not let their side suffer due to the ruled out injured players.
Neither swashbuckling batsman AB de Villiers nor regular skipper Faf du Plessis will play in the Centurion. Du Plessis has been ruled out for the remaining series and T20Is due to a figure injury, while de Villiers will not be present for two more matches.
Also, the Kohli-led side have not lost a single series in this format in the past two years, which might also serve as motivation for them.
If India win the series, they will also clinch the number one spot in the ICC ODI team rankings.
India: Virat Kohli (c), Shikhar Dhawan, Rohit Sharma, Ajinkya Rahane, Shreyas Iyer, Manish Pandey, Dinesh Karthik, Kedar Jadhav, MS Dhoni (wk), Hardik Pandya, Yuzvendra Chahal, Kuldeep Yadav, Axar Patel, Bhuvneshwar Kumar, Jasprit Bumrah, Mohammed Shami, Shardul Thakur.
South Africa: Aiden Markram (c), Hashim Amla, Quinton de Kock (wk), JP Duminy, Imran Tahir, David Miller, Farhaan Behardien, Heinrich Klaasen, Morne Morkel, Chris Morris, Lungi Ngidi, Andile Phehlukwayo, Kagiso Rabada, Tabraiz Shamsi, Khayelihle Zondo. (ANI)