Earlier, the toss was delayed because of incessant rains which left the outfield wet. The match has been reduced to 42-overs a side.
The game at Old Trafford is set to be Chris Gayle's first ODI since the ICC World Cup 2015, where he made the first double-century in the competition's history, smashing a blistering 215 against Zimbabwe in Canberra.
Windies must win the upcoming series either 5-0 or 4-0 with a tie or no-result if it wants to gain direct entry into the 2019 ICC World Cup in England. A failure to do so would mean that Windies, the 1975 and 1979 world champions, cannot overtake Sri Lanka, currently No. 8 in the ODI rankings.
Only the top seven sides apart from hosts England, currently No. 4, as of September 30 will qualify directly for the 50-over showpiece event in 2019. Teams that do not gain direct entry will get another shot through a qualifying tournament.
England (Playing XI): Alex Hales, Jonny Bairstow, Joe Root, Eoin Morgan(c), Ben Stokes, Jos Buttler(w), Moeen Ali, Chris Woakes, Adil Rashid, Liam Plunkett, David Willey (ANI)