The bus was travelling along a road in Kazakhstan's north-western Aktau region that links the Russian city of Samara to Shymkent, a city in southern Kazakhstan close to the Uzbek border, reported the Independent.
The Kazakh emergencies department said in a statement that only five people managed to escape.
"Five people who managed to escape are receiving medical assistance," the statement said. "The remaining 52 people died on the spot."
The cause of the fire is yet not known. (ANI)