However, the main focus will be on Raina, as he is returning to the squad after he last played in the shortest format for India in February last year.
The veteran since then has struggled to get back into the side because of both form and fitness issues.
Meanwhile, Jaydev Unadkat will come in for injured Kuldeep Yadav while Bhuvneshwar Kumar will also make a return.
The hosts, on the other hand, will play in the absence of their swashbuckling batsman AB de Villiers as he hurt his knee in the last ODI against India.
South Africa, who will aim for redemption after their ODI debacle, will be lead by JP Duminy in the absence of injured regular skipper Faf du Plessis.
Heinrich Klaasen and Junior Dala will debut for South Africa.
Duminy will forefront a relatively less experienced South African side as veteran Hashim Amla and ODI skipper Aiden Markram have been rested.
The tourists had, earlier, lost the Test series 1-2, but came back strong to thrash South Africa 5-1 in the ODI series.
The T20I series will conclude India's tour of the Rainbow Nation and thus the Men in Blue would look to end it on a high.
The two squads are as follows:
South Africa: JJ Smuts, R Hendricks, JP Duminy (c), D Miller, H Klaasen (wk), F Behardien, C Morris, A Phehlukwayo, D Paterson, Junior Dala, T Shamsi. (ANI)