According to the Tolo News, the provincial government media office, in a statement, confirmed the air strike and said it had killed at least four militants and that eight others were injured.
The airstrike was carried out in the vicinity of the restive Khogyani district on Thursday.
United States' unmanned aerial vehicles targetted a compound of the terror group in the Wazir Tangi area.
No group has commented on the airstrike so far.
Earlier this week, at least seven IS militants were killed in a drone strike. (ANI)