According to Anadolu Agency, the White Helmets civil-defence agency confirmed the death toll and said the attack occurred in the town of Kafr Batna.
Since February 19, escalating hostilities have resulted in 500 deaths and some 1,500 injuries in Eastern Ghouta, with 24 health facilities impacted by shelling and airstrikes, according to UN officials.
Eastern Ghouta, which houses around 400,000 residents, has remained under a crippling regime siege for the last five years with humanitarian access being completely cut off.
In May last year, Russia, Iran and Turkey signed an agreement to set up de-escalation zones, in order to prevent airstrike-related incidents in some parts of Syria.
Syria has been embroiled in a civil war since 2011. Protesters have been long demanding the resignation of President Assad over his autocratic rule. (ANI)